CYP2B6 Antibody
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中文名稱：CYP2B6兔多克隆抗體
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貨號：CSB-PA212733
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規格：￥2024
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圖片：
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Western blot analysis of extracts from HT-29 cells, using Cytochrome P450 2B6 antibody.
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) CYP2B6 Polyclonal antibody
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Uniprot No.：
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基因名：CYP2B6
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宿主：Rabbit
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反應種屬：Human
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免疫原：Synthesized peptide derived from internal of Human Cytochrome P450 2B6.
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免疫原種屬：Homo sapiens (Human)
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克隆類型：Polyclonal
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純化方式：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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濃度：It differs from different batches. Please contact us to confirm it.
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產品提供形式：Liquid
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應用范圍：ELISA,WB
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推薦稀釋比：
Application Recommended Dilution WB 1:500-1:3000 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：A cytochrome P450 monooxygenase involved in the metabolism of endocannabinoids and steroids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the epoxidation of double bonds of arachidonoylethanolamide (anandamide) to 8,9-, 11,12-, and 14,15-epoxyeicosatrienoic acid ethanolamides (EpETrE-EAs), potentially modulating endocannabinoid system signaling. Hydroxylates steroid hormones, including testosterone at C-16 and estrogens at C-2. Plays a role in the oxidative metabolism of xenobiotics, including plant lipids and drugs. Acts as a 1,4-cineole 2-exo-monooxygenase.; Allele 2B6*9: Has low affinity for anandamide and can only produce 11,12 EpETrE-EAs.
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基因功能參考文獻：
- Case Reports: CYP2B6-deficient alleles may be responsible for an increased conversion of ifosfamide into neurotoxic metabolites, leading to encephalopathy. PMID: 29319893
- The concentration-time curve (AUC(0(R)96)), maximum plasma concentration (Cmax), and terminal half-life (t1/2) values of Bupropion in CYP2B6*1/*4 were lower than those of CYP2B6*1/*1. The hydroxybupropion (HBUP) Cmax values in CYP2B6*4/*6 and CYP2B6*1/*4 increased by 1.12-fold and 1.97-fold, whereas the HBUP Cmax value in CYP2B6*1/*6 decreased to a value 1.64-fold lower than that in CYP2B6*1/*1 PMID: 29637923
- CYP2B6-efavirenz analog complex provides a useful platform to investigate computationally as well as biophysically the effect of genetic polymorphisms on binding of the widely studied efavirenz. PMID: 29596329
- results indicate that the amino acid substitutions in the CYP2B6 variants suppressed the metabolic activation of CPS. CYP2B6 variants have altered capacity to bioactivate CPF and may affect individual susceptibility of CPF PMID: 29463407
- The findings of this study indicate that CYP2B6 contribute to the metabolism of MDMA to MDA in humans PMID: 28117133
- The first data of several CYP2B6 polymorphisms in Roma population. PMID: 29095103
- With consensus recommendations on downregulation, CYP2C induction, and CYP2B6 positive control. PMID: 28646080
- Genotyping of CYP2B6 may therefore be of value when assessing dose requirements in methadone maintenance treatment. PMID: 28723731
- Genomic variation in CYP2B6 may explain, at least in part, severity of Neonatal Abstinence Syndrome PMID: 28320034
- CYP2B6 haplotype predicts efavirenz plasma concentration in black South African HIV-1-Infected children. PMID: 28816644
- This is the first study that investigated the impact of the 516 G>T polymorphism of the CYP2B6 gene among HIV-positive individuals from southern Brazil. Its clinical significance indicates the need for prospective studies in this population. PMID: 28492729
- G(516)T CYP2B6 polymorphisms was associated with Bronchopulmonary Dysplasia susceptibility in Preterm Neonates. PMID: 28081574
- The deficient CYP2B6 516 T allele is associated with higher efavirenz plasma drug levels and more frequent central nervous system-related symptoms. PMID: 28145050
- Males with the CYP2B6 *6/*6 genotype may be less susceptible to the development of anti-tuberculosis drug-induced hepatotoxicity. PMID: 28389387
- CYP2B6 interindividual variability was not significantly associated with genetic variation in CYP2B6, nor was it associated with differences in gender or ethnicity, suggesting that factors other than these are largely responsible for the wide range of variability in CYP2B6 expression and activity observed among a large group of individuals/samples. PMID: 26608082
- Established the regression models for CYP3A4 and CYP2B6 inductions in human hepatocytes using azole compounds. PMID: 27208383
- Phe206 plays a crucial role in determining the specificity of CYP2B6. PMID: 27538916
- Homozygous carriers of CYP2B6*6 allele may be at increased risk for EFV-induced QT interval prolongation via inhibition of hERG. PMID: 27333947
- Genetic variations in CYP2B6 affect induction of Bupropion hydroxylation by sodium ferulate. PMID: 23840296
- CYP2B6 SNPs are associated with methadone fatalities. contributes to a poor metabolizer phenotype for methadone in these fatal cases PMID: 28184434
- CYP2B6 rs2279343 may predict event-free survival in rhabdomyosarcoma PMID: 27388155
- It has been established that cytochrome P4502B6 (CYP2B6) is the major isoform catalyzing both ketamine N-demethylation and ketamine metabolism overall in vitro at therapeutic concentrations and clinically. PMID: 27763887
- polymorphism c.516G>T in the CYP2B6 gene and BMI affect the metabolism rate of propofol and may play an important role in the optimisation of propofol anaesthesia PMID: 27826892
- his cross-sectional, pharmacogenetic candidate, gene pilot study recruited 75 patients having minor elective outpatient surgeries. EP was measured with the Clinician Administered Dissociative State Scale. Genetic association of CYP2B6*6 and GRIN2B (rs1019385 and rs1806191) single-nucleotide polymorphisms and ketamine-induced EP occurrence and severity were tested using logistic and linear regression. PMID: 28252572
- Data suggest that A785G CYP2B6 gene polymorphisms and specific CYP2B6 haplotypes may be a risk factor for the pathogenesis of AML, especially secondary AML as well as for the induction of AML chromosomal aberrations. PMID: 27865701
- Results show that CYP2B6 slow metabolizer genotypes were significantly associated with efavirenz induced central nervous system symptoms. PMID: 27509478
- The possible influence of CYP2B6 c.516G>T genetic variant on propofol dose. PMID: 26141406
- Around 450 and 250 mg daily doses might meet EFV dosing needs of HIV-TB infected Ugandans in general and CYP2B6*6/*6 genotypes, respectively. PMID: 27045425
- CYP2B6 polymorphisms were associated with lower and higher plasma concentrations in pregnant and postpartum women. PMID: 27195527
- Analysis of gene-gene interactions with CYP2B6 was particularly useful to reinforce the role of MRP4 and to reveal unknown associations, such as that of DRD3. PMID: 27665700
- POR rs2868177 and CYP2B6*6 variants contribute to the interindividual variability in human CYP2B6 activity, which may affect the disposition and interaction of other CYP2B6 substrate drugs PMID: 27439448
- CYP2B6*6 and *9 variant alleles had a significant decreasing effect on sertraline metabolism in major depression patients. PMID: 26830411
- Combined 3D-QSAR and docking procedures yielded precise information about the common and distinct interactions of inhibitors and the enzyme active sites of CYP2B6. PMID: 26648056
- the cytochrome P450 oxidoreductase g.6593A>G polymorphism significantly influences CYP2B6 activity PMID: 26580670
- Observation in Chinese patients with systemic lupus erythematosus indicated that the combination genetic marker of CYP2C19*2 and CYP2B6 -750 T > C genotypes was associated with 4-OH-CPA plasma concentration, short term efficacy and adverse reactions of cyclophosphamide. PMID: 26456622
- Data suggest that primary cytochrome P450 in liver microsomes catalyzing 9-hydroxylation of (-)-cis- and (-)-trans-rose oxide is CYP2B6 (and CYP2C19 to some extent); rose oxide is aroma compound from essential oils and is used in food and perfume. PMID: 26126958
- CYP2B6 516G>T SNP is prevalent in Aregntinian population. PMID: 26681005
- Both Cyp2b6 CT/TT genotype of rs8192719 (c.1294 + 3C > T) and AG genotype of rs2279343 (c.785A > G) prolonged survival (p < 0.05). PMID: 26602960
- Data suggest peripheral ligand-binding pocket and active site are located on opposite sides of the I-helix in CYP2B6; similar results were obtained for CYP2B4. PMID: 26982502
- Report shift in substrate specificity with sequence element swaps between CYP2B6 and CYP2B11. PMID: 27015760
- gene expression experiment revealed that CYP2B6, SPON1, and GSG1L can be activated concomitantly through a constitutive androstane receptor (CAR) activation pathway PMID: 27010727
- POR besides CYP2B6 can influence cyclophosphamide metabolism PMID: 26544874
- The CYP2B6*6 allele is associated with decrease plasma clearance and may be associated with a higher incidence of ketamine adverse effects. PMID: 25702819
- Average efavirenz concentrations of patients carrying ACTG (1.78 mug/mL), ACCT (7.50 mug/mL), and ATTG (1.92 mug/mL) haplotypes were markedly higher than those of patients carrying the CCTG haplotype. PMID: 26107645
- CYP2B6 Gene Polymorphism is not associated with Acute Myeloid Leukemia. PMID: 26107207
- The results provide evidence that the 516 TT homozygous genotype in the CYP2B6 gene presents a significant protective effect on the development of liver toxicity caused by anti-tuberculosis drugs. PMID: 25271170
- Studied the extent to which CYP2B6 and NAT2 polymorphisms were associated increased efavirenz concentrations in black and Hispanic patients enrolled from sub-Saharan Africa and South America. PMID: 25722197
- An increase in minor allele frequencies for CYP2B6 (and CYP2D6)was found in Roma population samples. PMID: 25933954
- significantly reduce the success of autologous HCT for lymphoma patients with the CYP2B6*5 variant. PMID: 25677220
- Functional importance of a peripheral pocket in mammalian cytochrome P450 2B enzymes. PMID: 26319176
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亞細胞定位：Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
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蛋白家族：Cytochrome P450 family
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組織特異性：Expressed in liver, lung and heart right ventricle.
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