CNOT4 Antibody

說明書

產品詳情

Uniprot No.：

O95628
基因名：

CNOT4
別名：

CCR4 NOT transcription complex subunit 4 antibody; CCR4-associated factor 4 antibody; CCR4-NOT transcription complex subunit 4 antibody; CLONE243 antibody; CNOT 4 antibody; Cnot4 antibody; CNOT4_HUMAN antibody; E3 ubiquitin-protein ligase CNOT4 antibody; NOT 4 antibody; NOT4 (negative regulator of transcription 4 yeast) homolog antibody; NOT4 antibody; NOT4H antibody; Potential transcriptional repressor NOT4Hp antibody
宿主：

Rabbit
反應種屬：

Human,Mouse,Rat
免疫原：

Synthesized peptide derived from the Internal region of Human CNOT4.
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
產品提供形式：

Liquid
應用范圍：

WB, IHC, ELISA

推薦稀釋比：

Protocols：

Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Has E3 ubiquitin ligase activity, promoting ubiquitination and degradation of target proteins. Involved in activation of the JAK/STAT pathway. Catalyzes ubiquitination of methylated RBM15. Plays a role in quality control of translation of mitochondrial outer membrane-localized mRNA. As part of the PINK1-regulated signaling, upon mitochondria damage, ubiquitinates ABCE1 and thereby recruits autophagy receptors to the mitochondrial outer membrane to initiate mitophagy.
基因功能參考文獻：
1. These results indicate that CNOT4 is a ubiquitin ligase of influenza A virus nucleoprotein, and ubiquitination of the nucleoprotein plays a positive role in viral RNA replication. PMID: 28536288
2. CNOT4 controls the degradation of chromatin-unbound PAF1 via the 26S proteasome. PMID: 25933433
3. Single nucleotide polymorphism in CNOT4 gene is associated with osteosarcoma susceptibility. PMID: 25663449
4. Data show that Not4/CNOT4 is a novel positive regulator of the JAK/STAT pathway in Drosophila and in humans. PMID: 22159038
5. Data show that binding of the CNOT4 RING finger to the ubiquitin-conjugating enzyme (E2) UbcH5B is highly selective PMID: 15001359
6. Data show that Ccr4-Not function in RNA splicing and nuclear export, and that CNOT4 binds CNOT1 in yeast two-hybrid assays. PMID: 19558367
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亞細胞定位：

Cytoplasm. Nucleus.
數據庫鏈接：

HGNC: 7880

OMIM: 604911

KEGG: hsa:4850

STRING: 9606.ENSP00000445508

UniGene: Hs.490224

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