CDK13 Antibody

中文名稱：

CDK13兔多克隆抗體
貨號：

CSB-PA613482LA01HU
規(guī)格：

￥440
圖片：
Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA613482LA01HU at dilution of 1:100
其他：

產(chǎn)品詳情
產(chǎn)品評價
相關(guān)產(chǎn)品
靶點(diǎn)詳情

產(chǎn)品詳情

產(chǎn)品名稱：

Rabbit anti-Homo sapiens (Human) CDK13 Polyclonal antibody
Uniprot No.：

Q14004
基因名：

CDK13
別名：

CDC2 related protein kinase 5 antibody; CDC2-related protein kinase 5 antibody; CDC2L antibody; CDK13 antibody; CDK13_HUMAN antibody; cell division controller cholinesterase related antibody; cell division cycle 2 like 5 (cholinesterase related cell division controller) antibody; cell division cycle 2 like 5 antibody; Cell division cycle 2 like protein kinase 5 antibody; Cell division cycle 2-like protein kinase 5 antibody; Cell division protein kinase 13 antibody; CHED antibody; Cholinesterase related cell division controller antibody; Cholinesterase-related cell division controller antibody; cyclin dependent kinase 13 antibody; Cyclin-dependent kinase 13 antibody; hCDK13 antibody
宿主：

Rabbit
反應(yīng)種屬：

Human
免疫原：

Recombinant Human Cyclin-dependent kinase 13 protein (1-170AA)
免疫原種屬：

Homo sapiens (Human)

標(biāo)記方式：

Non-conjugated

本頁面中的產(chǎn)品，CDK13 Antibody (CSB-PA613482LA01HU)，的標(biāo)記方式是Non-conjugated。對于CDK13 Antibody，我們還提供其他標(biāo)記。見下表：

標(biāo)記方式	貨號	產(chǎn)品名稱	應(yīng)用
HRP	CSB-PA613482LB01HU	CDK13 Antibody, HRP conjugated	ELISA
FITC	CSB-PA613482LC01HU	CDK13 Antibody, FITC conjugated
Biotin	CSB-PA613482LD01HU	CDK13 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

ELISA, IHC

推薦稀釋比：

Application	Recommended Dilution
IHC	1:20-1:200

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點(diǎn)詳情

功能：

Cyclin-dependent kinase which displays CTD kinase activity and is required for RNA splicing. Has CTD kinase activity by hyperphosphorylating the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit RPB1, thereby acting as a key regulator of transcription elongation. Required for RNA splicing, probably by phosphorylating SRSF1/SF2. Required during hematopoiesis. In case of infection by HIV-1 virus, interacts with HIV-1 Tat protein acetylated at 'Lys-50' and 'Lys-51', thereby increasing HIV-1 mRNA splicing and promoting the production of the doubly spliced HIV-1 protein Nef.
基因功能參考文獻(xiàn)：
1. Heterozygous constitutional CDK13 mutations in 3 patients cause intellectual disability without cardiac defects. PMID: 29222009
2. CDK13 RNA over-editing sites mediated by ADAR1 may serve as novel cancer driver events in HCC progression. PMID: 29996118
3. heterozygous, likely dominant negative mutations affecting the protein kinase domain of the CDK13 gene result in a recognisable, syndromic form of intellectual disability, with or without congenital heart disease. PMID: 29021403
4. Mutation in CHK13 gene is associated with congenital heart defects. PMID: 27479907
5. Detailed phenotypic and molecular characterisation of 9 individuals with pathogenic variants in CDK13 is provided. Two individuals had novel CDK13 variants (p.Asn842Asp, p.Lys734Glu), while the remaining seven unrelated individuals had a recurrent, previously published p.Asn842Ser variant. PMID: 28807008
6. CDK13 gene is amplified in different types of cancer indicate that this kinase can contribute to cancer development in human. PMID: 26886422
7. CDK12 and CDK13 losses in HCT116 cells preferentially affect expression of DNA damage response. PMID: 25561469
8. High CDK13 expression is associated with pancreatic cancer. PMID: 25216700
9. Coincidently amplified CDK13, GMNN, and CENPF genes can play a role as common cancer-driver genes in human cancers. PMID: 22912832
10. CDK13 interacts with cyclin K, and is required for self-renewal in ES cells. PMID: 22547058
11. Data demonstrate that CDC2L5 is located in the nucleoplasm, where it directly interacts with the ASF/SF2-associated protein p32, a protein involved in splicing regulation. PMID: 16721827
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相關(guān)疾?。?/div>
Congenital heart defects, dysmorphic facial features, and intellectual developmental disorder (CHDFIDD)
亞細(xì)胞定位：

Nucleus speckle.
蛋白家族：

Protein kinase superfamily, CMGC Ser/Thr protein kinase family, CDC2/CDKX subfamily
組織特異性：

Expressed in fetal brain, liver, muscle and in adult brain. Also expressed in neuroblastoma and glioblastoma tumors.
數(shù)據(jù)庫鏈接：

HGNC: 1733

OMIM: 603309

KEGG: hsa:8621

STRING: 9606.ENSP00000181839

UniGene: Hs.233552

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