CDK2AP1 Antibody

說明書

中文名稱：

CDK2AP1兔多克隆抗體
貨號：

CSB-PA002179
規格：

￥1090
圖片：
Western Blot analysis of HeLa cells using DOC-1 Polyclonal Antibody
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

Uniprot No.：

O14519
基因名：

CDK2AP1
別名：

CDK2 A1 antibody; CDK2 associated protein 1 antibody; CDK2-associated protein 1 antibody; CDK2AP1 antibody; CDKA1 antibody; CDKA1_HUMAN antibody; Cyclin dependent kinase 2 associated protein 1 antibody; Cyclin-dependent kinase 2-associated protein 1 antibody; Deleted in oral cancer 1 antibody; DOC 1 antibody; DOC 1 related protein antibody; DOC 1R antibody; DOC-1 antibody; DOC1 antibody; DOC1R antibody; DORC1 antibody; p12DOC 1 antibody; Putative oral cancer suppressor antibody; ST19 antibody
宿主：

Rabbit
反應種屬：

Human,Mouse
免疫原：

Synthesized peptide derived from the Internal region of Human DOC-1.
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
產品提供形式：

Liquid
應用范圍：

WB, ELISA

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:2000
ELISA	1:5000

Protocols：

Western Blotting (WB) Protocol
ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

specific inhibitor of the cell-cycle kinase CDK2.
基因功能參考文獻：
1. A compelling relationship exists between high CDK2AP1 mRNA expression and lower TNM classification of breast cancer, which is consistent with CDK2AP1 having a tumour-suppressive function. PMID: 30343278
2. Knockdown of CDK2AP1 in hESCs results in increased p53 and enhances differentiation and favors it over a self-renewal fate. PMID: 29734353
3. DOC1 re-expression in oral cancer cells causes a reversal of EMT. DOC1 promotes NURD binding to a subset of target loci. PMID: 28683324
4. The simultaneous overexpression of p12CDK2-AP1 and CD82 significantly suppressed the in vivo tumor growth. PMID: 27349208
5. knockdown of CDK2AP1 in primary human fibroblasts reduced proliferation and induced premature senescence, with the observed phenotype being p53 dependent PMID: 25785833
6. In summary, p12CDK2AP1 expression in myxofibrosarcoma cells induces G0/G1 arrest and mitochondria dependent proapoptotic activity and down-regulation of p12CDK2AP1 by shRNAi results in up-regulation of the CDK2 transcript and protein. PMID: 24889487
7. Study reports that knockdown of CDK2AP1 by RNAi in glioma cells could effectively inhibit cell proliferation by inducing cell cycle arrest and apoptosis PMID: 24620959
8. CDK2AP1 plays an important role in modulating the growth and tumorigenesis of lung cancer cells. PMID: 23404055
9. Low CDK2AP1 expression is common and associated with adverse prognosis in nasopharyngeal carcinoma. PMID: 22791769
10. Human cyclin-dependent kinase 2-associated protein 1 (CDK2AP1) is dimeric in its disulfide-reduced state, with natively disordered N-terminal region PMID: 22427660
11. exerts its effect on stem cell maintenance/differentiation through epigenetic regulation [review] PMID: 21865592
12. In comparison with the healthy gingiva, the expression of Doc-1 was decreased, whereas the expression of S100A7 was upregulated in all oral lesions. PMID: 21740085
13. P12(CDK2AP1) is downregulated by miR-21 PMID: 21328460
14. Missing down-regulation of the tumor-suppressor gene DOC-1, might exert protective effects and counteract malignant transformation of benign, proliferating lesions of the oral cavity. PMID: 21187770
15. Data support the role of cdk2ap1 as a tumor suppressor gene that can regulate squamous cell carcinoma growth in a cell autonomous manner through decreases in invasiveness and a non-cell autonomous manner through decreases in angiogenesis phenotypes. PMID: 20541561
16. The combination of an increased expression of the antimicrobial peptide DEFA-4, the oncogene S100-A7, epidermal growth factor, and tenascin-c, and a decreased Doc-1 expression in oral leukoplakia might characterize its potency of malignant transformation. PMID: 20727496
17. Results indicate that DOC-1 is a bona fide subunit of the Mi-2/NuRD chromatin remodeling complex. PMID: 20523938
18. CDK2AP1 is a novel multiple sclerosis susceptibility loci, and it's risk allele correlates with diminished RNA expression of the cell cycle regulator CDK2AP1 PMID: 20555355
19. Data show low or moderate methylation was found in seven selected genes BAD, BBC3, CAV1, CDK2AP1, NPM1, PRKCDBP and THEM4. PMID: 19679565
20. DOC1 has a differential expression in microsatellite-unstable human colorectal neoplasms. PMID: 13679870
21. plays a role in TGF-beta1-mediated growth suppression by modulating CDK2 activities and pRB phosphorylation PMID: 14744761
22. p12CDK2-AP1 forms nuclear homodimers in contact inhibited normal diploid cells and dimerization of p12 is a necessary process for the growth inhibition effect by p12 PMID: 15840587
23. Resistance to TGF-beta 1-induced growth suppression is due to the disruption of its signaling pathway as a consequence of reduced or lost p12(CDK2-AP1). PMID: 17217620
24. the del T poly (T) 8 observed in the 3'-UTR of the CDK2-AP1 gene in human microsatellite unstable colorectal cancer is functionally significant and results in decreased CDK2-AP1 expression PMID: 17689689
25. expression negatively associated with a more advanced depth of tumor invasion and stage in gastric carcinoma PMID: 19279387
26. p12CDK2-AP1 is associated with tumor progression and a poor prognosis in esophageal squamous cell carcinoma. PMID: 19513502
27. The expression of cdk2ap1 correlated with a reduction in cellular growth, irrespective of inhibition or stimulation of androgen receptor (AR) signaling pathways PMID: 19585490
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蛋白家族：

CDK2AP family
數據庫鏈接：

HGNC: 14002

OMIM: 602198

KEGG: hsa:8099

STRING: 9606.ENSP00000261692

UniGene: Hs.433201

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