CELF2 Antibody
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中文名稱：CELF2兔多克隆抗體
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貨號：CSB-PA006217GA01HU
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規格：￥3,900
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其他：
產品詳情
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Uniprot No.：
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基因名：CELF2
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別名：Bruno-like protein 3 antibody; BRUNOL3 antibody; Cardiac elav type RNA binding protein antibody; CELF-2 antibody; celf2 antibody; CELF2_HUMAN antibody; CUG BP2 antibody; CUG triplet repeat RNA-binding protein 2 antibody; CUG-BP- and ETR-3-like factor 2 antibody; CUG-BP2 antibody; CUGBP Elav like family member 2 antibody; CUGBP Elav-like family member 2 antibody; CUGBP2 antibody; dJ323N1.1 antibody; elav type RNA binding protein antibody; ELAV-type RNA-binding protein 3 antibody; ETR 3 antibody; ETR-3 antibody; ETR3 antibody; HGNC:2550 antibody; hNAPOR antibody; NAPOR 2 antibody; NAPOR antibody; Neuroblastoma apoptosis-related RNA-binding protein antibody; Neuroplastoma apoptosis related RNA binding protein 3 antibody; RNA binding protein BRUNOL3 antibody; RNA-binding protein BRUNOL-3 antibody
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宿主：Rabbit
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反應種屬：Human,Mouse,Rat
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免疫原：Human CUGBP2
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免疫原種屬：Homo sapiens (Human)
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抗體亞型：IgG
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純化方式：Antigen Affinity Purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
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產品提供形式：Liquid
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應用范圍：ELISA,WB,IHC
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：RNA-binding protein implicated in the regulation of several post-transcriptional events. Involved in pre-mRNA alternative splicing, mRNA translation and stability. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of TNNT2 in embryonic, but not adult, skeletal muscle. Activates TNNT2 exon 5 inclusion by antagonizing the repressive effect of PTB. Acts as both an activator and repressor of a pair of coregulated exons: promotes inclusion of the smooth muscle (SM) exon but exclusion of the non-muscle (NM) exon in actinin pre-mRNAs. Promotes inclusion of exonS 21 and exclusion of exon 5 of the NMDA receptor R1 pre-mRNA. Involved in the apoB RNA editing activity. Increases COX2 mRNA stability and inhibits COX2 mRNA translation in epithelial cells after radiation injury. Modulates the cellular apoptosis program by regulating COX2-mediated prostaglandin E2 (PGE2) expression. Binds to (CUG)n triplet repeats in the 3'-UTR of transcripts such as DMPK. Binds to the muscle-specific splicing enhancer (MSE) intronic sites flanking the TNNT2 alternative exon 5. Binds preferentially to UG-rich sequences, in particular UG repeat and UGUU motifs. Binds to apoB mRNA, specifically to AU-rich sequences located immediatly upstream of the edited cytidine. Binds AU-rich sequences in the 3'-UTR of COX2 mRNA. Binds to an intronic RNA element responsible for the silencing of exon 21 splicing. Binds to (CUG)n repeats. May be a specific regulator of miRNA biogenesis. Binds to primary microRNA pri-MIR140 and, with CELF1, negatively regulates the processing to mature miRNA.
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基因功能參考文獻：
- Overexpression of CELF2 could reverse miR-615-3p's oncogenic functions. PMID: 29501762
- CUG-BP2 binds to AU-rich motifs found in the COX-2 mRNA 3'-UTR. PMID: 28935965
- Study provides evidence for a generalized position- dependent activity of CELF2 in splicing that can be used to predict its consequence on alternative splicing in a cell-type independent manner. PMID: 27096301
- These data suggest an interplay between CELF2 and hnRNP C as the mechanistic basis for activation-dependent alternative splicing of TRAF3 exon 8. PMID: 28031331
- Haplotype-dependent allele-specific methylation of CELF2 gene is associated with neurological disorders. PMID: 27153397
- CUGBP2 expression at the messenger RNA (mRNA) level was 2.2-fold lower and could be associated with high chemoresistance and early dissemination of pancreatic cancer. PMID: 26691217
- the genetic variant rs3740194 in CELF2 gene might be a valuable predictor for NPC prognosis PMID: 26314850
- Data show miR95 expression level positively related to glioma grade and its downregulation affects proliferation, invasion and apoptosis by targeting CELF2. MiR95 is identified as a putative therapeutic target and CELF2 as a potential tumor suppressor. PMID: 26165303
- a widespread role for the JNK-CELF2 axis in controlling splicing during T-cell activation, including a specific role in propagating JNK signaling. PMID: 26443849
- The A allele of rs2242451 in CUGBP2 might decrease Alzheimer disease risk in the Chinese Han population. PMID: 25801238
- novel mechanisms for CELF2 regulation that may broadly impact CELF2 expression across diverse cell types. PMID: 25870297
- There was evidence of association for recently-reported late-onset Alzheimer's disease risk loci, including BIN1 and CLU and CUGBP2 with APOE. PMID: 21379329
- Alternative splicing of LEF1 exon 6 is regulated during pre-TCR signaling in thymic development and in response to activation of the JSL1 T-cell line and this is driven by the activity of CELF2. PMID: 21444716
- results indicate the occurrence of a mis-splicing event in myotonic dystrophy type 1 that is induced neither by a loss of muscleblind-like 1 (MBNL1) function nor by a gain of CUGBP1 PMID: 21439371
- BRUNOL3 appears to be an important factor for thymus development and is therefore a candidate gene for the thymus hypoplasia/aplasia seen in partial monosomy 10p patients. PMID: 12110949
- Determination of ETR-3 protein domains required for RNA splicing. PMID: 14973222
- data suggest that CUGBP2 is a critical regulator of the apoptotic response to genotoxic injury in breast cancer cells PMID: 15033780
- Lipopolysaccharide inhibition of CUGBP2 is a prostaglandin-dependent mechanism. PMID: 15358864
- Developmental upregulation of apoB mRNA editing from approximately 3% to 88% begins with decreased levels of inhibitory CUG binding protein 2 (CUGBP2) expression. PMID: 16920700
- CUGBP2 overrides HuR and suppresses COX-2 mRNA translation. PMID: 17383427
- Data demonstrate that cells expressing CUGBP2 variant 1 undergo apoptosis during mitosis, suggesting mitotic catastrophe. PMID: 18258790
- Demonstrate that CUGBP2 inhibits Mcl-1 expression by inhibiting Mcl-1 mRNA translation, resulting in driving the cells to apoptosis during the G(2) phase of the cell cycle. PMID: 18292181
- Data demonstrate that PGE(2) protects colon cancer cells from ionizing radiation-induced mitotic catastrophe in part through suppression of CUGBP2 expression. PMID: 18325984
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亞細胞定位：Nucleus. Cytoplasm.
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蛋白家族：CELF/BRUNOL family
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組織特異性：Expressed in frontal cortex. Isoform 1 is expressed in brain and lung. Isoform 2 is expressed in heart, brain, placenta, lung, liver, kidney, skeletal muscle and pancreas. Isoform 4 is expressed in heart, lung, skeletal muscle, kidney and pancreas.
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