CLCN4 Antibody
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中文名稱：CLCN4兔多克隆抗體
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貨號：CSB-PA968321
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規格：￥2024
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圖片：
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Western blot analysis of extracts from MCF-7 cells, using CLCN4 antibody. -
Immunofluorescence analysis of HUVEC cells, using CLCN4 antibody.
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) CLCN4 Polyclonal antibody
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Uniprot No.：
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基因名：CLCN4
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宿主：Rabbit
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反應種屬：Human,Mouse,Rat
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免疫原：Synthesized peptide derived from internal of Human CLCN4.
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免疫原種屬：Homo sapiens (Human)
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克隆類型：Polyclonal
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純化方式：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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濃度：It differs from different batches. Please contact us to confirm it.
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產品提供形式：Liquid
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應用范圍：ELISA,WB,IHC,IF
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推薦稀釋比：
Application Recommended Dilution WB 1:500-1:3000 IHC 1:50-1:200 IF 1:100-1:200 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Strongly outwardly rectifying, electrogenic H(+)/Cl(-)exchanger which mediates the exchange of chloride ions against protons. The CLC channel family contains both chloride channels and proton-coupled anion transporters that exchange chloride or another anion for protons. The presence of conserved gating glutamate residues is typical for family members that function as antiporters.
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基因功能參考文獻：
- This study performed whole exome sequencing demonistrated that the true de novo variants represent mutations in genes (KCNH5, CLCN4, and ARHGEF15) not previously associated with epilepsies in humans. PMID: 23647072
- the voltage dependence of uncoupled ClC-4 by protons and anions PMID: 21354396
- CLCN4 is a novel driver of colon cancer progression. PMID: 20087350
- ClC-4 is an intracellular chloride channel that stimulates copper incorporation into ceruloplasmin, probably by improving the efficiency of the ATP7B copper pump. PMID: 15057754
- coupled Cl-/H+ transport of ClC-4 and ClC-5 is of significant magnitude in vivo PMID: 16034421
- crystal structure: CLIC4 appears to be able to form a redox-regulated ion channel in the absence of any partner proteins PMID: 16176272
- A stretch of amino acids, residues 14-63, at the N-terminus constitutes a novel motif both necessary and sufficient for targeting hClC-4 and other membrane proteins to the endoplasmic reticulum. PMID: 17023393
- The proposed mechanism results in anion-dependent conversion of ClC-type exchanger into an anion channel with typical attributes of ClC anion channels. PMID: 19364886
- Vesicle acidification, exocytosis, endocytosis, and secretory pathway. PMID: 10564087
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相關疾病：Mental retardation, X-linked 49 (MRX49)
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亞細胞定位：Early endosome membrane; Multi-pass membrane protein. Late endosome membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein. Recycling endosome membrane; Multi-pass membrane protein.
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蛋白家族：Chloride channel (TC 2.A.49) family, ClC-4/CLCN4 subfamily
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組織特異性：Abundant in skeletal muscle and also detectable in brain and heart.
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數據庫鏈接：
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