DCC Antibody

說明書

中文名稱：

DCC兔多克隆抗體
貨號：

CSB-PA827634
規格：

￥1100
圖片：
The image on the left is immunohistochemistry of paraffin-embedded Human gastic cancer tissue using CSB-PA827634(DCC Antibody) at dilution 1/70, on the right is treated with synthetic peptide. (Original magnification: ×200)

The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA827634(DCC Antibody) at dilution 1/70, on the right is treated with synthetic peptide. (Original magnification: ×200)
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

Uniprot No.：

P43146
基因名：

DCC
別名：

Colorectal cancer related chromosome sequence 18 antibody; Colorectal cancer suppressor antibody; CRC 18 antibody; CRC18 antibody; CRCR 1 antibody; CRCR1 antibody; DCC antibody; DCC_HUMAN antibody; Deleted in colorectal cancer protein antibody; Deleted in colorectal carcinoma antibody; Immunoglobulin superfamily DCC subclass member 1 antibody; Netrin receptor DCC antibody; Tumor suppressor protein DCC antibody
宿主：

Rabbit
反應種屬：

Human,Mouse,Rat
免疫原：

Synthetic peptide of Human DCC
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

Antigen affinity purification
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
產品提供形式：

Liquid
應用范圍：

ELISA,IHC

推薦稀釋比：

Application	Recommended Dilution
ELISA	1:2000-1:5000
IHC	1:50-1:200

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor gene.
基因功能參考文獻：
1. Based on the variable expressivity and incomplete penetrance present in heterozygous carriers of a DCC variant, classification and clinical interpretation of missense variants is challenging in the absence of evidence of pathogenicity originated from functional studies PMID: 29366874
2. Study results indicate that DCC controls corticospinal tract midline crossing in both humans and mice, and that this process is non cell-autonomous in mice. PMID: 28341853
3. rs2229080 and rs7504990 polymorphisms in DCC might be related with breast cancer susceptibility in Chinese women. PMID: 27127179
4. Somatic DCC mutations are associated with metastatic NUT midline carcinoma. PMID: 28967088
5. Authors demonstrate that tripartite motif protein 9 (TRIM9)-dependent ubiquitination of DCC blocks the interaction with and phosphorylation of FAK. PMID: 28701345
6. Environmental and endogenous proteases may contribute to cancer development by depleting DCC and neogenin. PMID: 27716118
7. Identified DCC mutations in four families. PMID: 28250454
8. DCC polymorphism maybe responsible for successful treatment of patients with hydrochlorothiazide . diagnosed with hypertension. PMID: 27381900
9. Deleted in colorectal cancer (DCC) confers susceptibility to depression-like behaviors in humans and mice and Is regulated by miR-218. By regulating DCC, miR-218 may be a switch of susceptibility versus resilience to stress-related disorders. PMID: 27773352
10. DCC/18q and ERBB2/17q gene copy number variations are associated with disease-free survival in microsatellite stable colon cancer PMID: 28006840
11. Allelic and genotypic frequencies of the DCC polymorphism rs2229080 were nominally associated with schizophrenia. PMID: 27055860
12. Results of APC and DCC LOH, KRAS and microsatellite instability indicate our colorectal cancer cases were typical of sporadic cancers following the 'chromosomal instability' pathway. PMID: 26970738
13. The study identified DCC as a differentially expressed gene and clustered meningiomas into DCC low expression (3 grade I and 3 grade II tumors), DCC medium expression (2 grade I and 1 grade II tumors), and DCC high expression (5 grade I tumors) groups. PMID: 27096627
14. Data suggest that, in response to netrin-1/netrin receptor (DCC) signaling, p120RasGAP is recruited to growth cones and supports axon outgrowth; p120RasGAP Src homology 2 domains exhibit scaffolding properties sufficient to support axon outgrowth. PMID: 26710849
15. By analyzing multiple myeloma-derived cell lines and patient-derived primary CD138-positive plasma cells ... authors show for the first time that transcriptional dysregulation of DCC is involved in the progression of plasma cell malignancy. PMID: 26390996
16. the transfected DCC gene can suppress cell proliferation and lead to downregulation of CEA expression in SW1116 cells. PMID: 26345965
17. Signaling mechanism of the netrin-1 receptor DCC in axon guidance PMID: 25881791
18. NTN1-DCC pathway contains targets of FDA-approved drugs and may offer promise for guiding applied clinical research on preventive and therapeutic interventions for AMD PMID: 25950802
19. DCC mutation correlated with fractionated mirroring in individuals with Congenital mirror movements PMID: 25813273
20. Data show that silencing ezrin-radixin-moesin (ERM) protein expression ablates deleted in colorectal carcinoma protein (DCC)-protein kinase A (PKA) interaction and specifically blocks netrin-induced PKA activity and phosphorylation. PMID: 25575591
21. Three novel truncating mutations of DCC are associated with congenital mirror movements. PMID: 24808016
22. EDNRB and/or DCC methylation in salivary rinses compares well to examination by an expert clinician in CRC of oral lesions. PMID: 23637120
23. genetic variations in DCC rs714 (A>G) modulate risk of esophageal and gastric cancers in a high-risk Kashmir population. PMID: 23765761
24. Ethnic Malays is genetically susceptible to H. pylori infection and is possibly mediated through a genetic variation in the DCC gene. PMID: 22829558
25. results suggested that cohypermethylation of p14 in combination with DCC and/or CADM1 may be an independent prognostic factor for recurrence in patients with stage I ESCC PMID: 23310950
26. Netrin-1 and DCC are increased in diseased lumbar intervertebral discs and may play a role in the process of neurovascular growth. PMID: 22588384
27. This study re-affirms the role of plausible tumor suppressor DCC variants, in gallbladder carcinogenesis and the risk haplotype may be explored as a useful marker for gallbladder cancer susceptibility. PMID: 23353777
28. The results of this study suggested that DCC as a promising novel candidate gene that may contribute to the genetic basis behind individual differences in susceptibility to schizophrenia. PMID: 22418395
29. SNP rs7504990 in the DCC showed genome-wide significant association with gallbladder cancer susceptibility. PMID: 22318345
30. An unexpected binding mode of the DCC peptide to the subdomain C groove of the FERM domain, which is distinct from previously reported beta-beta associations found in radixin-adhesion molecule complexes. PMID: 21642953
31. Lost expression of DCC gene is associated with ovarian cancer. PMID: 20054719
32. study reports a novel DCC gene mutation responsible for congenital isolated persistent mirror movements in an Italian family and provide evidence that this entity is genetically heterogeneous PMID: 21242494
33. our findings might indicate also an important role for DCC and netrin-1 in human foetal central nervous system development PMID: 20609112
34. study found that individuals affected with congenital mirror movements carried protein-truncating mutations in DCC; mutant DCC protein revealed a defect in netrin-1 binding; DCC has an important role in lateralization of the nervous system PMID: 20431009
35. DCC methylation was observed in the course of gastric carcinogenesis and disappeared in advanced gastric carcinoma. PMID: 20150623
36. DCC receptor is localized to syncytiotrophoblasts and invasive extravillous cytotrophoblasts during the first trimester and at term. PMID: 19826074
37. Altered expression of DCC protein is detectable in gastric carcinomas, an event that may have a role in the development of the disease. PMID: 11518545
38. The netrin-1 receptor DCC promotes filopodia formation and cell spreading by activating Cdc42 and Rac1. PMID: 11817894
39. Loss of dcc gene expression is associated with acute myelogenous leukemia PMID: 12060632
40. loss of DCC expression occurs in some colon adenomas, but is insufficient to drive the adenoma to carcinoma progression. PMID: 12432238
41. data suggest that the codon 201 polymorphism of the DCC gene was a target of LOH, and predicted prognosis in colorectal cancer patients PMID: 12787729
42. DCC binds to netrin, which regulates its interactions with heparin PMID: 12810718
43. Prognostic significance of the DCC gene protein expression in high-risk resected gastric carcinoma PMID: 12901278
44. Deletions in this gene are found in colorectal and gastric cancers PMID: 12901294
45. Multiple aberrations involving the DCC locus may play a role in the progression of nephroblastomas, and hence confer a poorer prognosis. PMID: 14631365
46. DCC/netrin-1 signaling may commit cells to the transition of endometrial gland architecture or function from a proliferating to a secretory phase. PMID: 15491747
47. Binding of netrin-1 to its receptors inhibits tumour suppressor p53-dependent apoptosis (review) PMID: 15573119
48. DCC binds netrin through the fourth fibronectin type III domain. PMID: 15574733
49. DCC expression appears not to be predictive in poor survival outcome in patients with stage II or III colorectal cancer. PMID: 15722793
50. DCC in both commissural neurons and immortalized cells, is partially associated with cholesterol- and sphingolipid-enriched membrane domains named lipid rafts. PMID: 15811950
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相關疾病：

Mirror movements 1 (MRMV1); Gaze palsy, familial horizontal, with progressive scoliosis, 2 (HGPPS2)
亞細胞定位：

Membrane; Single-pass type I membrane protein.
蛋白家族：

Immunoglobulin superfamily, DCC family
組織特異性：

Found in axons of the central and peripheral nervous system and in differentiated cell types of the intestine. Not expressed in colorectal tumor cells that lost their capacity to differentiate into mucus producing cells.
數據庫鏈接：

HGNC: 2701

OMIM: 120470

KEGG: hsa:1630

STRING: 9606.ENSP00000389140

UniGene: Hs.162025

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