DCBLD2 Antibody

說明書

中文名稱：

DCBLD2兔多克隆抗體
貨號：

CSB-PA006535GA01HU
規(guī)格：

￥3,900
其他：

產(chǎn)品詳情
產(chǎn)品評價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情

產(chǎn)品詳情

Uniprot No.：

Q96PD2
基因名：

DCBLD2
別名：

1700055P21Rik antibody; AW146002 antibody; CLCP1 antibody; coagulation factor V/VIII-homology domains protein 1 antibody; CUB and LCCL domain-containing protein 2 antibody; CUB antibody; CUB; LCCL and coagulation factor V/VIII-homology domains protein 1 antibody; DCBD2_HUMAN antibody; DCBLD2 antibody; Discoidin antibody; discoidin CUB and LCCL domain containing 2 antibody; Discoidin; CUB and LCCL domain-containing protein 2 antibody; Endothelial and smooth muscle cell-derived neuropilin-like protein antibody; ESDN antibody; LCCL and coagulation factor V/VIII-homology domains protein 1 antibody
宿主：

Rabbit
反應(yīng)種屬：

Human,Mouse,Rat
免疫原：

Human DCBLD2
免疫原種屬：

Homo sapiens (Human)
抗體亞型：

IgG
純化方式：

Antigen Affinity Purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

ELISA,WB
Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

基因功能參考文獻(xiàn)：
1. Dynamic multi-site phosphorylation by Fyn and Abl drives the interaction between CRKL and the novel scaffolding receptors DCBLD1 and DCBLD2. PMID: 29025973
2. DCBLD2 protein expression profiles were compared between 11 invasive and non-invasive myxofibrosarcomas. Higher DCBLD2 expression was significantly associated with invasive properties of tumor cells. The expression level of DCBLD2 was consistent in different portions of tumor tissues. PMID: 28668639
3. phosphorylation of DCBLD2 Y750 recruited TRAF6, leading to increased TRAF6 E3 ubiquitin ligase activity and subsequent activation of AKT, thereby enhancing EGFR-driven tumorigenesis PMID: 25061874
4. ESDN associates with VEGFR-2 and regulates its complex formation with negative regulators of VEGF signaling, protein tyrosine phosphatases PTP1B and TC-PTP, and VE-cadherin. PMID: 24177422
5. SFK activity was shown to be sufficient, but not required for the interaction between ESDN and the CrkL-SH2 domain PMID: 23770091
6. ESDN and AP-2g expression is lower in thick melanomas, it is associated with unfavourable histo-pathological parameters (increased vascularity, vascular invasion and mitoses) and correlates with a shorter DFS like for AP-2a. PMID: 23036739
7. These findings suggest that DCBLD2 could be a potential marker and drug target for treatment of nasal polyposis in Korean asthma patients. PMID: 22261696
8. Seven SNPs (rs1371687, rs7615856, rs828621, rs828618, rs828616, rs1062196, and rs8833) and one haplotype (DCBLD2-ht1) show associations with susceptibility to AERD. PMID: 22468095
9. The full-length signal peptides of DCBLD2 is functional and furthermore that the C-domains are sufficient and essential for ER targeting, whereas the N-domains are dispensable. Thus, the N-domains are available for additional functions. PMID: 21183991
10. our study is the first to identify and validate Endofin, DCBLD2, and KIAA0582 as part of a complex EGF phosphotyrosine signaling network PMID: 17570516
11. ESDN expression was significantly higher in proliferating, as compared to growth-arrested cells. ESDN overexpression in VSMC led to a decline in growth curves, while ESDN knock down had the opposite effect. PMID: 17697260
12. These data suggest that down-regulation of DCBLD2, often associated with promoter hypermethylation, is a frequent event that may be related to the development of gastric cancer. PMID: 18314483
13. ESDN modulates PDGF signaling in VSMCs via regulation of PDGFR beta surface levels. PMID: 19696027
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亞細(xì)胞定位：

Membrane; Single-pass type I membrane protein.
組織特異性：

Highly expressed in testis, heart, skeletal muscle and also in cultured vascular smooth muscle cells.
數(shù)據(jù)庫鏈接：

HGNC: 24627

OMIM: 608698

KEGG: hsa:131566

STRING: 9606.ENSP00000321573

UniGene: Hs.203691

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