CTSH Antibody

中文名稱(chēng)：

CTSH兔多克隆抗體
貨號(hào)：

CSB-PA000033
規(guī)格：

￥1090
圖片：
Western Blot analysis of 293 cells using Cathepsin H Polyclonal Antibody
其他：

產(chǎn)品詳情
產(chǎn)品評(píng)價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情

產(chǎn)品詳情

Uniprot No.：

P09668
基因名：

CTSH
別名：

ACC 4 antibody; ACC 5 antibody; ACC4 antibody; ACC5 antibody; aleurain antibody; CATH_HUMAN antibody; cathepsin B3 antibody; cathepsin BA antibody; Cathepsin H heavy chain antibody; Cathepsin H light chain antibody; Cathepsin H mini chain antibody; CPSB antibody; CTSH antibody; minichain antibody; N benzoylarginine beta naphthylamide hydrolase antibody; N-benzoylarginine-beta-naphthylamide hydrolase antibody; pro cathepsin H antibody
宿主：

Rabbit
反應(yīng)種屬：

Human
免疫原：

Synthesized peptide derived from the Internal region of Human Cathepsin H.
免疫原種屬：

Homo sapiens (Human)
標(biāo)記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

WB, ELISA

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:2000
ELISA	1:20000

Protocols：

Western Blotting (WB) Protocol
ELISA Protocol
儲(chǔ)存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

功能：

Important for the overall degradation of proteins in lysosomes.
基因功能參考文獻(xiàn)：
1. the up-regulation of MMP genes is mediated through degradation of class IIa histone deacetylases (HDACs) by certain cysteine cathepsins (Cts). PMID: 28157489
2. Especially, rs3825932 in CTSH has integrative functional evidence supporting the association with type 1 diabetes mellitus. PMID: 26429317
3. p41 fragment is also shown to reduce the secretion of interleukin-12 (IL-12/p70) during the subsequent maturation of treated dendritic cells. PMID: 26960148
4. In conclusion, CTSH/rs3825932 and ERBB3/rs2292239 SNPs were associated with reduced risk of progression to proliferative diabetic retinopathy and two-step progression of diabetic retinopathy on the ETDRS scale accordingly. PMID: 26245339
5. mutation in LRPAP1 is associated with high myopia. Further studies are expected to evaluate the pathogenicity of the variants in CTSH, LEPREL1, ZNF644, SLC39A5, and SCO2. PMID: 25525168
6. The data provide strong evidence that CTSH is an important regulator of beta-cell function during progression of T1D PMID: 24982147
7. CtsH-mediated processing of talin might promote cancer cell progression by affecting integrin alphaVbeta3 activation and adhesion strength PMID: 23204516
8. The processing of procathepsin H is an autocatalytic, multistep process proceeding from an inactive 41kDa pro-form, through a 30kDa intermediate form, to the 28kDa mature form. PMID: 22704610
9. CTSH overexpression in a subset hepatoma may be thyroid hormone receptor dependent and suggests that this overexpression has an important role in hepatoma progression. PMID: 21217776
10. These data indicate that cathepsins B, L and S may act as cell-death mediators in in monocytic cells infected with ICP4 and Us3 deletion mutant herpes simplex virus type 1. PMID: 20881085
11. involvement in processing of hydrophobic surfactant-associated protein C in type II pneumocytes PMID: 12034564
12. Cathepsin H could contribute to the transformation of LDL to an atherogenic moiety; the process might involve a self-sustaining amplifying circle. PMID: 12615673
13. kinetic data on substrates hydrolysis and enzyme inhibition show the role of the mini-chain as a framework for transition state stabilization of free alpha-amino groups of substrates and as a structural barrier for endopeptidase-like substrate cleavage. PMID: 14515996
14. AKR1B1 and CTSH may be good markers for prediction of sensitivity to certain drugs PMID: 14662023
15. cathepsin H is involved in maturation of the biologically active surfactant associated protein B PMID: 14766755
16. cathepsin H has a role in progression of colorectal cancer that is distinct from that of cathepsins B and L PMID: 15646835
17. A general defect in napsin A or cathepsin H expression or activity was not the specific cause for abnormal surfactant accumulation in juvenile pulmonary alveolar proteinosis PMID: 18216060
18. In contrast to cathepsin S, cathepsin H values did not correlate with markers of inflammation, indicating a specific role for cathepsin H in the pleural host response. PMID: 19404922
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亞細(xì)胞定位：

Lysosome.
蛋白家族：

Peptidase C1 family
數(shù)據(jù)庫(kù)鏈接：

HGNC: 2535

OMIM: 116820

KEGG: hsa:1512

STRING: 9606.ENSP00000220166

UniGene: Hs.148641

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