CIB2 Antibody
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中文名稱：CIB2兔多克隆抗體
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貨號：CSB-PA089401
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規格：￥2024
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圖片：
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Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue, using CIB2 antibody.
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) CIB2 Polyclonal antibody
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Uniprot No.：
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基因名：CIB2
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宿主：Rabbit
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反應種屬：Human,Mouse
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免疫原：Synthesized peptide derived from internal of Human CIB2.
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免疫原種屬：Homo sapiens (Human)
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克隆類型：Polyclonal
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純化方式：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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濃度：It differs from different batches. Please contact us to confirm it.
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產品提供形式：Liquid
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應用范圍：ELISA,IHC
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推薦稀釋比：
Application Recommended Dilution IHC 1:50-1:100 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Calcium-binding protein critical for proper photoreceptor cell maintenance and function. Plays a role in intracellular calcium homeostasis by decreasing ATP-induced calcium release. May be involved in the mechanotransduction process.
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基因功能參考文獻：
- this study identifies CIB1 and CIB2 as host helper factors for HIV-1 replication that are required for optimal receptor-mediated viral entry PMID: 27489023
- results suggest that GJB2 and CIB2 are common cause of hearing loss in different Pakistani ethnicities PMID: 29086887
- High CIB2 expression is associated with ovarian Cancer. PMID: 28729416
- Novel homozygous missense variant c.196C>T and compound heterozygous variants, c.[97C>T];[196C>T], were associated with nonsyndromic deafness. PMID: 26173970
- We identified a novel variant (rs7164338) on chromosome 15q25.1 in the CIB2 associated with lower pulse wave velocity. PMID: 26378684
- CIB2 (Calcium and Integrin Binding Protein 2) Mutation Associated with Non-Syndromic Hearing Loss in a Hispanic Family PMID: 26426422
- Data indicate that that CIB2 localizes to stereocilia and interacts with the USH proteins myosin VIIa and whirlin, suggesting CIB2 is a Ca2+-buffering protein essential for calcium homeostasis in the mechanosensory stereocilia of inner ear hair cells. PMID: 24022220
- Consistent with molecular modeling predictions of calcium binding, CIB2 significantly decreased the ATP-induced calcium responses in heterologous cells, whereas mutations in deafness DFNB48 altered CIB2 effects on calcium responses PMID: 23023331
- CIB2, as binding partners for the integrin alphaIIb subunit, which suggests that they are potentially involved in regulating integrin alphaIIb subunit activation. PMID: 22779914
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相關疾?。?/div>Deafness, autosomal recessive, 48 (DFNB48); Usher syndrome 1J (USH1J)亞細胞定位：Cytoplasm. Cell projection, stereocilium. Photoreceptor inner segment. Cell projection, cilium, photoreceptor outer segment. Cell membrane, sarcolemma.組織特異性：Widely expressed.數據庫鏈接：
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