COL9A1 Antibody
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中文名稱：COL9A1兔多克隆抗體
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貨號(hào)：CSB-PA007097
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規(guī)格：￥1090
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圖片：
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Western Blot analysis of HepG2 cells using COL9A1 Polyclonal Antibody
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其他：
產(chǎn)品詳情
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Uniprot No.：
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基因名：
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別名：COL9A1Collagen alpha-1(IX) chain antibody
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宿主：Rabbit
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反應(yīng)種屬：Human,Mouse
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免疫原：Synthesized peptide derived from the Internal region of Human COL9A1.
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免疫原種屬：Homo sapiens (Human)
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標(biāo)記方式：Non-conjugated
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抗體亞型：IgG
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純化方式：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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產(chǎn)品提供形式：Liquid
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應(yīng)用范圍：WB, IHC, ELISA
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推薦稀釋比：
Application Recommended Dilution WB 1:500-1:2000 IHC 1:100-1:300 ELISA 1:5000 -
Protocols：
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儲(chǔ)存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產(chǎn)品評(píng)價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情
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功能：Structural component of hyaline cartilage and vitreous of the eye.
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基因功能參考文獻(xiàn)：
- the COL9A1 rs35470562 variant may contribute to congenital talipes equinovarus susceptibility in the Chinese population examined. PMID: 27819742
- We observed a significant association between rs6910140 of COL9A1 and KBD, suggesting a role of COL9A1 in the development of KBD. PMID: 25774918
- The study demonstrated that hypermethylation is associated with down-regulation of COL9A1 expression in osteoarthritic (OA) cartilage and highlights the pivotal role of epigenetics in OA. PMID: 25048791
- The NC2 domain of type IX collagen determines the chain composition but also the chain register of the triple helix. PMID: 23132862
- Type IX collagen interacts with fibronectin providing an important molecular bridge in articular cartilage PMID: 21768108
- A second, novel mutation was identified in COL9A1, causing autosomal recessive Stickler syndrome together with the previously described nucleotide change in two separate families. PMID: 21421862
- COL9A1 protein is highly expressed in patients with idiopathic congenital talipes equinovarus (ICTEV) and rs1135056, which is located in the coding region of COL9A1 gene, may be associated with the pathogenesis of ICTEV. PMID: 21672422
- NC2 domain of collagen IX provides chain selection and heterotrimerization PMID: 20507993
- This study extends the range of gene-mutations that can cause multiple epiphyseal dysplasia-related myopathy. PMID: 20358595
- Data show that the proximal-promoter region of the human COL9A1 gene can drive expression of a reporter gene in chondrocytic RCS cells, but not in nonchondrocytic cell lines. PMID: 12399468
- the amino-terminal NC4 domain of human collagen IX interacts with glycosaminoglycans and cartilage oligomeric matrix protein PMID: 15047691
- COMP, type IX collagen and MATN3 play important roles in matrix assembly PMID: 15694129
- A search of the microRNA database revealed a highly conserved target sequence for miR-9 immediately preceding the overlapping polyadenylation signals in the novel 3' UTR of COL9A1, suggesting its role in posttranscriptional regulation of COL9A1. PMID: 16718610
- COL9A1 is the fourth identified gene that can cause Stickler syndrome. PMID: 16909383
- analysis of the crystal structure of the N-terminal NC4 domain of collagen IX PMID: 17553797
- the matrilin-3 A-domain appears to bind exclusively to the COL3 domain of type IX collagen and this binding is abolished in the presence of a disease causing mutation in type IX collagen PMID: 17881354
- mutation causes multiple epiphyseal dysplasia; genetic heterogeneity PMID: 11565064
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相關(guān)疾病：Multiple epiphyseal dysplasia 6 (EDM6); Stickler syndrome 4 (STL4)
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亞細(xì)胞定位：Secreted, extracellular space, extracellular matrix.
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蛋白家族：Fibril-associated collagens with interrupted helices (FACIT) family
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數(shù)據(jù)庫鏈接：
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