COL12A1 Antibody
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中文名稱：COL12A1兔多克隆抗體
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貨號：CSB-PA669302
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規(guī)格：￥1090
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圖片：
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Immunohistochemical analysis of paraffin-embedded human-muscle, antibody was diluted at 1:200
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其他：
產(chǎn)品詳情
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Uniprot No.：
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基因名：COL12A1
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別名：COL12A1 antibody; COL12A1LCollagen alpha-1(XII) chain antibody
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宿主：Rabbit
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反應(yīng)種屬：Human
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免疫原：Synthetic peptide from Human protein at AA range: 1268-1341
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
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純化方式：The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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產(chǎn)品提供形式：Liquid
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應(yīng)用范圍：IHC,ELISA
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推薦稀釋比：
Application Recommended Dilution IHC IHC-p:1:50-1:300 ELISA 1:5000-1:20000 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產(chǎn)品評價
相關(guān)產(chǎn)品
靶點詳情
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功能：Type XII collagen interacts with type I collagen-containing fibrils, the COL1 domain could be associated with the surface of the fibrils, and the COL2 and NC3 domains may be localized in the perifibrillar matrix.
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基因功能參考文獻：
- The study indicates that the spectrum of causative genes in extracellular matrix-related myopathies be extended to include COL12A1. PMID: 24334769
- collagen alpha-1 (XII) chain was expressed at dramatically higher (~10-fold) levels in breast PMID: 24262153
- Type XII collagen is overexpressed in permanent human and mouse corneal scars and could represent a new target to treat corneal scarring. PMID: 22969073
- In addition to binding collagen I, COMP binds to collagens XII and XIV via their C-terminal collagenous domains. PMID: 22573329
- COL12A1 is associated with anterior cruciate ligament ruptures among females PMID: 19443461
- this study identifies COL12A1 as the likely gene candidate within the recurrent 6q13 breakpoint and provides an alternative approach for detecting 6q13 anomalies in nondividing cells of chondromyxoid fibroma. PMID: 19648885
- induction of expression by sheare stress is associated with atherogenesis PMID: 12890494
- Results suggest that collagens XII and XIV might serve different functions during human embryonic development although their structures are highly similar. PMID: 15609093
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相關(guān)疾病：Ullrich congenital muscular dystrophy 2 (UCMD2); Bethlem myopathy 2 (BTHLM2)
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亞細胞定位：Secreted, extracellular space, extracellular matrix.
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蛋白家族：Fibril-associated collagens with interrupted helices (FACIT) family
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組織特異性：Found in collagen I-containing tissues: both isoform 1 and isoform 2 appear in amnion, chorion, skeletal muscle, small intestine, and in cell culture of dermal fibroblasts, keratinocytes and endothelial cells. Only isoform 2 is found in lung, placenta, ki
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