CEBPE Antibody
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中文名稱：CEBPE兔多克隆抗體
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貨號：CSB-PA194023
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規格：￥2024
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圖片：
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Western blot analysis of extracts from NIH-3T3 cells, using CEBPE antibody.
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) CEBPE Polyclonal antibody
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Uniprot No.：
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基因名：CEBPE
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宿主：Rabbit
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反應種屬：Human,Mouse,Rat
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免疫原：Synthesized peptide derived from internal of Human CEBPE.
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免疫原種屬：Homo sapiens (Human)
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克隆類型：Polyclonal
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純化方式：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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濃度：It differs from different batches. Please contact us to confirm it.
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產品提供形式：Liquid
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應用范圍：ELISA,WB
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推薦稀釋比：
Application Recommended Dilution WB 1:500-1:3000 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Transcriptional activator. C/EBP are DNA-binding proteins that recognize two different motifs: the CCAAT homology common to many promoters and the enhanced core homology common to many enhancers. Required for the promyelocyte-myelocyte transition in myeloid differentiation.
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基因功能參考文獻：
- CEBPE expression was highest in multipotent progenitor cells (S1) and declined sharply as cells progressed to B-cell-committed progenitors, including pre-B-I cells (S2), pre-B-II cells (S3) and immature B cells (S4) PMID: 26437776
- Data show that both CEBPE and SMARCD2 loss-of-function mutations identified in patients with neutrophil-specific granule deficiency (SGD) abolish the interaction with SWI/SNF and secondary granule gene expression, thus providing a molecular basis for this disease. PMID: 28369034
- PML/RARalpha synergizes with C/EBPepsilon to reactivate the C/EBPepsilon target G0S2, thereby contributing to All-trans retinoic acid -mediated acute promyelocytic leukemia differentiation and potentially, clinical remission. PMID: 27605212
- the rs7088318 (PIP4K2A) and rs2239633 (CEBPE) polymorphisms were not associated with ALL risk. PMID: 28476190
- The minor allele of the CEBPE variant associated with lower basophil count has been previously associated with Amerindian ancestry and higher risk of acute lymphoblastic leukemia in Hispanics. PMID: 28158719
- identified the rs45496295 (C > T) polymorphism in the heterozygous state in 73.9% of beta-thalassemia intermedia patients. PMID: 27829304
- variants within IKZF1, ARID5B, and CEBPE were associated with pediatric ALL risks. PMID: 27184773
- Genotypic and allelic frequencies differed significantly between cases and controls at IKZF1-rs4132601 (p=0.039, p=0.015) and ARID5B-rs10821936 (p=0.028, p=0.026). PMID: 27644650
- variants within IKZF1, ARID5B, and CEBPE were associated with increased acute lymphoblastic leukemia (ALL) risk, and the effects for ARID5B and CEBPE were most prominent in high-hyperdiploid ALL subtype in the California Hispanic population PMID: 25761407
- Data indicate no significant associations of transcription factors rs4132601 (IKZF1), rs7089424 (ARID5B) and rs2239633 (CEBPE) with risk of pediatric non-Hodgkin lymphoma (NHL). PMID: 25005032
- our study provided evidence that CEBPE rs2239633 variant is associated with decreased risk of childhood B-cell ALL in Europeans. PMID: 25938438
- A novel in-frame deletion in the leucine zipper domain of CEBPE leads to neutrophil-specific granule deficiency. PMID: 26019275
- During neutrophil development, acetylation of lysines 121 and 198 were found to be crucial for terminal neutrophil differentiation and the expression of neutrophil-specific granule proteins, including lactoferrin and collagenase. PMID: 25568349
- Studies indicate that the CCAAT/enhancer binding protein-epsilon (CEBPE) rs2239633 polymorphism was significantly associated with childhood acute lymphoblastic leukemiaacute lymphoblastic leukemia (ALL) risk. PMID: 25195121
- study found that previously identified childhood acute lymphoblastic leukemia susceptibility loci in ARID5B and CEBPE show consistent risk effects across both Hispanic and non-Hispanic White populations, providing compelling supportive evidence for susceptibility at these loci PMID: 23836053
- Germline variants in IKZF1, ARID5B, and CEBPE as risk factors for adult-onset acute lymphoblastic leukemia: an analysis from the GMALL study group. PMID: 24497567
- miR-130a is important for the regulation of the timed expression of C/EBP-epsilon during granulopoiesis. PMID: 24398327
- rs2239632 could regulate the expression of the CEBPE gene. Its risk allele (G) might increase the gene product and lead to leukemogenesis. A person with the allele or the corresponding haplotype might have increased susceptibility to ALL. PMID: 23719191
- rs4132601 in IKZF1 and rs2239633 in CEBPE are not significantly related to childhood childhood acute lymphoblastic leukemia. PMID: 23608171
- Case provides the first evidence that chromosome duplication and cryptic insertion produce the CEBPE-IGH fusion and that more than one CEBPE-IGH recombination can occur in a leukemic cell. PMID: 22137487
- The results above collectively show that C/EBPepsilon participates in all-trans retinoic acid induction of PI3Kgamma. PMID: 20661648
- causative agent in the development of Neutrophil specific granule deficiency PMID: 11753076
- Interacts with other transcription factors to regulate transcription of the gene encoding eosinophil granule major basic protein PMID: 12202480
- C/EBP epsilon is essential and sufficient for the expression of a particular subset of neutrophil secondary granule genes. PMID: 12515729
- Upon induction of maturation, C/EBP epsilon binds to the lactoferrin (LF) promoter, which correlates with LF expression. PMID: 12522000
- overexpression of C/EBPepsilon in myeloid cells leads to down-regulation of c-Myc PMID: 12947005
- Retinoic acid signaling in granulocytic differentiation involves regulated expression of CHOP protein and C/EBPepsilon in a coordinated fashion. PMID: 15308577
- Our data suggest that ATRA-induced regulation of Stat2, ICSBP and C/EBPepsilon is dependent on active Stat1, and that a failure to correctly regulate these transcription factors is associated with the inhibition of monocytic differentiation. PMID: 16918696
- Decreased Gfi-1 levels in our SGD patient, together with the mutant C/EBPepsilon, block secondary granules proteins expression, thereby contributing to the underlying etiology of the disease in our patient. PMID: 17244686
- Interaction of the activated NFkappaB pathway and C/EBP-epsilon may be important in selective activation of a subset of C/EBP-epsilon-responsive genes. PMID: 17255362
- The type IV isoform of PML interacted with PU.1, promoted its association with p300, and then enhanced PU.1-induced transcription and granulocytic differentiation and PU.1 directly activates the transcription of the C/EBPepsilon gene. PMID: 17562868
- C/EBP epsilon is a critical transcription factor for tumor necrosis factor alpha-induced up-regulation of phospholipid hydroperoxide glutathione peroxidase (PHGPx) expression in non-differentiated HL60 cells. PMID: 17688422
- C/EBP- isoforms can reprogram myeloid lineage commitment and differentiation consistent with their predicted activities based on activator and repressor domains and in vitro functional activities PMID: 18832658
- Substantial quantitities of C-EBPepsilon are expressed in human neutrophils, especially the p14 and p32 variants. PMID: 19109189
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相關疾病：Specific granule deficiency 1 (SGD1)
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亞細胞定位：Nucleus.
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蛋白家族：BZIP family, C/EBP subfamily
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組織特異性：Strongest expression occurs in promyelocyte and late-myeloblast-like cell lines.
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