CHST3 Antibody
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中文名稱：CHST3兔多克隆抗體
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貨號：CSB-PA005409GA01HU
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規格：￥3,900
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其他：
產品詳情
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Uniprot No.：
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基因名：CHST3
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別名：C6ST 1 antibody; C6ST antibody; C6ST-1 antibody; C6ST1 antibody; Carbohydrate (chondroitin 6) sulfotransferase 3 antibody; Carbohydrate sulfotransferase 3 antibody; Chondroitin 6 O sulfotransferase 1 antibody; Chondroitin 6 sulfotransferase antibody; Chondroitin 6-O-sulfotransferase 1 antibody; Chondroitin 6-sulfotransferase antibody; CHST 3 antibody; Chst3 antibody; CHST3_HUMAN antibody; Galactose/N acetylglucosamine/N acetylglucosamine 6 O sulfotransferase 0 antibody; Galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 0 antibody; GST 0 antibody; GST-0 antibody; GST0 antibody
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宿主：Rabbit
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反應種屬：Human,Mouse,Rat
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免疫原：Human CHST3
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免疫原種屬：Homo sapiens (Human)
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抗體亞型：IgG
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純化方式：Antigen Affinity purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
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產品提供形式：Liquid
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應用范圍：ELISA,WB,IHC
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of the N-acetylgalactosamine (GalNAc) residue of chondroitin. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage and is distributed on the surfaces of many cells and extracellular matrices. Catalyzes with a lower efficiency the sulfation of Gal residues of keratan sulfate, another glycosaminoglycan. Can also catalyze the sulfation of the Gal residues in sialyl N-acetyllactosamine (sialyl LacNAc) oligosaccharides. May play a role in the maintenance of naive T-lymphocytes in the spleen.
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基因功能參考文獻：
- We describe three consanguineous Indian families with a distinct form of spondyloepiphyseal dysplasia (SED Omani type). It is an autosomal recessive disorder due to mutation in CHST3 gene. PMID: 27753269
- A novel CHST3 allele associated with spondyloepiphyseal dysplasia and hearing loss has been described in a consanguineous Pakistani pedigree. PMID: 26572954
- Sequencing of CHST3 detected a previously unreported homozygous duplication c.407_426dup (p.Thr143Cysfs*80). The mutation is predicted to lead to frameshift and introduction of a premature stopcodon. PMID: 24300290
- expression of CHST3 mRNA was significantly reduced in the intervertebral disc cells of subjects carrying the A allele of rs4148941 PMID: 24216480
- The results of this study indicated that the critical period for cortical plasticity is regulated by the 4S/6S ratio of CSPGs, which determines the maturation of parvalbumin-expressing interneurons. PMID: 22246436
- Vertebral changes, normal carpal age, lack of facial flattening, and recessive inheritance are characteristic and distinguishes CHST3 deficiency from other disorders with congenital dislocations. PMID: 20830804
- report eight CHST3 mutations in six unrelated individuals who presented at birth with congenital joint dislocations PMID: 18513679
- Sulfation of the galactose residues in the glycosaminoglycan-protein linkage region by recombinant human chondroitin 6-O-sulfotransferase-1. PMID: 18697746
- homozygous missense mutation (T141M) in exon 3 in all three family members with spondyloepiphyseal dysplasia with cardiac involvement PMID: 19320654
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相關疾病：Spondyloepiphyseal dysplasia with congenital joint dislocations (SEDCJD)
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亞細胞定位：Golgi apparatus membrane; Single-pass type II membrane protein.
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蛋白家族：Sulfotransferase 1 family, Gal/GlcNAc/GalNAc subfamily
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組織特異性：Widely expressed in adult tissues. Expressed in heart, placenta, skeletal muscle and pancreas. Also expressed in various immune tissues such as spleen, lymph node, thymus and appendix.
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數據庫鏈接：
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