DCT Antibody
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中文名稱：DCT兔多克隆抗體
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貨號：CSB-PA282142
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規格：￥1090
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圖片：
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Western blot analysis of HELA A549 Cell Lysate, antibody was diluted at 1:1000. Secondary antibody was diluted at 1:20000
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其他：
產品詳情
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Uniprot No.：
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基因名：
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別名：L dopachrome tautomerase antibody; DCT antibody; Dopachrome delta isomerase antibody; Dopachrome tautomerase antibody; Dopachrome tautomerase dopachrome delta isomerase; tyrosine related protein 2 antibody; DT antibody; EC 5.3.3.12 antibody; L dopachrome Delta isomerase antibody; L-dopachrome Delta-isomerase antibody; L-dopachrome tautomerase antibody; TRP 2 antibody; TRP-2 antibody; TRP2 antibody; Tyrosinase related protein 2 antibody; Tyrosinase-related protein 2 antibody; TYRP2 antibody; TYRP2_HUMAN antibody
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宿主：Rabbit
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反應種屬：Human,Mouse
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免疫原：Synthetic peptide from Human protein at AA range: 1268-1341
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
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純化方式：The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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產品提供形式：Liquid
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應用范圍：WB,ELISA
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推薦稀釋比：
Application Recommended Dilution WB 1:500-1:2000 ELISA 1:5000-1:20000 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
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靶點詳情
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功能：Catalyzes the conversion of L-dopachrome into 5,6-dihydroxyindole-2-carboxylic acid (DHICA).
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基因功能參考文獻：
- High DCT expression is associated with progressive multiple sclerosis. PMID: 28923927
- High DCT expression is associated with HPV16 Infection. PMID: 28095444
- Data indicate that the caveolin-1 (CAV1) control on dopachrome tautomerase (DCT) gene expression, DCT post-translational processing, and subcellular distribution is cell phenotype-dependent. PMID: 27053106
- The effect of DCT on UVR DNA damage responses and survival pathways in melanocytes was examined by knockdown experiments using melanoma cells, neonatal melanoblasts in monoculture and in co-culture with keratinocytes. PMID: 25346513
- Report dopachrome tautomerase expression in mealanocytic tumors. PMID: 24709887
- The results suggested that the miRNAs may be involved in MITF regulation of TYR, TYRP1 and TYRP2, which provides a new clue for understanding the role of miRNAs in melanocyte dysfunctional disease. PMID: 22898827
- Data suggest that macrophage migration inhibitory factor (MIF) and d-dopachrome tautomerase (d-DT) act cooperatively to inhibit steady-state phosphorylation and activation of AMPK in LKB1 wild type and LKB1 mutant non-small cell lung carcinomas cells. PMID: 22988252
- human TRP2 counteracts apoptotic cell death induction, possibly by means of its L-dopachrome tautomerase activity, and negatively affects the p53 pathway PMID: 20520707
- Trp2 SNP2 allele is a risk factor for the development and severity of degenerative disc disease in a Chinese Han population. PMID: 20356546
- Data suggest that OTX2 may regulate retinal pigment epithelium (RPE)-specific target genes, such as DOPAchrome tautomerase (DCT), thereby maintaining the homeostasis of RPE. PMID: 12559959
- Because TRP-2(181-190) overlaps with the known HLA-A*0201-presented epitope TRP-2(180-188), an 11mer peptide encompassing both epitopes might be of specific value for vaccination of a broad population of melanoma patients. PMID: 15856458
- Transgenic Dct regulates neural progenitor cell proliferation in a mouse model. PMID: 16857183
- No genetic susceptibility or increased risk attributed to the tyrosinase gene family in Vogt-Koyanagi-Harada disease in Japanese. PMID: 17200659
- Anemonin, an active compound of C. crassifolia, inhibits melanin synthesis by inhibiting the transcription of the genes encoding TYR, TRP1, and TRP2. PMID: 17766092
- we studied a possible role of dopachrome tautomerase in the oxidative stress response in the amelanotic WM35 melanoma cell line. PMID: 18206123
- We observe strong evidence for positive selection for DCT in Asians PMID: 18312627
- Tyrosinase-, gp100-, or TRP-2-specific CD8(+) T cells could not be identified in the peripheral blood of individuals with vitiligo [TRP-2]. PMID: 18337837
- TRP-2 acts on quinone metabolites other than DOPAchrome, e.g., in the catecholamine pathway, and limits their deleterious effects. PMID: 18674612
- tyrosinase-related protein 2 (TRP-2) transcript is not detected in the peripheral blood mononuclear cells (PBMC) of vitiligo patients PMID: 19284502
- Expression profiling demonstrated that the DCT-expressing cell population expressed adrenergic and muscarinic receptors and displayed transcriptional profiles distinct from dermal melanocytes PMID: 19855129
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亞細胞定位：Melanosome membrane; Single-pass type I membrane protein. Melanosome.
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蛋白家族：Tyrosinase family
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