DDT Antibody
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中文名稱：DDT兔多克隆抗體
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貨號：CSB-PA221047
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規(guī)格：￥1090
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圖片：
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Immunohistochemical analysis of paraffin-embedded human-placenta, antibody was diluted at 1:200 -
Immunohistochemical analysis of paraffin-embedded human-placenta, antibody was diluted at 1:200
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其他：
產(chǎn)品詳情
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Uniprot No.：
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基因名：DDT
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別名：D dopachrome decarboxylase antibody; D dopachrome tautomerase antibody; D-dopachrome decarboxylase antibody; D-dopachrome tautomerase antibody; DDCT antibody; Ddt antibody; DOPD_HUMAN antibody; Phenylpyruvate tautomerase II antibody
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宿主：Rabbit
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反應(yīng)種屬：Human,Mouse,Rat
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免疫原：Synthetic peptide from Human protein at AA range: 50-90
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免疫原種屬：Homo sapiens (Human)
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標(biāo)記方式：Non-conjugated
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純化方式：The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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產(chǎn)品提供形式：Liquid
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應(yīng)用范圍：IHC,ELISA
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推薦稀釋比：
Application Recommended Dilution IHC IHC-p:1:50-300 ELISA 1:10000-20000 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產(chǎn)品評價
相關(guān)產(chǎn)品
靶點詳情
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功能：Tautomerization of D-dopachrome with decarboxylation to give 5,6-dihydroxyindole (DHI).
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基因功能參考文獻(xiàn)：
- D-dopachrome tautomerase transcription may be regulated in a cell-dependent manner, and was enhanced by AMPK activation in SGBS adipocytes through inhibiting the mTOR signaling PMID: 28445821
- The knockdown of D-DT and MIF, individually and additively, inhibited the proliferation, migration, and invasion in HeLa and SiHa cells and restrained the growth of xenograft tumor. PMID: 28338494
- These results have implications for the manner in which D-DT and MIF compete with each other for binding to the CD74 receptor and for the relative potency of DRa1-MOG-35-55 and RTL1000 for competitive inhibition of D-DT and MIF binding and activation through CD74. PMID: 27573366
- Study demonstrated that DDT was over- expressed in pancreatic ductal adenocarcinoma (PDAC) tissues and cell lines in a pattern correlated with MIF, and knockdown of DDT and MIF in PANC- 1 cells cooperatively inhibited cell proliferation, invasion and tumor formation. The tautomerase activities of both MIF and DDT are required for their negative regulatory role in p53 and their tumor-promoting functions. PMID: 27434219
- DDT was increased in burn patients. PMID: 27209369
- Gene expression level of DDT is significantly higher in AD patients when compared to normal controls. PMID: 26943237
- High MIF-2 levels are predictive of the development of organ dysfunction in myocardial ischemia reperfusion injury. PMID: 26234719
- Both p53 wildtype and mutant human lung adenocarcinoma tumors rely on MIF family members for maximal cell growth and survival. PMID: 24932684
- findings identify DDT as a functionally redundant but more potent cytokine to MIF in cancer and suggest that current attempts to inhibit MIF signaling may fail because of DDT compensation. PMID: 24356968
- D-dopachrome tautomerase secreted from adipocytes acts on preadipocytes to promote IL-6 expression and to inhibit adipogenesis by suppressing the induction of genes encoding adipogenic regulators PMID: 22951300
- DDT acts on adipocytes to regulate lipid metabolism through AMPK and/or PKA pathway(s) and improves glucose intolerance caused by obesity. PMID: 22428043
- These data indicate that D-DT is a MIF-like cytokine. PMID: 21817065
- D-DT-dependent beta-catenin stabilization is regulated by COX-2 expression, suggesting the existence of an amplification loop between COX-2- and beta-catenin-mediated transcription in these cells PMID: 21071513
- role of tautomerase active site of macrophage migration inhibitory factor as a potential target for discovery of novel anti-inflammatory agents PMID: 11997397
- DDT is for the first time demonstrated in the skin and can be related to inflammation, and its covariation with MIF strengthens this observation. PMID: 12823441
- D-dopachrome tautomerase (D-DT) and macrophage migration inhibitory factor, individually and additively, promote vascular endothelial growth factor and CXCL8 expression in human lung adenocarcinoma cell lines. PMID: 18684922
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亞細(xì)胞定位：Cytoplasm.
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蛋白家族：MIF family
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數(shù)據(jù)庫鏈接：
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