CRCP Antibody

中文名稱：

CRCP兔多克隆抗體
貨號：

CSB-PA005945LA01HU
規格：

￥440
圖片：
Immunohistochemistry of paraffin-embedded human ovarian cancer using CSB-PA005945LA01HU at dilution of 1:100

Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA005945LA01HU at dilution of 1:100

Immunofluorescent analysis of MCF-7 cells using CSB-PA005945LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
其他：

產品詳情
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靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) CRCP Polyclonal antibody
Uniprot No.：

O75575
基因名：

CRCP
別名：

Calcitonin gene related peptide receptor component antibody; Calcitonin gene related peptide receptor component protein antibody; Calcitonin gene-related peptide-receptor component protein antibody; CGRP receptor component protein antibody; CGRP-RCP antibody; CGRP-receptor component protein antibody; CGRPRCP antibody; CRCP antibody; DNA-directed RNA polymerase III subunit RPC9 antibody; HsC17 antibody; RCP antibody; RCP9 antibody; RNA polymerase III subunit C9 antibody; RPC9_HUMAN antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human DNA-directed RNA polymerase III subunit RPC9 protein (1-115AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，CRCP Antibody (CSB-PA005945LA01HU)，的標記方式是Non-conjugated。對于CRCP Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA005945LB01HU	CRCP Antibody, HRP conjugated	ELISA
FITC	CSB-PA005945LC01HU	CRCP Antibody, FITC conjugated
Biotin	CSB-PA005945LD01HU	CRCP Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, IHC, IF

推薦稀釋比：

Application	Recommended Dilution
IHC	1:20-1:200
IF	1:50-1:200

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts induce type I interferon and NF- Kappa-B through the RIG-I pathway.; Accessory protein for the calcitonin gene-related peptide (CGRP) receptor. It modulates CGRP responsiveness in a variety of tissues.
基因功能參考文獻：
1. data reinforce and clarify our understanding of CGRP receptor localization, and provide evidence that antagonist antibodies bind to target sites in the trigeminovascular system of primates that are involved in the pathology of migraine PMID: 27155150
2. CGRP family of receptors displays both ligand- and RAMP-dependent signaling bias among the Galphas, Galphai, and Galphaq/11 pathways. PMID: 27566546
3. In this review, the influence of the CGRP family peptides in reproduction and pregnancy is explored and discussed. PMID: 25015815
4. This study demonstrates the detailed expression of CGRP and its receptor components within spinal trigeminal nucleus in the brainstem and in the spinal cord at C1-level PMID: 22074408
5. The extracellular protein domains corresponding to residues 23-133 of calcitonin receptor-like receptor and residues 26-117 of receptor activity-modifying protein 1 (RAMP1) are shown to be sufficient for formation of a stable, folded monodisperse complex. PMID: 20099900
6. Expression of CGRP-RCP was detected in CD34+ cells and also in some mature granulocyte samples, providing evidence that CGRP-RCP may be regulated independently of RAMP1 and CRLR in hematopoietic cells. PMID: 11937264
7. human CGRP-RCP is the genuine orthologue of C17. CGRP-RCP was found to functionally replace C17 in Deltarpc17 yeast cells; CGRP-RCP was identified in a purified human Pol III preparation. PMID: 12482973
8. inhibition of ACE seems to augment CGRP catabolism. PMID: 16406141
9. Increased mRNA expression CGRP-RCP in gravid myometrium supports the possibility of involvement of CGRP in the control of myometrial contractility. PMID: 17853344
10. A peptide mimetic demonstrates that 12 residues of family B member CGRP receptor proximal C-terminus are required for this receptor's expression and localization at the cell membrane. PMID: 18636754
11. analysis of the effects of antagonists to the CGRP receptor PMID: 19053766
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亞細胞定位：

Nucleus. Cell membrane; Peripheral membrane protein; Cytoplasmic side.
蛋白家族：

Eukaryotic RPC9 RNA polymerase subunit family
組織特異性：

Ubiquitous. Most prevalent in testis.
數據庫鏈接：

HGNC: 17888

OMIM: 606121

KEGG: hsa:27297

STRING: 9606.ENSP00000378736

UniGene: Hs.300684

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