Cd207 Antibody

中文名稱：

Cd207兔多克隆抗體
貨號：

CSB-PA837695LA01MO
規(guī)格：

￥440
其他：

產(chǎn)品詳情
產(chǎn)品評價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情

產(chǎn)品詳情

產(chǎn)品名稱：

Rabbit anti-Mus musculus (Mouse) Cd207 Polyclonal antibody
Uniprot No.：

Q8VBX4
基因名：

Cd207
別名：

Cd207 antibody; Clec4kC-type lectin domain family 4 member K antibody; Langerin antibody; CD antigen CD207 antibody
宿主：

Rabbit
反應(yīng)種屬：

Mouse
免疫原：

Recombinant Mouse C-type lectin domain family 4 member K protein (63-331AA)
免疫原種屬：

Mus musculus (Mouse)

標(biāo)記方式：

Non-conjugated

本頁面中的產(chǎn)品，Cd207 Antibody (CSB-PA837695LA01MO)，的標(biāo)記方式是Non-conjugated。對于Cd207 Antibody，我們還提供其他標(biāo)記。見下表：

標(biāo)記方式	貨號	產(chǎn)品名稱	應(yīng)用
HRP	CSB-PA837695LB01MO	Cd207 Antibody, HRP conjugated	ELISA
FITC	CSB-PA837695LC01MO	Cd207 Antibody, FITC conjugated
Biotin	CSB-PA837695LD01MO	Cd207 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

ELISA
Protocols：

ELISA Protocol
儲(chǔ)存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

功能：

Calcium-dependent lectin displaying mannose-binding specificity. Induces the formation of Birbeck granules (BGs); is a potent regulator of membrane superimposition and zippering. Binds to sulfated as well as mannosylated glycans, keratan sulfate (KS) and beta-glucans. Facilitates uptake of antigens and is involved in the routing and/or processing of antigen for presentation to T cells.
基因功能參考文獻(xiàn)：
1. Binding analysis between purified long and short forms of langerin and a series of keratin sulfate disaccharide components shows that the binding critically requires the 6-sulfation of Gal and that the long form of langerin displays higher affinity than the short form. PMID: 29631057
2. Bacterial Polysaccharide Specificity of the Pattern Recognition Receptor Langerin Is Highly Species-dependent PMID: 27903635
3. Data show that Candida albicans and Candida tropicalis preferentially localized in (and persisted within) a sub- population of Peyer's patch Langerin-positive dendritic cells. PMID: 26386376
4. Langerin is expressed by the XCR1(+) "DC1" population of mice. PMID: 25516751
5. Langerin+ dermal dendritic cells appear to be site- and strain-specific PMID: 24629018
6. model of epicutaneous ovalbumin sensitization inducing an inflammatory skin resembling atopic dermatitis (AD) to explore the role of CD207 in the pathogenesis of AD PMID: 23117802
7. Langerin-positive dendritic cells appear to be the predominant, though not exclusive, population responsible for in vivo transport of anti-DEC-205 antibodies from the skin to the draining lymph nodes in steady state and inflammation. PMID: 22291181
8. Data demonstrated that CD207(+) CD8alpha(+) thymic DCs do not share a common origin with T cells but originate from intrathymic precursors. PMID: 21630253
9. The normal corneal epithelium is endowed with CD11c(+) Langerin+ cells that are LCs, whereas the stroma is endowed with a separate population of (non-LC) Langerin+ DCs. PMID: 21482644
10. Langerhan cells and (Langerin(+)) dermal dendritic cells thus seem to have a redundant function in regulating contact hypersensitivity PMID: 20703247
11. molecular cloning and expression of Langerin transcripts in dendritic cells PMID: 11978773
12. Developmentally regulated expression of Langerin isoforms provides a mechanism by which Langerin involvement in antigen uptake and processing could be regulated. PMID: 15191546
13. CD207 has a role in maintaining Birbeck granules but not in Langerhans cell function PMID: 15601833
14. Langerin may have an unanticipated role in cell-matrix interactions that modulate LC development, localization, or function PMID: 16557233
15. CD207 antigens manifest a high degree of colocalization around the nucleus of the Langerhans cells. PMID: 16941665
16. langerin(+) DCs patrol the dermis in the steady state and migrate to the skin DLNs charged with skin antigens PMID: 18086862
17. dermal Langerin(+) dendritic cells (DCs) are radiosensitive and display a distinct cell surface phenotype PMID: 18086865
18. Depletion of langerin(+) cells impaired intestinal IgA Ab responses after Topical transcutaneous immunization PMID: 18354155
19. Langerin(+) cells do promote T cell responses to skin Ags PMID: 18354196
20. In a knockin-mouse model of the immune response against Leishmania major parasites, langerin-expressing dendritic cells are, in general, dispensable for an efficient adaptive immune response against L. major parasites. PMID: 19124720
21. Despite a marginal zone location, CD207(+) DCs lacked identifying molecules for 3 different types of macrophages, localized in proximity and, in contrast to macrophages, marginal zone DCs were poor scavengers of soluble and particulate substrates PMID: 19168629
22. Langerhans cells(LC) and langerin(+) dermal dendritic cells(DC) represent distinct DC subsets that have specialized functions and that LC are important immunoregulatory cells PMID: 19218433
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亞細(xì)胞定位：

Membrane; Single-pass type II membrane protein.
組織特異性：

Expressed by Langerhans cells. Expressed in dendritic cells and by scattered cells in lymph nodes and spleen. Also detected in some non-lymphoid tissues such as lung, liver and heart.
數(shù)據(jù)庫鏈接：

KEGG: mmu:246278

STRING: 10090.ENSMUSP00000040746

UniGene: Mm.136079

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