CIITA Antibody
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中文名稱：CIITA兔多克隆抗體
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貨號：CSB-PA010532
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規格：￥1090
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其他：
產品詳情
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Uniprot No.：
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基因名：
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別名：C2TA antibody; C2TA_HUMAN antibody; CIITA antibody; CIITA IV antibody; Class II major histocompatibility complex transactivator antibody; Class II transactivator antibody; MHC class II transactivator antibody; MHC class II transactivator type III antibody; MHC2TA antibody; NLR family acid domain containing antibody; NLRA antibody; Nucleotide binding oligomerization domain leucine rich repeat and acid domain containing antibody
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宿主：Rabbit
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反應種屬：Human,Mouse,Rat
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免疫原：Synthesized peptide derived from the Internal region of Human CIITA.
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
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抗體亞型：IgG
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純化方式：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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產品提供形式：Liquid
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應用范圍：WB, ELISA
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推薦稀釋比：
Application Recommended Dilution WB 1:500-1:2000 ELISA 1:10000 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Essential for transcriptional activity of the HLA class II promoter; activation is via the proximal promoter. No DNA binding of in vitro translated CIITA was detected. May act in a coactivator-like fashion through protein-protein interactions by contacting factors binding to the proximal MHC class II promoter, to elements of the transcription machinery, or both. Alternatively it may activate HLA class II transcription by modifying proteins that bind to the MHC class II promoter. Also mediates enhanced MHC class I transcription; the promoter element requirements for CIITA-mediated transcription are distinct from those of constitutive MHC class I transcription, and CIITA can functionally replace TAF1 at these genes. Activates CD74 transcription. Exhibits intrinsic GTP-stimulated acetyltransferase activity. Exhibits serine/threonine protein kinase activity: can phosphorylate the TFIID component TAF7, the RAP74 subunit of the general transcription factor TFIIF, histone H2B at 'Ser-37' and other histones (in vitro). Has antiviral activity against Ebola virus and coronaviruses, including SARS-CoV-2. Induces resistance by up-regulation of the p41 isoform of CD74, which blocks cathepsin-mediated cleavage of viral glycoproteins, thereby preventing viral fusion.
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基因功能參考文獻：
- CIITA expression is higher when carried by FP single recombinants than when combined with FPgp or FPenv constructs and can induce HLA-DR cell surface expression. However, in-vivo experiments did not show any significant increase in the humoral response. As CIITA already proved to elicit immunogenicity by improving antigen presentation, further in-vivo experiments should be performed to increase the immune responses PMID: 29385169
- Therefore, our data identify HIC1 as a novel factor involved in B cell differentiation acting as an epigenetic repressor of CIITA transcription. PMID: 27720955
- Decreasing CIITA expression in allogeneic MSCs abolished MHC II induction during myogenic differentiation and prevented immunorejection of these cells from the infarcted myocardium, which enhanced beneficial functional effects of MSC implantation on myocardial repair. PMID: 27221978
- Brazilian Amerindian ancestry compared to Asian, European, and African Genomes.SNPs within or proximal to CIITA (rs6498115), SMC6 (rs1834619), and KLHL29 (rs2288697) were most differentiated in the Amerindian-specific branch. SNPs in ADAMTS9 (rs7631391), DOCK2 (rs77594147), SLC28A1 (rs28649017), ARHGAP5 (rs7151991), and CIITA (rs45601437) in the Asian comparison. PMID: 28100790
- CLPTM1L and TERT have been implicated in cancers, and CIITA is considered as the "master control factor" for the expression of NPC-associated MHC class II genes. These suggested that both SNPs might be functional. Altogether, our findings expand our understanding of the genetic contribution to NPC risk and provide novel biological insights into NPC pathogenesis. PMID: 27436580
- When mouse pDCs and CAL-1 cells were stimulated by GM-CSF, mRNA levels of PU.1, pIII-driven CIITA, total CIITA, MHC class II, and the amount of PU.1 binding to pIII were significantly increased PMID: 27105023
- the MHC2TA -168 A/G polymorphism is not associated with susceptibility to rheumatoid arthritis in Caucasians [meta-analysis] PMID: 26439834
- Observed no association between the MHC2TA or FCRL3 SNPs and rheumatoid arthritis in Mexican patients. PMID: 26350270
- CIITA acts as a general restriction factor against HIV-1 not only in T cells but also in myeloid cells. PMID: 27089879
- CIITA gene alterations are a common mechanism of immune escape through reduction of MHC class II expression in primary mediastinal large B cell lymphoma. PMID: 26549456
- CIITA Isoform III interacts more efficiently with components of the transcription machinery and MHC-II promoter binding proteins. PMID: 26871568
- The dimerization region of Epstein-Barr virus Zta is not required to mediate host CIITA repression. PMID: 26653871
- Thus, CIITA inhibits cytoplasmic and nuclear steps of human T cell lymphotropic virus type 1 Tax-1-mediated NF-kappaB activation. PMID: 26792751
- FOXP1 represents a novel regulator of genes targeted by the class II MHC transactivator CIITA and CD74. PMID: 26500140
- Lys(63) ubiquitinated CIITA is concentrated in the cytoplasm and following activation of ERK1/2, CIITA phosphorylation occurs and Lys=ubiquitinated CIITA translocates to the nucleus. PMID: 26181363
- Genomic alterations underlying immune privilege in malignant lymphomas prominently include structural genomic changes of the CIITA and CD274 loci. (Review) PMID: 26049756
- 19S ATPases have nonproteolytic roles in transcription of CIITApIV genes PMID: 24625964
- The negative expression of CIITA protein was the key reason for the loss of MHC II expression in HL60 cells. PMID: 25815463
- two DNA-binding proteins, which interact with and regulate PRC2 recruitment to CIITA promoter IV, were identified. PMID: 26283540
- mutation results in Mycobacterium avium complex infection PMID: 24789686
- Data indicate that the TC+CC genotypes in the MHC class II transactivator gene (MHC2TA) were significantly associated with increased risk of acute coronary syndromes (ACS) as compared to TT genotype. PMID: 25461408
- We observed that the CIITA polymorphism rs4774 (+1614G/C) in combination with HLA-DRB1*15:01 increased the OR to 2.65 (p = 0.005). Females carrying both the rs4774*C and DRB1*15:01 alleles had an OR of 4.55 (p = 0.02). PMID: 25992516
- our data suggest that adenosine A2b signaling represses CIITA transcription in VSMCs by manipulating the interaction between STAT1 and the epigenetic machinery. PMID: 25765819
- PRC2 may inhibit immune surveillance, and it could be targeted to reactivate CIITA expression in SWI/SNF deficient cancers. PMID: 25862816
- define the CIITA regulome in B cells and establish sequence specificities that predict activity for an essential regulator of the adaptive immune response PMID: 25753668
- our findings support previous data that variability in the CIITA gene affects MS risk, but also that the effect is modulated by MS-associated HLA haplotypes. PMID: 24430172
- Sema3A upregulated CIITA expression. Sema3A receptor expression was enhanced by CIITA, establishing a positive feedback loop. Silencing CIITA expression decreases Sema3A-induced CD4+ T-cell proliferation. PMID: 24673430
- the presentation of HLA-DQbeta enhanced by LANA knockdown did not help LANA-specific CD4+ T cell recognition of PEL cells, and the inhibition of CIITA by LANA is independent of IL-4 or IFN-gamma signaling PMID: 24204280
- genetic polymorphism is associated with endemic pemphigus foliaceus in Brazilian population PMID: 23777927
- One-carbon genetic variants influence epigenetic of MHC2TA and RFC1, thus contributing to phenotypic heterogeneity of systemic lupus erythematosus. PMID: 24333266
- Two SNPs (rs12932187 and rs11074938) and 2 haplotypes (CIITA_BL1_ht2 and CIITA_BL1_ht5) were demonstrated to be associated with nasal polyps. PMID: 23292525
- identification of this novel kinase activity of CIITA further clarifies its role as a functional homolog of TAF1 which may operate during stress and gamma-IFN activated MHC gene transcription PMID: 24036077
- Two novel alternatively spliced variants of human interferon gamma-inducible CIITA, one missing exon 7 (CIITADeltaE7), the other with TAG inserted at exon 4/5 junction (CIITA-TAG), were identified and characterized. PMID: 24055710
- Human transgenic CIITA-DN (dominant negative) pig cells were evaluated for expression of SLA class II with/without activation, and the human CD4(+) T-cell response to cells from CIITA-DN and wild-type pigs was compared. PMID: 23566228
- CIITA -168A-->G promoter single nucleotide polymorphisms are not associated with myasthenia gravis. PMID: 20942939
- These results suggest that CIITA transcription is repressed in germinal centre B Diffuse large B-cell lymphoma cells through epigenetic mechanisms PMID: 23789844
- Data from this study suggest an association between Oral Lichen Planus and two SNPs (rs4774 and rs6498122)in the CIITA gene in a Chinese sample. PMID: 23489895
- MHC2TA 1614 gene polymorphism could be involved in the risk of developing acute coronary syndrome PMID: 23511026
- In multiple sclerosis patients, MHC2TA mRNA levels could be decreased by the active replication of HHV-6; the absence of HHV-6 in serum and the increase of MHC2TA expression could be studied as markers of good clinical response to IFN-beta treatment. PMID: 23009575
- A significant correlation has been found in the genotype distribution for markers in CIITA (rs11074932 and rs3087456) and the development of type 1 diabetes in the Swedish cohort. PMID: 23052709
- Polymorphisms in the inflammatory genes CIITA, CLEC16A and IFNG influence BMD, bone loss and fracture in elderly women PMID: 23133532
- The genotypes and allele frequencies distribution of CIITA G-944C were different in the Jinuo, Dai and Aini minority populations. Polymorphism was closely associated with HBsAg carriage. PMID: 21215072
- PML is required for efficient IFN-gamma-induced MHC II gene transcription through regulation of the class II transactivator (CIITA) PMID: 23007646
- The present study suggests that the MHC2TA polymorphisms are not involved in the risk of developing restenosis after coronary stent placement PMID: 23021357
- Our results support involvement of CIITA in RA, but imply that this is population dependent and that the aetiological variant is yet to be discovered. PMID: 22513452
- The expressions of CTA and HLA-DR in Jurkat cells remarkably increase after heat shock. PMID: 20078946
- ESAT6 could inhibit the expression of type I and type IV CIITA through different pathways PMID: 21670739
- The silencing of MHC II molecules in highly metastatic breast cancer cells is associated with distinct epigenetic modifications targeted specifically to the chromatin of CIITApIV. PMID: 22563434
- CIITA overexpression can also activate the expression of these genes, indicating that the immunoproteasome genes LMP2 and LMP7 can be activated by both CIITA dependent and CIITA independent pathways PMID: 21989738
- IFN-gamma-induced phosphorylation of STAT-1 and transcription of CIITA were suppressed in Kaposi's sarcoma-associated herpesvirus-inoculated endothelial cells via a mechanism involving SOCS3 (suppressor of cytokine signaling 3). PMID: 22532676
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相關疾病：Bare lymphocyte syndrome 2 (BLS2)
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亞細胞定位：Nucleus. Nucleus, PML body. Note=Recruited to PML body by PML.
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