DDX58 Antibody
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中文名稱：DDX58兔多克隆抗體
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貨號：CSB-PA006638GA01HU
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規格：￥3,900
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其他：
產品詳情
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Uniprot No.：
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基因名：
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別名：Ddx58 antibody; DDX58_HUMAN antibody; DEAD (Asp Glu Ala Asp) box polypeptide 58 antibody; DEAD (Asp Glu Ala Asp/His) box polypeptide antibody; DEAD box protein 58 antibody; DEAD/H (Asp Glu Ala Asp/His) box polypeptide RIG1 antibody; DKFZp434J1111 antibody; DKFZp686N19181 antibody; FLJ13599 antibody; Probable ATP dependent RNA helicase DDX58 antibody; Probable ATP-dependent RNA helicase DDX58 antibody; Retinoic acid inducible gene 1 protein antibody; Retinoic acid-inducible gene 1 protein antibody; Retinoic acid-inducible gene I protein antibody; RIG I antibody; Rig-1 antibody; RIG-I antibody; RIG1 antibody; rigi antibody; RLR 1 antibody; RNA helicase antibody; RNA helicase RIG I antibody; SGMRT2 antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Human DDX58
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免疫原種屬：Homo sapiens (Human)
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抗體亞型：IgG
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純化方式：Antigen Affinity purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
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產品提供形式：Liquid
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應用范圍：ELISA,WB,IF
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Innate immune receptor that senses cytoplasmic viral nucleic acids and activates a downstream signaling cascade leading to the production of type I interferons and proinflammatory cytokines. Forms a ribonucleoprotein complex with viral RNAs on which it homooligomerizes to form filaments. The homooligomerization allows the recruitment of RNF135 an E3 ubiquitin-protein ligase that activates and amplifies the RIG-I-mediated antiviral signaling in an RNA length-dependent manner through ubiquitination-dependent and -independent mechanisms. Upon activation, associates with mitochondria antiviral signaling protein (MAVS/IPS1) that activates the IKK-related kinases TBK1 and IKBKE which in turn phosphorylate the interferon regulatory factors IRF3 and IRF7, activating transcription of antiviral immunological genes including the IFN-alpha and IFN-beta interferons. Ligands include 5'-triphosphorylated ssRNAs and dsRNAs but also short dsRNAs (<1 kb in length). In addition to the 5'-triphosphate moiety, blunt-end base pairing at the 5'-end of the RNA is very essential. Overhangs at the non-triphosphorylated end of the dsRNA RNA have no major impact on its activity. A 3'overhang at the 5'triphosphate end decreases and any 5'overhang at the 5' triphosphate end abolishes its activity. Detects both positive and negative strand RNA viruses including members of the families Paramyxoviridae: Human respiratory syncytial virus and measles virus (MeV), Rhabdoviridae: vesicular stomatitis virus (VSV), Orthomyxoviridae: influenza A and B virus, Flaviviridae: Japanese encephalitis virus (JEV), hepatitis C virus (HCV), dengue virus (DENV) and west Nile virus (WNV). It also detects rotaviruses and reoviruses. Detects and binds to SARS-CoV-2 RNAs which is inhibited by m6A RNA modifications (Ref.63). Also involved in antiviral signaling in response to viruses containing a dsDNA genome such as Epstein-Barr virus (EBV). Detects dsRNA produced from non-self dsDNA by RNA polymerase III, such as Epstein-Barr virus-encoded RNAs (EBERs). May play important roles in granulocyte production and differentiation, bacterial phagocytosis and in the regulation of cell migration.
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基因功能參考文獻：
- These results refine the RNA sensing paradigm for nuclear-replicating viruses and reveal a previously unrecognized subcellular milieu for RIG-I-like receptor sensing. PMID: 30097581
- fascin1 constitutively interacts with IkappaB kinase (IKK) in the RIG-I signaling pathway. In summary, we have identified fascin1 as a suppressor of the RIG-I signaling pathway associating with IkappaB kinase in DLD-1 colon cancer cells to suppress immune responses to viral infection. PMID: 29496994
- The structure of RIG-I C268F in complex with double-stranded RNA reveals that C268F helps induce a structural conformation in RIG-I that is similar to that induced by ATP PMID: 30047865
- FBXW7 is critical for RIG-I stabilization during antiviral responses. PMID: 28287082
- These findings imply a novel function for DDX6 as an RNA co-sensor and signaling enhancer for RIG-I. PMID: 29949917
- Identification of a second binding site on the RIG-I TRIM25 B30.2 domain has been reported. PMID: 29259080
- Aging thus compromises both the primary and secondary RIG-I signaling pathways that govern expression of type I IFN genes, thereby impairing antiviral resistance to IAV. PMID: 29233916
- RIG-I-like receptors have a role in induction of interferon-beta1 in antiviral gene expression PMID: 29098213
- MCCC1 plays an essential role in virus-triggered, MAVS-mediated activation of NF-kappaB signaling. PMID: 27629939
- The authors find that KHSRP associates with the regulatory domain of RIG-I to maintain the receptor in an inactive state and attenuate its sensing of viral RNA (vRNA). PMID: 28248290
- In this study, the authors determined that, in contrast to the RIG-I CARD domain, full-length RIG-I must undergo K63-linked ubiquitination at multiple sites to reach full activity. PMID: 27387525
- RIG-1 overexpression is protective for cigarette smoke exposure enhanced susceptibility to influenza infection. PMID: 28865477
- These results showed that the knockdown of RIGI reduced the inhibition of cell proliferation, cell cycle arrest and apoptosis in the alltrans retinoic acid induced NB4 acute promyelocytic leukemia cells via the AKTFOXO3A signaling pathway. PMID: 28656276
- The host RIG-I signaling pathway is a key early obstacle to paramyxovirus infection, as it results in rapid induction of an antiviral response. This study shows that paramyxovirus V proteins interact with and inhibit the activation of RIG-I, thereby interrupting the antiviral signaling pathway and facilitating virus replication. PMID: 29321315
- These findings indicated that hepatitis B virus-induced miR146a attenuates cell-intrinsic anti-viral innate immunity through targeting RIG-I and RIG-G. PMID: 27210312
- Taken together, these findings reveal an essential role of CypA in boosting RIG-I-mediated antiviral immune responses by controlling the ubiquitination of RIG-I and MAVS. PMID: 28594325
- RIG-I-like receptors (RLRs) are well-known viral RNA sensors in the cytoplasm that recognize the nonself signatures of viral RNAs to trigger IFN responses. PMID: 28475461
- Knockdown of PBRM1 in colon cancer cells increased the expression of two receptor genes (RIG-I and MDA5) and upregulated interferon (IFN)-related and inflammation-related gene signatures. PMID: 28940253
- Dengue virus infection of human dendritic cells drives follicular T helper cells formation via crosstalk of RIG-I and MDA5. PMID: 29186193
- DDX58_rs10813831 T-allele may be associated with a reduced risk of nodular sclerosis EBV-related cHL, which suggests a role for RIG-I (retinoic acid-inducible gene I), encoded by DDX58, in these cases. PMID: 27267403
- mutations in the genes encoding for RIG-I and MDA5 have been identified to cause rare diseases including Aicardi-Goutieres syndrome, Systemic Lupus Erythematosus in certain individuals as well as classic and atypical Singleton-Merten syndrome. Patients carrying mono-allelic mutations in MDA5 and RIG-I show constitutive activation of the RIG-I receptors and downstream signalling PMID: 26993858
- These findings demonstrate how IFNgamma induced CK2 regulates RIG-I to drive a complex program of metabolic adaptation and redox homeostasis, crucial for determining glioma cell fate. PMID: 26631910
- Data show that host-derived RNAs, most prominently 5S ribosomal RNA pseudogene 141 (RNA5SP141), bound to RIG-I during infection with herpes simplex virus 1 (HSV-1). PMID: 29180807
- RIG-I expression is markedly increased in the affected skin derived from psoriasis patients and from both IL-23- and imiquimod -induced psoriasis-like mouse model. PMID: 28377495
- DDX58 was confirmed to be the downstream target of TRIM24, whose downregulation is essential for the migratory phenotype induced by GLUT4-TRIM24 activation in head and neck squamous cell carcinoma cells. PMID: 28061796
- TRIM25 actively participates in higher-order assembly of the RIG-I signalosome. PMID: 27425606
- This study evaluation the roles of SOCS1, the regulator of TLR9, RIG-I, and CD152 in patients with liver fibrosis/cirrhosis; the use of polymorphisms as markers for genetic risk is reported. PMID: 28762092
- study documents that recombinant measles virus produce defective interfering genomes that have high immunostimulatory properties via their binding to RIG-I and LGP2 proteins, both of which are cytosolic nonself RNA sensors of innate immunity. PMID: 28768856
- findings define the WHIP-TRIM14-PPP6C mitochondrial signalosome required for RIG-I-mediated innate antiviral immunity. PMID: 29053956
- both IL-6 and RIG-I are downstream molecules of STING along the DNA sensor pathway. PMID: 28806404
- These data suggest that prior exposure to IFN-gamma may leave an epigenetic mark on the chromatin that enhances airway cells' ability to resist infection, possibly via epigenetic upregulation of RIG-I. PMID: 28481620
- findings show that RIG-I and MDA5 triggering by dengue virus leads to TH1 polarization, which is characterized by high levels of IFN-gamma; identified RIG-I and MDA5 as critical players in innate and adaptive immune responses against Dengue virus PMID: 28507028
- Results identified a negative-feedback mechanism that targets RIG-I activity mediated by DAPK1. RIG-I-mediated antiviral signaling activates DAPK1 kinase activity and DAPK1 inactivates RIG-I RNA sensing by direct phosphorylation of RIG-I. PMID: 28132841
- Mechanistically, West Nile virus NS1 targets RIG-I and melanoma differentiation-associated gene 5 (MDA5) by interacting with them and subsequently causing their degradation by the proteasome. PMID: 28659477
- RIG-I stimulates the cellular innate immunity against hepatitis E virus infections. PMID: 28195391
- dynamic sumoylation and desumoylation of MDA5 and RIG-I modulate efficient innate immunity to RNA virus and its timely termination. PMID: 28250012
- Taken together, the present study reveals that T80 phosphorylation of influenza A virus NS1 reduced virus replication through controlling RIG-I-mediated interferon production and viral ribonucleoprotein activity. PMID: 27376632
- results suggest that RNAs containing modified nucleotides interrupt signaling at early steps of the RIG-I-like innate immune activation pathway PMID: 27651356
- The authors found that in Sendai virus C protein deletion mutant-infected cells, Sendai virus defective interfering RNA also functioned as an exclusive RIG-I ligand. PMID: 28631605
- ArfGAP domain-containing protein 2 (ADAP2) is identified as a key novel scaffolding protein that integrates different modules of the RIG-I pathway, located at distinct subcellular locations, and mediates cellular antiviral type I interferon production. PMID: 27956705
- the bending structure of the panhandle RNA negates the requirement of a 5'-PPP moiety for RIG-I activation. PMID: 27288441
- RIG-I-like receptor-induced IRF3 mediated pathway of apoptosis (RIPA): a new antiviral pathway PMID: 27815826
- The severe acute respiratory syndrome coronavirus N protein was found to bind to the SPRY domain of the tripartite motif protein 25 (TRIM25) E3 ubiquitin ligase, thereby interfering with the association between TRIM25 and retinoic acid-inducible gene I (RIG-I) and inhibiting TRIM25-mediated RIG-I ubiquitination and activation. PMID: 28148787
- The regulation of STING via RIG-I-mediated innate immune sensing. PMID: 27512060
- These results suggest that inhibition of RIG-I-mediated type I interferon responses by Enterovirus 71 may contribute to the pathogenesis of viral infection. PMID: 27633794
- Modulates RIG-I-dependent antiviral response is through post-translational modifications of or protein-protein interactions with RIG-I. [review] PMID: 27572506
- Pyruvate carboxylase activates the RIG-I-like receptor-mediated antiviral immune response by targeting the MAVS signalosome. PMID: 26906558
- This study shows that RIG-I activation results in MKP-1-mediated inhibition of cell proliferation in melanoma cells via controlling the p38-HSP27, c-Jun and rpS6 pathways PMID: 26829212
- HepaRG cells express a similar pattern of functional TLR/RLR as compared to PHH, thus qualifying HepaRG cells as a surrogate model to study pathogen interactions within a hepatocyte innate system. PMID: 26144659
- COPD patients had higher interleukin (IL)-1 and IL-8 mRNA expression levels, and these inflammatory cytokines positively correlate with MDA-5 levels. However, there was no difference in the expression of RIG-I between COPD patients and control subjects. PMID: 24992168
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相關疾病：Singleton-Merten syndrome 2 (SGMRT2)
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亞細胞定位：Cytoplasm. Cell projection, ruffle membrane. Cytoplasm, cytoskeleton. Cell junction, tight junction. Note=Colocalized with TRIM25 at cytoplasmic perinuclear bodies. Associated with the actin cytoskeleton at membrane ruffles.
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蛋白家族：Helicase family, RLR subfamily
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組織特異性：Present in vascular smooth cells (at protein level).
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數據庫鏈接：
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