CORO1A Antibody
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中文名稱：CORO1A兔多克隆抗體
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貨號：CSB-PA259764
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規格：￥2024
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圖片：
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Western blot analysis of extracts from Jurkat cells, using CORO1A antibody.
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) CORO1A Polyclonal antibody
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Uniprot No.：
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基因名：CORO1A
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宿主：Rabbit
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反應種屬：Human
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免疫原：Synthesized peptide derived from Internal of Human CORO1A.
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免疫原種屬：Homo sapiens (Human)
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克隆類型：Polyclonal
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純化方式：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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濃度：It differs from different batches. Please contact us to confirm it.
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產品提供形式：Liquid
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應用范圍：ELISA,WB
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推薦稀釋比：
Application Recommended Dilution WB 1:500-1:3000 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
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靶點詳情
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功能：May be a crucial component of the cytoskeleton of highly motile cells, functioning both in the invagination of large pieces of plasma membrane, as well as in forming protrusions of the plasma membrane involved in cell locomotion. In mycobacteria-infected cells, its retention on the phagosomal membrane prevents fusion between phagosomes and lysosomes.
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基因功能參考文獻：
- Levels of p21 and p27 were decreased in TACO or pAKT overexpressing HCC due to SKP2 upregulation. PMID: 27779207
- Data suggest that CORO1A plays key role in neuronal signaling; roles of CORO1A in multiple signaling pathways suggest that CORO1A may influence cross talk between key pathways. [REVIEW] PMID: 28215292
- It has been shown that WDR26 promotes Rac1 membrane translocation following a Coro1A-like and Coro1A-dependent mechanism. PMID: 27835684
- Our studies demonstrate the importance of intact CORO1A C-terminal domains in thymic egress and T-cell survival, as well as in defense against viral pathogens. PMID: 26476480
- These findings suggest that coronin 1A modulates endothelial cell apoptosis by regulating p38beta expression and activation. PMID: 25936522
- Together, these findings both in Jurkat T cells as well as in primary T cells indicate a regulatory role of Coro1A on PKCtheta; recruitment and function downstream of the TCR leading to NF-kappaB transactivation. PMID: 25889880
- mutatiions result in abnormal T-cells, severe combined immunodeficiency of an epidermodysplasia verruciformis-human papilloma virus mucocutaneous syndrome with B and NK defects and shortened telomeres PMID: 25073507
- Coronin 1 trimerization is essential to promote mycobacterial survival within macrophages PMID: 25217836
- Nox4-mediated redox regulation of PTP1B serves as a modulator, in part through coronin-1C, of the growth and migration of glioblastoma cells. PMID: 24239742
- Absence of coronin 1A is associated with severe combined immunodeficiency in humans, hypomorphic mutations lead to a profound defect in naive T cells, expansion of oligoclonal memory T cells, and susceptibility to Epstein Barr B lymphoproliferation. PMID: 25269405
- Results indicate that Coronin1 proteins are at the center of a regulatory hub that coordinates Rac1 activation, effector exchange, and the F-actin organization state during cell signaling. PMID: 24980436
- show a critical role for F-actin deconstruction in cytotoxic function and immunological secretion and identify Coro1A as its mediator PMID: 24760828
- These results demonstrate that coronin-1a is a novel antibody target for clinically isolated syndrome and multiple sclerosis. PMID: 23745754
- Our findings define a new clinical entity of a primary immunodeficiency with increased susceptibility to EBV-induced lymphoproliferation in patients associated with hypomorphic Coronin-1A mutation. PMID: 23522482
- PU.1 and CEBPA are direct transcriptional regulators of CORO1A in acute promyelocytic leukemia and acute myeloid leukemia. PMID: 23252456
- Constitutive turnover of phosphorylation at Thr-412 of p57/coronin-1 regulates its interaction with actin. PMID: 23100250
- Coronin 1A promotes a cytoskeletal-based feedback loop that facilitates Rac1 translocation and activation PMID: 21873980
- Instead of regulating the F-actin cytoskeleton, coronin 1 functions in balancing pro- and antiapoptotic signals by regulating divalent calcium ion fluxes and calcineurin activation downstream of the T cell receptor. PMID: 21339362
- These results demonstrate that p57/coronin-1 forms homodimers, that the association is mediated by the leucine zipper structure in the C-terminal region, and that it plays a role in the cross-linking of F-actin in the cell. PMID: 15601263
- The leukocyte plasma membrane associates with the actin cytoskeleton through coronin-1. PMID: 15800061
- downregulation of TACO gene transcription restricts entry/survival of mycobacteria within macrophages PMID: 16040207
- Our results strongly suggested that there was a new actin-binding region at the C-terminus of p57. PMID: 16467882
- Coronin-1 accumulates at the leading edge of migrating neutrophils and at the nascent phagosome. PMID: 17442961
- phosphorylation of p57/coronin-1 down-regulates its association with actin and modulates the reorganization of actin-containing cytoskeleton PMID: 18693254
- Findings establish a function for coronin 1A in T cell egress, identify a surface of coronin involved in Arp2/3 regulation. PMID: 18836449
- Circulating neutrophils from CF patients had more coronin-1 expression, associated with a lower apoptosis rate PMID: 19454722
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相關疾病：Immunodeficiency 8 (IMD8)
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亞細胞定位：Cytoplasm, cytoskeleton. Cytoplasm, cell cortex. Cytoplasmic vesicle, phagosome membrane.
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蛋白家族：WD repeat coronin family
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組織特異性：Expressed in brain, thymus, spleen, bone marrow and lymph node. Low in lung and gut.
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數據庫鏈接：
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