CTDSP1 Antibody
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中文名稱：CTDSP1兔多克隆抗體
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貨號：CSB-PA131500
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規格：￥2024
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圖片：
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Western blot analysis of extracts from HUVEC cells and HeLa cells, using CTDSP1 antibody. -
Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue, using CTDSP1 antibody.
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) CTDSP1 Polyclonal antibody
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Uniprot No.：
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基因名：CTDSP1
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宿主：Rabbit
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反應種屬：Human
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免疫原：Synthesized peptide derived from N-terminal of Human CTDSP1.
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免疫原種屬：Homo sapiens (Human)
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克隆類型：Polyclonal
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純化方式：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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濃度：It differs from different batches. Please contact us to confirm it.
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產品提供形式：Liquid
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應用范圍：ELISA,WB,IHC
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推薦稀釋比：
Application Recommended Dilution WB 1:500-1:3000 IHC 1:50-1:100 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
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靶點詳情
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功能：Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residue repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells.
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基因功能參考文獻：
- SCP1 is the phosphatase that counterregulates the MAPK-mediated phosphorylation of Ser(68)-Twist1. PMID: 26975371
- SCP1 regulates c-Myc stability and functions through dephosphorylating c-Myc Serine-62. PMID: 25893300
- hSCP1 may be an beta-O-linked N-acetylglucosamine modified protein in vivo. PMID: 25081999
- CTDSP1 activity stabilizes REST in stem cells and ERK-dependent phosphorylation combined with Pin1 activity promotes REST degradation in neural progenitors. PMID: 25197063
- SCP1 phosphatase substrate specificity: CdcA3 could be an enzymatic substrate for SCP1. PMID: 24769477
- Captured the phosphoryl-aspartate intermediate in the crystal structure of a Scp1D206A mutant soaked with para-nitrophenyl phosphate (pNPP), providing strong evidence for the proposed mechanism. PMID: 20222012
- Polymorphisms vary significantly between races; Not associated with TB susceptibility in Caucasians. PMID: 11950066
- SCP1 may play a role in the regulation of gene expression, possibly by controlling the transition from initiation/capping to processive transcript elongation PMID: 12721286
- results show that REST/NRSF recruits SCPs to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells PMID: 15681389
- SCP1 acts as a phosphatase for regulatory phosphorylations in the linker region of Smad1 and Smad2. PMID: 17085434
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亞細胞定位：Nucleus. Note=Colocalizes with RNA polymerase II.
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組織特異性：Expression is restricted to non-neuronal tissues. Highest expression in skeletal muscle, spleen, lung and placenta.
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數據庫鏈接：
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