CEP164 Antibody

中文名稱：

CEP164兔多克隆抗體
貨號：

CSB-PA892491LA01HU
規格：

￥440
圖片：
IHC image of CSB-PA892491LA01HU diluted at 1:600 and staining in paraffin-embedded human pancreatic cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) CEP164 Polyclonal antibody
Uniprot No.：

Q9UPV0
基因名：

CEP164
別名：

AI450905 antibody; BC027092 antibody; CE164_HUMAN antibody; Centrosomal protein 164 antibody; Centrosomal protein 164kDa antibody; Centrosomal protein of 164 kDa antibody; Cep164 antibody; D030051D21 antibody; FLJ54767 antibody; KIAA1052 antibody; MGC38792 antibody; mKIAA1052 antibody; NPHP15 antibody; OTTMUSP00000042044 antibody; RGD1560988 antibody; RGD1561243 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Centrosomal protein of 164 kDa protein (1-112AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，CEP164 Antibody (CSB-PA892491LA01HU)，的標記方式是Non-conjugated。對于CEP164 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA892491LB01HU	CEP164 Antibody, HRP conjugated	ELISA
FITC	CSB-PA892491LC01HU	CEP164 Antibody, FITC conjugated
Biotin	CSB-PA892491LD01HU	CEP164 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, IHC

推薦稀釋比：

Application	Recommended Dilution
IHC	1:500-1:1000

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Plays a role in microtubule organization and/or maintenance for the formation of primary cilia (PC), a microtubule-based structure that protrudes from the surface of epithelial cells. Plays a critical role in G2/M checkpoint and nuclear divisions. A key player in the DNA damage-activated ATR/ATM signaling cascade since it is required for the proper phosphorylation of H2AX, RPA, CHEK2 and CHEK1. Plays a critical role in chromosome segregation, acting as a mediator required for the maintenance of genomic stability through modulation of MDC1, RPA and CHEK1.
基因功能參考文獻：
1. data suggest that CEP164 is not required in the DNA damage response. PMID: 26966185
2. This study reveals a novel role for CEP164 in the pathogenesis of nephronophthisis, in which mutations cause ciliary defects coupled with DNA damage induced replicative stress, cell death, and epithelial-to-mesenchymal transition PMID: 25340510
3. Evidence is provided that TTBK2 effectively phosphorylate Cep164 and Cep97 and inhibits the interaction between Cep164 and its binding partner Dishevelled-3 (an important regulator of ciliogenesis) in a kinase activity-dependent manner. PMID: 25297623
4. data suggest that TTBK2 also acts upstream of Cep164, contributing to the assembly of distal appendages PMID: 24982133
5. Cep164 is targeted to the apical domain of the mother centriole to provide the molecular link between the mother centriole and the membrane biogenesis machinery that initiates cilia formation. PMID: 23253480
6. findings indicate that ARL13B, INPP5E, PDE6D, and CEP164 form a distinct functional network that is involved in JBTS and NPHP but independent of the ones previously defined by NPHP and MKS proteins PMID: 23150559
7. Study identifies by whole-exome resequencing, mutations of MRE11, ZNF423, and CEP164 as causing Nephronophthisis-related ciliopathies. PMID: 22863007
8. Single nucleotide polymorphisms of CCND2, RAD23B, GRP78, CEP164, MDM2, and ALDH2 genes were significantly associated with development and recurrence of hepatocellular carcinoma in Japanese patients with hepatitis C virus. PMID: 22004425
9. These data implicate distal appendages in primary cilia formation and identify Cep164 as an excellent marker for these structures. PMID: 17954613
10. Cep164 is a key player in the DNA damage-activated signaling cascade. PMID: 18283122
11. Results show that Cep164 knockdown compromises the cell survival upon UV damage, and that UV irradiation significantly enhances the interaction between Cep164 and XPA. PMID: 19197159
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相關疾病：

Nephronophthisis 15 (NPHP15)
亞細胞定位：

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Nucleus.
組織特異性：

Expressed in several cell lines.
數據庫鏈接：

HGNC: 29182

OMIM: 614845

KEGG: hsa:22897

STRING: 9606.ENSP00000278935

UniGene: Hs.504009

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