CNOT7 Antibody
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中文名稱：CNOT7兔多克隆抗體
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貨號：CSB-PA446150
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規格：￥2024
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圖片：
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Western blot analysis of extracts from HUVEC cells and HeLa cells, using CNOT7 antibody.
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) CNOT7 Polyclonal antibody
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Uniprot No.：
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基因名：CNOT7
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宿主：Rabbit
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反應種屬：Human,Mouse
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免疫原：Synthesized peptide derived from N-terminal of Human CNOT7.
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免疫原種屬：Homo sapiens (Human)
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克隆類型：Polyclonal
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純化方式：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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濃度：It differs from different batches. Please contact us to confirm it.
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產品提供形式：Liquid
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應用范圍：ELISA,WB
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推薦稀釋比：
Application Recommended Dilution WB 1:500-1:3000 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Its function seems to be partially redundant with that of CNOT8. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex seems also to act as translational repressor during translational initiation. Additional complex functions may be a consequence of its influence on mRNA expression. Associates with members of the BTG family such as TOB1 and BTG2 and is required for their anti-proliferative activity.
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基因功能參考文獻：
- Findings suggest a preferential involvement of CNOT7 variant 2 (CNOT7v2) in nuclear processes, such as arginine methylation and alternative splicing, rather than mRNA turnover PMID: 28591869
- MEX3C associates with the cytoplasmic deadenylation complexes and ubiquitinates CNOT7. PMID: 26471122
- CNOT7/hCAF1 is involved in ICAM-1 and IL-8 regulation by TTP in HPMEC. PMID: 25038453
- CNOT7 is an antimicrobial protein and a regulator of the innate immune response. PMID: 23386060
- The anti-proliferative activity of BTG/TOB proteins is mediated via the Caf1a (CNOT7) and Caf1b (CNOT8) deadenylase subunits of the Ccr4-not complex. PMID: 23236473
- CNOT7 is not the target tumor suppressor gene in the 8p22-23.1 colorectal cancer suppressor region. PMID: 12845644
- CAF1 is a new regulator of PRMT1-dependent arginine methylation. PMID: 17264152
- Data show that Ccr4-Not function in RNA splicing and nuclear export, and that CNOT7 binds strongly with CNOT6. PMID: 19558367
- Data show that efficient cell proliferation requires both CNOT7 and CNOT8, although combined knockdown of both subunits further reduces cell proliferation indicating partial redundancy between these proteins. PMID: 19605561
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亞細胞定位：Nucleus. Cytoplasm, P-body.
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蛋白家族：CAF1 family
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數據庫鏈接：
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