Cleaved-MMP10 (F99) Antibody
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中文名稱：Cleaved-MMP10 (F99)兔多克隆抗體
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貨號：CSB-PA000048
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規格：￥1090
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圖片：
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Western Blot analysis of HepG2 cells using Cleaved-MMP-10 (F99) Polyclonal Antibody -
Western Blot analysis of NIH-3T3 cells using Cleaved-MMP-10 (F99) Polyclonal Antibody
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其他：
產品詳情
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Uniprot No.：
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基因名：MMP10
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別名：Matrix metallopeptidase 10 (stromelysin 2) antibody; Matrix metalloprotease 10 antibody; Matrix metalloproteinase 10 (stromelysin 2) antibody; Matrix metalloproteinase 10 antibody; Matrix metalloproteinase-10 antibody; MMP 10 antibody; MMP-10 antibody; Mmp10 antibody; MMP10_HUMAN antibody; SL 2 antibody; SL-2 antibody; SL2 antibody; STMY 2 antibody; STMY2 antibody; Stromelysin 2 antibody; Stromelysin II antibody; Stromelysin-2 antibody; Stromelysin2 antibody; StromelysinII antibody; Transin 2 antibody; Transin-2 antibody; Transin2 antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Synthesized peptide derived from the Internal region of Human MMP-10.
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
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抗體亞型：IgG
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純化方式：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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產品提供形式：Liquid
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應用范圍：WB, ELISA
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推薦稀釋比：
Application Recommended Dilution WB 1:500-1:2000 ELISA 1:40000 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Can degrade fibronectin, gelatins of type I, III, IV, and V; weakly collagens III, IV, and V. Activates procollagenase.
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基因功能參考文獻：
- increased abundance of Snail and Axin2 is highly correlated to malignant transformation of OL, making them novel biomarker(s) predicting oral cancer development PMID: 28939077
- MMP10, either alone or in combination with tPA, might represent a new strategy for thrombolysis in ischemic stroke, providing higher protection against cerebrovascular damage. PMID: 28379489
- There is a significant association in the expression of P-Rex1 and MMP10 in human luminal breast cancer, and their co-expression is indicative of poor prognosis. PMID: 27351228
- MMP10 is a novel marker for cancer stem-like cells (CSCs)/cancer-initiating cells in epithelial ovarian cancer PMID: 27072580
- Data show that AJUBA upregulated MMP10 and MMP13 expression in esophageal squamous cell carcinoma (ESCC). PMID: 27172796
- MMP10 is overexpressed in the serum and pulmonary arteries of patients with systemic sclerosis-associated pulmonary hypertension. PMID: 28805015
- Using a quantum chemical approach method, it has been established that mutations in MMP-10 and FGA proteins led to substantial energetic modifications suggesting an impact on their functions and/or stability in the recurrent pregnancy loss patients. PMID: 29016666
- These results indicate that MMP10 serves a beneficial role in response to acute infection by moderating the proinflammatory response of resident and infiltrating macrophages. PMID: 27316687
- Mycobacterium tuberculosis activates inflammatory and stromal cells to secrete MMP-10, and this is partly driven by the virulence factor early secretory antigenic target-6. PMID: 27654284
- MMP10 expression is significantly upregulated in human masticatory mucosa during wound healing. PMID: 28005267
- Our results suggest that the level of the MMP-10 expression in tumor epithelium of cutaneous squamous cell carcinoma and basal cell carcinoma may contribute to the different invasive patterns observed in these tumors PMID: 27567711
- these results suggest that TGF-beta1 stimulates HSC-4 cell invasion through the Slug/Wnt-5b/MMP-10 signalling axis. PMID: 26861993
- the rs17435959 polymorphism of the MMP-10 gene may be associated with an increased risk of pelvic organ prolapse (POP). PMID: 26419737
- According to this study, the expression of ST-2 is associated with histopathological grade and tumor differentiation in head and neck squamous cell carcinomas. PMID: 26625808
- MMP-10 may be a novel biomarker reflecting both disease severity and prognosis in patients with idiopathic pulmonary fibrosis. PMID: 26415518
- Noncomplicated PVVs are associated with systemic, prothrombotic activation of hemostasis and increased concentration of MMP-10, suggesting a prothrombotic and proinflammatory state. PMID: 24413984
- Up-regulation of matrix metalloproteinase 10 is associated with colitis-associated cancer. PMID: 25742789
- hepatocellular carcinoma cells stably expressing MMP10 had increased CXCR4 expression and migratory capacity PMID: 25808184
- No association was found between MMP10 C/T rs486055 variants and anterior cruciate ligament rupture. PMID: 21410539
- Suggest that MMP-10 is associated with severity and poor outcome in peripheral arterial disease. PMID: 25441671
- Taken together, our findings show that MMP-10 can play a significant role in tumor growth and progression, and that MMP-10 perturbation may represent a rational strategy for cancer treatment. PMID: 24885595
- YY1 suppresses invasion and metastasis of pancreatic ductal adenocarcinoma by downregulating MMP10 in a MUC4/ErbB2/p38/MEF2C-dependent mechanism. PMID: 24884523
- Preliminary evidence suggests that MMP-10 may be a mediator of the number of depressive phases during bipolar disorder PMID: 24576976
- Chrysin downregulates matrix metalloproteinase-10 in triple-negative breast cancer cells. PMID: 24122885
- Data suggest that MMP10 promotes differentiation of myoblasts into osteoblasts by up-regulating BMP2/Smad6/Smad7 (bone morphogenetic protein 2) signaling pathway and gene expression of proteins found in bone (collagen, type I; osterix; osteocalcin). PMID: 24077220
- MMP-10 is involved in the development of microvascular complications in type 1 diabetes and emerges as a potential therapeutic target for slowing down the evolution of diabetic nephropathy and retinopathy. PMID: 24078057
- Marked induction of matrix metalloproteinase-10 by respiratory syncytial virus infection in human nasal epithelial cells. PMID: 24009192
- rs17435959 of the MMP-10 gene is associated with carotid vulnerable plaque. PMID: 24327153
- serum proMMP-10 after acute ischemic stroke is associated with TNFalpha and may have a role in brain damage and poor outcome PMID: 23742289
- Small hairpin RNA silencing of proteinases overexpressed in diabetic corneas enhanced corneal epithelial and stem cell marker staining and accelerated wound healing. PMID: 24255036
- COOH truncation of the hepatitis B virus X protein, plays a role in enhancing cell invasiveness and metastasis in hepatocellular carcinoma by activating MMP10 through C-Jun. PMID: 22821423
- Findings suggest that MMP10 plays an important role in esophageal squamous cell carcinoma progression in the early stage, and overexpression of MMP10 in tumor tissues could be used as a potential prognostic marker in the early clinical stage of ESCC. PMID: 22121946
- High MMP-10 is associated with malignant pleural effusion. PMID: 22524815
- Analysis of gene expression data from human cancers reveals a strong positive correlation between tumor Mmp10 expression and metastatic behavior in many human tumor types. PMID: 22545096
- Data show that TIMP-1 inhibits the MMP-10 with a K(i) of 1.1 x 10(-9) M, and TIMP-2 inhibits the MMP-10 with a K(i) of 5.8 x 10(-9) M. PMID: 22427646
- Thrombin/CD40L elicited a strong synergistic effect on endothelial MMP-10 expression and microparticles containing MMP-10 in vitro and in vivo, which may represent a new link between inflammation/thrombosis with prognostic implications. PMID: 22492089
- MMP-10 was capable of enhancing tissue plasminogen activator-induced fibrinolysis via a thrombin-activatable fibrinolysis inhibitor inactivation-mediated mechanism. PMID: 22104553
- the roles of MMP-10 in the invasion of head and neck squamous cell carcinoma cells in vitro PMID: 21998657
- Mmp10 is overexpressed in lung tumors induced by either the smoke carcinogen urethane or oncogenic Kras. PMID: 22022614
- Enhanced expression of MMP-10 is associated with progression from non-dysplastic Barrett's oesophagus to adenocarcinoma. PMID: 20584750
- Data demonstrate induction of MMP-10 by VEGF in HUVEC and support an angiogenic role for MMP-10 in response to VEGF stimulation in vitro and in vivo. PMID: 20432469
- Results suggest that MMP-10 may be important in the initial stages of squamous cell cancer progression and induced in the stroma relating to the general host-response reaction to skin cancer. PMID: 19601983
- MMP-10 and MMP-26, in particular, may associate with aggressive Merkel cell carcinoma. PMID: 19921252
- The catalytic domain of human matrix metalloproteinase-10 (MMP-10) has been expressed in Escherichia coli and its crystal structure solved at 2.1 angstroms resolution. PMID: 15095982
- Beta-carotene suppresses UVA-induction of MMP-10. PMID: 15288123
- a tightly regulated expression level of stromelysin-2 is required for limited matrix degradation at the wound site PMID: 15371548
- Overexpression of MMP-10 is associated with non-small cell lung cancer PMID: 15375490
- identified significant interactions between MMP10 (nt+180) polymorphisms and gender in abdominal aortic aneurysm PMID: 15944607
- zinc finger protein 267 as a negative transcriptional regulator of MMP-10 might promote liver fibrogenesis PMID: 16054593
- Increased levels of MMP-10 is associated with gastric cancer PMID: 16331256
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亞細胞定位：Secreted, extracellular space, extracellular matrix.
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蛋白家族：Peptidase M10A family
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數據庫鏈接：
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