CDYL Antibody

中文名稱：

CDYL兔多克隆抗體
貨號：

CSB-PA896685LA01HU
規(guī)格：

￥440
圖片：
Immunohistochemistry of paraffin-embedded human glioma using CSB-PA896685LA01HU at dilution of 1:100

Western Blot
Positive WB detected in: K562 whole cell lysate
All lanes: CDYL antibody at 3µg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 67, 61, 35, 46 kDa
Observed band size: 67 kDa
其他：

產(chǎn)品詳情
產(chǎn)品評價
相關產(chǎn)品
靶點詳情

產(chǎn)品詳情

產(chǎn)品名稱：

Rabbit anti-Homo sapiens (Human) CDYL Polyclonal antibody
Uniprot No.：

Q9Y232
基因名：

CDYL
別名：

CDY-like antibody; CDY-like autosomal antibody; Cdyl antibody; CDYL: chromodomain protein Y-like antibody; CDYL1 antibody; CDYL1_HUMAN antibody; chromodomain protein Y chromosome-like 6 antibody; Chromodomain protein Y like antibody; Chromodomain Y-like protein antibody; DKFZP586C1622 antibody; MGC131936 antibody; OTTHUMP00000015984 antibody; OTTHUMP00000211185 antibody; OTTHUMP00000211186 antibody; OTTHUMP00000211189 antibody; testis-specific chromodomain Y-like protein antibody; Weakly similar to enoyl-CoA hydratase [H.sapiens] antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Chromodomain Y-like protein (8-260AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產(chǎn)品，CDYL Antibody (CSB-PA896685LA01HU)，的標記方式是Non-conjugated。對于CDYL Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產(chǎn)品名稱	應用
HRP	CSB-PA896685LB01HU	CDYL Antibody, HRP conjugated	ELISA
FITC	CSB-PA896685LC01HU	CDYL Antibody, FITC conjugated
Biotin	CSB-PA896685LD01HU	CDYL Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產(chǎn)品提供形式：

Liquid
應用范圍：

ELISA, WB, IHC

推薦稀釋比：

Application	Recommended Dilution
WB	1:200-1:3000
IHC	1:20-1:200

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

功能：

Chromatin reader protein that recognizes and binds histone H3 trimethylated at 'Lys-9', dimethylated at 'Lys-27' and trimethylated at 'Lys-27' (H3K9me3, H3K27me2 and H3K27me3, respectively). Part of multimeric repressive chromatin complexes, where it is required for transmission and restoration of repressive histone marks, thereby preserving the epigenetic landscape. Required for chromatin targeting and maximal enzymatic activity of Polycomb repressive complex 2 (PRC2); acts as a positive regulator of PRC2 activity by bridging the pre-existing histone H3K27me3 and newly recruited PRC2 on neighboring nucleosomes. Acts as a corepressor for REST by facilitating histone-lysine N-methyltransferase EHMT2 recruitment and H3K9 dimethylation at REST target genes for repression. Involved in X chromosome inactivation in females: recruited to Xist RNA-coated X chromosome and facilitates propagation of H3K9me2 by anchoring EHMT2. Promotes EZH2 accumulation and H3K27me3 methylation at DNA double strand breaks (DSBs), thereby facilitating transcriptional repression at sites of DNA damage and homology-directed repair of DSBs. Required for neuronal migration during brain development by repressing expression of RHOA. By repressing the expression of SCN8A, contributes to the inhibition of intrinsic neuronal excitability and epileptogenesis. In addition to acting as a chromatin reader, acts as a hydro-lyase. Shows crotonyl-coA hydratase activity by mediating the conversion of crotonyl-CoA ((2E)-butenoyl-CoA) to beta-hydroxybutyryl-CoA (3-hydroxybutanoyl-CoA), thereby acting as a negative regulator of histone crotonylation. Histone crotonylation is required during spermatogenesis; down-regulation of histone crotonylation by CDYL regulates the reactivation of sex chromosome-linked genes in round spermatids and histone replacement in elongating spermatids. By regulating histone crotonylation and trimethylation of H3K27, may be involved in stress-induced depression-like behaviors, possibly by regulating VGF expression.; Not able to recognize and bind histone H3K9me3, histone H3K27me2 and histone H3K27me3, due to the presence of a N-terminal extension that inactivates the chromo domain.; Not able to recognize and bind histone H3K9me3, histone H3K27me2 and histone H3K27me3, due to the absence of the chromo domain. Acts as a negative regulator of isoform 2 by displacing isoform 2 from chromatin.
基因功能參考文獻：
1. CDYL plays an important role in the maintenance of repressive histone marks during replication, providing a mechanism for understanding of the epigenetic inheritance and memory. PMID: 28402439
2. CDYL negatively regulates histone crotonylation by acting as a crotonyl-CoA hydratase to convert crotonyl-CoA to beta-hydroxybutyryl-CoA and suggest role in spermatogenesis. PMID: 28803779
3. The epigenetic regulators CDYL and EZH2 to dendrite morphogenesis and might shed new light on our understanding of the regulation of the neurodevelopment. PMID: 24671995
4. These findings suggest that h-CDYLb and G9a are cooperatively involved in hepatocellular carcinomas PMID: 23629948
5. CDYL functions as a molecular bridge between PRC2 and the repressive chromatin mark H3K27me3, forming a positive feedback loop to facilitate the establishment and propagation of H3K27me3 modifications along the chromatin PMID: 22009739
6. Results imply that multimeric binding to H3K9me3 by CDYL1b homomeric complexes is essential for efficient chromatin targeting. PMID: 19808672
7. Chromodomain on Y-like (CDYL) is identified as a REST corepressor that physically bridges REST and the histone methylase G9a to repress transcription. PMID: 19061646
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亞細胞定位：

[Isoform 2]: Nucleus. Chromosome.
組織特異性：

Expressed in the hippocampus with reduced expression in epileptic tissue compared to normal adjacent tissue (at protein level). Ubiquitous. Expressed at moderate levels in all tissues examined. Isoform 2: Most abundantly expressed isoform.
數(shù)據(jù)庫鏈接：

HGNC: 1811

OMIM: 603778

KEGG: hsa:9425

STRING: 9606.ENSP00000380718

UniGene: Hs.269092

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