DCP1A Antibody
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中文名稱：DCP1A兔多克隆抗體
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貨號：CSB-PA885684ESR1HU
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規格：￥440
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圖片：
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Western blot
All lanes: DCP1A antibody at 3.79μg/ml
Lane 1: Jurkat whole cell lysate
Lane 2: HepG2 whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 64, 60 kDa
Observed band size: 64, 40 kDa -
Immunohistochemistry of paraffin-embedded human lung tissue using CSB-PA885684ESR1HU at dilution of 1:100 -
Immunohistochemistry of paraffin-embedded human placenta tissue using CSB-PA885684ESR1HU at dilution of 1:100
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) DCP1A Polyclonal antibody
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Uniprot No.：
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基因名：DCP1A
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別名：DCP1 decapping enzyme homolog A antibody; Dcp1a antibody; DCP1A_HUMAN antibody; Decapping enzyme hDcp1a antibody; Decapping mRNA 1A antibody; HSA275986 antibody; mRNA decapping enzyme 1A antibody; mRNA-decapping enzyme 1A antibody; Nbla00360 antibody; Putative protein product of Nbla00360 antibody; Smad4 interacting transcriptional co activator antibody; Smad4-interacting transcriptional co-activator antibody; Smad4-interacting transcriptional co-activator antibody; SMAD4IP1 antibody; SMIF antibody; Transcription factor SMIF antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Recombinant Human mRNA-decapping enzyme 1A protein (303-582AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：Antigen Affinity Purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
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產品提供形式：Liquid
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應用范圍：ELISA, WB, IHC
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推薦稀釋比：
Application Recommended Dilution WB 1:1000-1:5000 IHC 1:20-1:200 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP. Contributes to the transactivation of target genes after stimulation by TGFB1. Essential for embryonic development.
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基因功能參考文獻：
- Overexpression of DCP1A is associated with malignant melanoma. PMID: 29076924
- The results suggest that overexpressed Dcp1a and GW182 can form different cytoplasmic aggregates and play distinct biological roles in the miRNA pathway. PMID: 28488892
- The E3 ligase TRAF6 binds to DCP1a and indirectly regulates DCP1a phosphorylation, expression of decapping factors, and gene-specific mRNA decay. PMID: 27315556
- DCP1A rs11551405 may have a prognostic effect on survival of CM patients. PMID: 27578485
- The assembly of EDC4 and Dcp1a into processing bodies is critical for the translational regulation of IL-6. PMID: 25970328
- Phosphorylation at serine 315, serine 319, and threonine 321 of DCP1A modulates IL-8 expression during respiratory syncytial virus infection. PMID: 25796077
- The data indicates that DCP2 activation by DCP1 occurs preferentially on the EDC4 scaffold, which may serve to couple DCP2 activation by DCP1 with 5'-to-3' mRNA degradation by XRN1 in human cells. PMID: 24510189
- Malin regulates the recruitment of mRNA-decapping enzyme 1A (Dcp1a) to processing bodies. PMID: 23131811
- hDcp1a has a role in control of processing body dynamics during the cell cycle via phosphorylation PMID: 23300942
- Reveal DCP1a as a multifunctional regulator of mRNA expression and suggest a role for JNK kinase phosphorylation in controlling the subcellular localization of DCP1a in response to stress or inflammatory stimuli. PMID: 21859862
- Data show the presence of P-body-like foci in mouse oocytes, as revealed by the presence of Dcp1a and the colocalization of RNA-associated protein 55 (RAP55) and the DEAD box RNA helicase Rck/p54. PMID: 19812249
- Overexpression of wild-type SMIF enhanced expression of TGFbeta/BMP regulated genes, whereas a dominant-negative SMIF mutant suppressed expression. PMID: 11836524
- These data suggest that a human decapping complex containing decapping enzymes hDcp1a and hDcp2 may be recruited to mRNAs containing premature termination codons by the hUpf proteins. PMID: 12417715
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亞細胞定位：Cytoplasm, P-body. Nucleus.
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蛋白家族：DCP1 family
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組織特異性：Detected in heart, brain, placenta, lung, skeletal muscle, liver, kidney and pancreas.
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數據庫鏈接：
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