CRISP3 Antibody
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中文名稱：CRISP3兔多克隆抗體
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貨號：CSB-PA795553
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規格：￥1100
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圖片：
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The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA795553(CRISP3 Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: ×200) -
The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using CSB-PA795553(CRISP3 Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: ×200)
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其他：
產品詳情
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Uniprot No.：
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基因名：CRISP3
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別名：Aeg 2 antibody; Aeg2 antibody; CRIS3_HUMAN antibody; CRISP 3 antibody; CRISP-3 antibody; Crisp3 antibody; CRS 3 antibody; CRS3 antibody; Cysteine rich secretory protein 3 antibody; Cysteine-rich secretory protein 3 antibody; dJ442L6.3 antibody; MGC126588 antibody; OTTHUMP00000016590 antibody; OTTHUMP00000039911 antibody; SGP 28 antibody; SGP28 antibody; SGP28 protein antibody; Specific granule protein (28 kDa) antibody; Specific granule protein of 28 kDa antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Fusion protein of Human CRISP3
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
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抗體亞型：IgG
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純化方式：Antigen affinity purification
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
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產品提供形式：Liquid
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應用范圍：ELISA,IHC
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推薦稀釋比：
Application Recommended Dilution ELISA 1:2000-1:10000 IHC 1:100-1:300 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
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靶點詳情
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基因功能參考文獻：
- results suggest that overexpression of CRISP-3 in prostate tumor may maintain higher PSA expression and lower ANXA1 expression PMID: 26369530
- These data suggest roles for epithelial and neutrophil-derived CRISP3 in postmenstrual endometrial repair and regeneration PMID: 25715794
- up-regulation of the mRNA encoding cysteine-rich secretory protein 3 (CRISP3), a glycoprotein with unknown function that is secreted from multiple exocrine glands, was correlated with HCV resistance. PMID: 24978310
- Strong CRISP3 expression is associated with unfavorable tumor phenotype and early recurrence in prostate cancers PMID: 23196798
- terminal beta-strands of PSP94 contact the first alpha-helix and the hinge region of CRISP-3 PMID: 23375721
- MSMB and CRISP3 were widely distributed in ovaries and in ovarian tumors; the expression of MSMB fits well with a tumor-suppressor function in ovarian carcinogenesis. PMID: 22993349
- up-regulation of CRISP3 is associated with prostate carcinomas with the TMPRSS2-ERG fusion gene. PMID: 21814574
- We found no correlation between CRISP3 expression and biochemical recurrence. PMID: 21240253
- Expression levels of AR and CRISP3 were not affected by short-term ADT but were high in castration-resistant prostate cancer (CRPC) and metastases. PMID: 20680031
- Either PSP94 or CRISP-3 alone can induce growth inhibition in prostate cancer cells in a cell line specific manner. PMID: 20676114
- Additional transcription changes likely associated with Th2-like eosinophilic inflammation were prominent and included decreased CRISP2&3. PMID: 20625511
- Complex binding of CRISP proteins by A1BG and other proteins may interfere with the detection and function of these proteins. PMID: 20116414
- The presence of CRISP-3 in peroxidase-negative granules of neutrophils, in granules of eosinophils, and in exocrine secretions indicates a role in the innate host defense. PMID: 12223513
- in situ hybridization experiments indicated that CRISP-3 mRNA is epithelial-specific and is up-regulated in prostate adenocarcinoma compared with benign prostate tissue; a potential biomarker for prostate cancer PMID: 12433721
- high levels of CRISP-3 in acinar cells dedifferentiating into small proliferating ductal cells in chronic pancreatitis suggests a role of this molecule in the pathophysiology of chronic pancreatitis PMID: 12647793
- alpha-1-B glycoprotein-CRISP-3 complex displays a similar function in protecting the circulation from a potentially harmful effect of free CRISP-3 PMID: 15461460
- Human CRISP-3 is a quantitatively minor seminal plasma protein not associated with prostasomes. CRISP-3 was found in secretory epithelium throughout the male genital tract, with particularly high expression in cauda epididymis and ampulla vas deferens. PMID: 15867000
- Structural similarity with an MSP-binding protein from blood plasma suggests that CRISP-3 binds MSP through its aminoterminal SCP-domain. PMID: 15950934
- Strong immunostaining for CRISP-3 is common in high-grade prostatic-intraepithelial-neoplasia and preserved in prostatic csncer. PMID: 16388501
- Predictor of recurrence after radical prostatectomy for localized prostate cancer. PMID: 17634540
- CRISP-3 pathology occurred in acini remote from lymphocyte foci and may represent some systemic effect in Sjogren Syndrome. PMID: 17665393
- A tentative structure for the hMSP-CRISP-3 complex using the known crystal structure of triflin as a model of CRISP-3 was presented. PMID: 19026612
- Results suggest that absence of a local reduction in expression of CRISP-3 in decidualized endometrium of women with EP may be due to reduced exposure to hCG due to the ectopic location of the trophoblast. PMID: 19282327
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亞細胞定位：Secreted. Note=In neutrophils, localized in specific granules.
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蛋白家族：CRISP family
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組織特異性：Salivary gland, pancreas and prostate > epididymis, ovary, thymus and colon.
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數據庫鏈接：
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