CXXC1 Antibody
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中文名稱：CXXC1兔多克隆抗體
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貨號：CSB-PA868380DSR2HU
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規(guī)格：￥440
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圖片：
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Western blot
All lanes: CXXC-type zinc finger protein 1 antibody at 2μg/ml
Lane 1: THP-1 whole cell lysate
Lane 2: Mouse liver tissue
Lane 2: Mouse spleen tissue
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 76, 77 kDa
Observed band size: 76 kDa -
Immunohistochemistry of paraffin-embedded human colon tissue using CSB-PA868380DSR2HU at dilution of 1:100
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其他：
產(chǎn)品詳情
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產(chǎn)品名稱：Rabbit anti-Homo sapiens (Human) CXXC1 Polyclonal antibody
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Uniprot No.：
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基因名：CXXC1
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別名：2410002I16Rik antibody; 5830420C16Rik antibody; AI426635 antibody; CFP 1 antibody; CFP1 antibody; CpG binding protein antibody; CpG-binding protein antibody; CXXC 1 antibody; CXXC finger 1 antibody; CXXC finger 1 PHD domain antibody; CXXC finger protein 1 antibody; CXXC type zinc finger protein 1 antibody; CXXC-type zinc finger protein 1 antibody; CXXC1 antibody; CXXC1_HUMAN antibody; DNA binding protein with PHD finger and CXXC domain antibody; hCGBP antibody; HsT2645 antibody; PCCX 1 antibody; PCCX1 antibody; PHD finger and CXXC domain containing protein 1 antibody; PHD finger and CXXC domain-containing protein 1 antibody; PHF 18 antibody; PHF18 antibody; Protein containing CXXC domain 1 antibody; SPP 1 antibody; SPP1 antibody; ZCGPC 1 antibody; ZCGPC1 antibody; Zinc finger; CpG binding type containing 1 antibody
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宿主：Rabbit
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反應(yīng)種屬：Human, Mouse
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免疫原：Recombinant Human CXXC-type zinc finger protein 1 protein (1-210AA)
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免疫原種屬：Homo sapiens (Human)
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標(biāo)記方式：Non-conjugated
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：Antigen Affinity Purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
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產(chǎn)品提供形式：Liquid
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應(yīng)用范圍：ELISA, WB, IHC
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推薦稀釋比：
Application Recommended Dilution WB 1:500-1:5000 IHC 1:20-1:200 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產(chǎn)品評價
相關(guān)產(chǎn)品
靶點詳情
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功能：Transcriptional activator that exhibits a unique DNA binding specificity for CpG unmethylated motifs with a preference for CpGG.
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基因功能參考文獻：
- CFP1 binds open chromatin regions of active genes, including enhancers and non-CpG islands. PMID: 30292235
- directly controls the expression of key genes important for thymocyte survival, such as RORgammat, and for T-cell receptor signaling, including Zap70 and CD8, through maintaining the appropriate H3K4me3 on their promoters PMID: 27210293
- NF-kappaB recruitment enhanced the occupancy of the CpG island within the 14-3-3gamma promoter by CFP1.14-3-3gamma induction in CSR is enabled by the CFP1-mediated H3K4me3 enrichment in the promoter, dependent on NF-kappaB and sustained by E2A. PMID: 23851690
- The crescent-shaped CFP1 CXXC domain is wedged into the major groove of the CpG DNA, distorting the B-form DNA, and interacts extensively with the major groove of the DNA. PMID: 21407193
- CXXC finger protein 1 is a component of the mammalian Set1 histone H3-Lys4 methyltransferase complex PMID: 16253997
- CXXC finger protein 1 is required for normal proliferation and differentiation of the PLB-985 myeloid cell line. PMID: 17328666
- CGBP interacts with MLL1, MLL2 as well as Set1 H3-Lysine 4 (H3K4) specific methyl-transferases and plays critical roles in regulations of MLL target genes. PMID: 18082152
- study shows endogenous DNMT1 & CFP1 interact in vivo; CFP1 interaction with Setd1A or Setd1B not required for its interaction with DNMT1; result indicates CFP1 intersects cytosine methylation machinery independently of its association with Setd1 complexes PMID: 18680430
- expression of either the amino half of Cfp1 (amino acids 1 to 367 [Cfp1(1-367)]) or the carboxyl half of Cfp1 (Cfp1(361-656)) is sufficient to correct all of the defects observed with embryonic stem cells that lack Cfp1 PMID: 19433449
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亞細胞定位：Nucleus speckle. Nucleus. Note=Associated with euchromatin. During mitosis, excluded from condensed chromosomes.
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組織特異性：Ubiquitous.
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數(shù)據(jù)庫鏈接：
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