Col1a1 Antibody

^{Rare Species}

中文名稱：

Col1a1兔多克隆抗體
貨號：

CSB-PA005727YA01RA
規格：

￥440
圖片：
Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA005727YA01RA at dilution of 1:20
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Rattus norvegicus (Rat) Col1a1 Polyclonal antibody
Uniprot No.：

P02454
基因名：

Col1a1
別名：

Col1a1Collagen alpha-1(I) chain antibody; Alpha-1 type I collagen antibody
宿主：

Rabbit
反應種屬：

Rat, Human
免疫原：

Recombinant Rat Collagen alpha-1(I) chain protein (955-1207AA)
免疫原種屬：

Rattus norvegicus (Rat)

標記方式：

Non-conjugated

本頁面中的產品，Col1a1 Antibody (CSB-PA005727YA01RA)，的標記方式是Non-conjugated。對于Col1a1 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA005727YB01RA	Col1a1 Antibody, HRP conjugated	ELISA
FITC	CSB-PA005727YC01RA	Col1a1 Antibody, FITC conjugated
Biotin	CSB-PA005727YD01RA	Col1a1 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, IHC

推薦稀釋比：

Application	Recommended Dilution
IHC	1:10-1:100

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Type I collagen is a member of group I collagen (fibrillar forming collagen).
基因功能參考文獻：
1. the activation of Pin1 promoted cardiac extracellular matrix deposition and oxidative stress damage by regulating the phosphorylation of the MEK1/2ERK1/2 signaling pathway and the expression of alphaSMA. PMID: 29286102
2. In vitro analysis using LX2 HSC cells indicated that ATII can augment TGFbeta1 and collagen type I alpha1 mRNA expression via periostin expression, suggesting that the interaction between ATII and periostin may serve a role in liver fibrosis development. In conclusion, blockade of ATIIinduced periostin may suppress the progression of liver fibrosis development. PMID: 28849131
3. miR21 regulates expression of alphaSMA and collagen I in activated rat hepatic stellate cells by directly targeting Smad7. PMID: 28731181
4. Taken together, the lentiviral RNAi vector targeting the TGF beta-1 gene of rats was successfully constructed, which effectively silenced the TGF beta-1 gene of the HSCT6 cells and inhibited the expression of Col1a1. PMID: 28713909
5. the diagnostic value of urinary collagen degradation products in a proteinuria-driven fibrosis rat model, was investigated. PMID: 28320405
6. Brefeldin A induced a significant up-regulation of Col1a1 mRNA levels in CFSC-2G hepatic stellate cells that was time-dependent. The UPR correlated with enhanced mRNA and protein levels of collagen type I in these cells. Analysis of the 3 branches of UPR revealed the activation of IRE1alpha, PERK and ATF6 in response to BFA. An IRE1alpha-p38 MAPK-Smad pathway may be responsible for the fibrogenic action of BFA on HSC. PMID: 27155082
7. treatment with LG ameliorated STZ-induced DN via the inhibition of oxidonitrosative stress as well as downregulation of KIM-1, NGAL, TGF-beta1, and collagen-1 mRNA expressions. PMID: 27756197
8. In a liver fibrosis cellular model, tenascin-C promotes migration of hepatic stellate cells and production of type I collagen via TGF-beta1 and alpha9beta1 integrin pathway. PMID: 27031437
9. Liganded vitamin D receptor through its interacting repressor inhibits the expression of Col1a1. PMID: 27351590
10. In a pure VO model, chymase produced in adult cardiac fibroblasts leads to autophagic degradation of newly synthesized intracellular procollagen I, suggesting a new role of chymase in extracellular matrix degradation PMID: 26807691
11. signaling through Na/K-ATPase regulates miRNAs and specifically, miR-29b-3p expression both in vivo and in vitro. PMID: 26702050
12. A reciprocal regulatory relationship between DDR2 and collagen, involving cross-talk between the GPCR and RTK pathways, is central to Angiotensin II-induced increase in collagen expression in cardiac fibroblasts. PMID: 26674152
13. Preferential sites for intramolecular glucosepane cross-link formation in type I collagen has been described. PMID: 26049074
14. The present findings suggest that prolyl 3-hydroxylation incrementally regulates collagen fibril diameter in tendon. PMID: 26567337
15. Flouride affected collagen I arrangement and produced ultrastructural changes in bone tissue. Meanwhile, the mRNA expression of COL1A1 and COL1A2 were reduced and the COL I protein levels decreased in the fluorosis group. PMID: 25655816
16. High Collagen Type I expression is associated with renal fibrosis in experimental kidney diseases. PMID: 25784725
17. Increased expression of Acan and Col2a1 along with decreased expression of Col1a1 and Mmp13 indicated formation of hyaline cartilage in this group. PMID: 25128628
18. These data support the hypotheses that, in dentin, the interaction between COL1 and PP may initiate crystal nucleation and that additional interactions between PP and the growing crystals may modulate the crystal growth pattern and crystal size. PMID: 15609627
19. Fetal and adult human skin fibroblasts retain their differential proliferative response to TGF-beta when cultured in the presence of fibronectin and unpolymerized or polymerized collagen. PMID: 24735795
20. Regional differences in cell proliferation and fibronectin structure were dependent on both soluble fibronectin concentration and fibronectin-collagen type I interactions. PMID: 24116223
21. This study suggests that laminin and type I collagen support the function of folliculostellate cells by increasing fibromodulin protein expression in the anterior pituitary. PMID: 23959432
22. The naive effector cells of collagen type I during acute experimental pancreatitis are acinar cells and not pancreatic stellate cells PMID: 24036265
23. Data suggest that miR-711-SP1-collagen-I pathway may be strategies for miRNA-based anti-fibrotic drug research. PMID: 23633075
24. The DNMT-mediated DNA methylation is an important mechanism in regulating the TGF-beta1-induced COL1A1 gene expression. PMID: 23560091
25. Hypothesized that reducing collagen I accumulation in glomerulosclerosis would lower Hic-5 expression,reducing apoptosis, and maintain glomerular integrity. NTU281 treatment reduced glomerular col I accumulation, Hic-5 and alpha-SMA expression, and apoptosis. PMID: 23508044
26. These findings suggest that amide I nonlinear optical chiral effects in type I collagen assemblies arise predominantly from the chiral organization of amide chromophores within individual collagen molecules, rather than from supramolecular structures. PMID: 23200051
27. Hypoxia alone can upregulate DNA synthesis and expression of collagen type I and III mRNA in adult rat cardiac fibroblasts. PMID: 21166192
28. Crystal structures of Hsp47 in its free form and in complex with homotrimeric synthetic collagen model peptides, are presented. PMID: 22847422
29. Curcumin could suppress bleomycin-induced pulmonary fibrosis by inhibiting the synthesis and deposition of type I collagen and reducing expression of TGF-beta1. PMID: 18727865
30. These data demonstrate a relationship between miR-133a and Col1A1, suggesting that myocardial fibrosis occurring in Ang II-dependent hypertension is regulated by the down-regulation of miR-133a and miR-29b through the modulation of Col1A1 expression. PMID: 21769867
31. S-adenosyl-L-methionine inhibits Col1A1 processing leading to increased ubiquitination and decreased secretion. PMID: 21645221
32. The regulatory effect of melatonin (MLT)cannot be explained by its effect on procollagen gene expression, since neither MLT nor pinealectomy is shown to have an influence on alpha1 (I) and alpha1 (III) procollagen mRNA content in the scar. PMID: 20388018
33. High fat diet reduces the levels of type I tropocollagen and adiponectin and these effects are deleterious for skin function. PMID: 20397200
34. Bushen Rougan Recipe can decrease the expressions of collagen type I and CTGF mRNAs in rats with hepatic fibrosis. PMID: 18782537
35. Craniofacial growth and type I collagen gene expresion in the rat occur mainly between days 10 and 21. PMID: 20149607
36. AT2 receptor is involved in collagen metabolism in cardiac fibroblasts by regulating the levels of Col I and TIMP-1 mRNA. PMID: 18095594
37. Data support that post-translational glycosylation of collagen I has a role in the induction in endothelial cells in vitro of molecules conductive to self-organization in vessels-like structures. PMID: 20006603
38. Deducted interpretations from our experimental approach suggest that Ang II stimulates indirectly (via SNS) and inhibits directly (via AT1 receptors) the collagen type I at transcriptional and protein levels. PMID: 19679517
39. Type I collagen gene expression is affected by mechanical loading. PMID: 11924646
40. Gene expression of TGF-beta1, type I collagen, and connective tissue growth factor using primary cultured pancreatic stellate cells. PMID: 12199527
41. p38 MAPK mediates the regulation of alpha1(I) procollagen mRNA levels by TNF-alpha and TGF-beta in a cell line of rat hepatic stellate cells PMID: 12297293
42. hypoxic enhancement of the posttranscriptional step of collagen synthesis contributed to the accelerated deposition of collagen fibrils PMID: 12408871
43. dental pulp contains competent progenitor cells capable of differentiating into new generations of odontoblast-like cells which express high levels of Col1a1-2.3-GFP PMID: 12755333
44. TRAM2, as a part of the translocon, is required for the biosynthesis of type I collagen by coupling the activity of SERCA2b with the activity of the translocon PMID: 14749390
45. both p38 MAPK and Smad signaling independently and additively regulate alpha1(I) collagen gene expression by transcriptional activation PMID: 15647278
46. Results show that 70-kDa ribosomal S6 kinase plays a crucial role in hepatic stellate cell proliferation, collagen type I expression, and cell cycle control, thus representing a potential therapeutic target for liver fibrosis. PMID: 15677443
47. Results conclude that residues 19-46 of bone sialoprotein represent a novel collagen-binding site. PMID: 15703183
48. Endo180 binds to the C-terminal region of type I collagen, and this interaction appears to play an important role in cell-matrix adhesion PMID: 15817460
49. Our results demonstrate that inhibition of alphaI(I)-collagen gene expression by curcumin in activated HSCs results from suppression of CTGF gene expression through increasing cellular GSH contents and interruption of TGF-beta signaling. PMID: 16306131
50. Data present a crystallographic determination of the collagen type I supermolecular structure. PMID: 16751282
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亞細胞定位：

Secreted, extracellular space, extracellular matrix.
蛋白家族：

Fibrillar collagen family
組織特異性：

Forms the fibrils of tendon, ligaments and bones. In bones the fibrils are mineralized with calcium hydroxyapatite.
數據庫鏈接：

KEGG: rno:29393

STRING: 10116.ENSRNOP00000005311

UniGene: Rn.2953

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