CDH2 Antibody
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中文名稱：CDH2兔多克隆抗體
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貨號：CSB-PA553061
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規格：￥1100
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圖片：
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Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane: Human brain malignant glioma tissue, Primary antibody: CSB-PA553061(CDH2 Antibody) at dilution 1/450, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 2 minutes
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其他：
產品詳情
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Uniprot No.：
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基因名：
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別名：CDH2; CDHN; NCAD; Cadherin-2; CDw325; Neural cadherin; N-cadherin; CD antigen CD325
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宿主：Rabbit
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反應種屬：Human,Mouse,Rat
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免疫原：Synthetic peptide of Human CDH2
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
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抗體亞型：IgG
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純化方式：Antigen affinity purification
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
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產品提供形式：Liquid
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應用范圍：ELISA,WB
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推薦稀釋比：
Application Recommended Dilution ELISA 1:1000-1:2000 WB 1:200-1:1000 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Calcium-dependent cell adhesion protein; preferentially mediates homotypic cell-cell adhesion by dimerization with a CDH2 chain from another cell. Cadherins may thus contribute to the sorting of heterogeneous cell types. Acts as a regulator of neural stem cells quiescence by mediating anchorage of neural stem cells to ependymocytes in the adult subependymal zone: upon cleavage by MMP24, CDH2-mediated anchorage is affected, leading to modulate neural stem cell quiescence. Plays a role in cell-to-cell junction formation between pancreatic beta cells and neural crest stem (NCS) cells, promoting the formation of processes by NCS cells. CDH2 may be involved in neuronal recognition mechanism. In hippocampal neurons, may regulate dendritic spine density.
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基因功能參考文獻：
- Human keratinocyte cells reduce the N-cadherin levels of co-cultured melanoma cells. Cell-to-cell contact is necessary for this keratinocyte-mediated N-cadherin reduction. Keratinocytes reduce intracellular calcium in co-cultured melanoma cells. PMID: 29902459
- The FGFR4-388arg variant promotes lung cancer progression by N-cadherin induction. PMID: 29402970
- This study showed that the significant N-cadherin expression especially in high-grade meningioma group. PMID: 29297710
- Our experiments presented a new mechanism adopted by GDNF supporting glioma development and indicated a possible therapeutic potential via the inhibition of proN-cadherin/FGFR1 interaction. PMID: 29750313
- In patients with gastric cancer, the strong expression of N-cadherin in lymph nodes correlated with more lymph nodes metastasis, an advanced stage, and poor prognosis PMID: 28247164
- Regulatory networks specifying cortical interneurons from human embryonic stem cells reveal roles for CHD2 in interneuron development PMID: 29229852
- A study with nonsyndromic cleft lip with or without cleft palate (NSCL+/-P) cases (N=292) and controls (N=287) established association of a SNP in intron 2 of CDH2 with NSCL+/-P as a risk factor. PMID: 29524576
- Results show that N-cadherin is highly expressed in 70% of patients with glioma. However, N-cadherin, as a representative EMT marker, have limited prognostic value in glioma. Nonetheless, the EMT process in gliomas may be compounded by enhanced N-cadherin expression supported by unfavorable prognostic outcomes. PMID: 28851312
- Findings reveal the importance of CDH2-mediated cell contacts in preserving features of the juvenile nucleus pulposus cell phenotype. PMID: 27292569
- Tumor-promoting role of N-cadherin in thyroid cancer was closely related to the activities of the MAPK/Erk, the phosphatidylinositol-3-kinase (PI3K)/Akt and p16/Rb signaling pathways. PMID: 28042956
- Triple negative breast cancer cells surviving short-term chemotherapy treatment are more invasive than bulk tumor cells. Cell surface pro-N-cadherin expression is associated with the invasive and chemo-resistant behaviors of this tumor cell subset. PMID: 27768598
- Sec8 regulates N-cadherin expression by controlling Smad3 and Smad4 expression through CBP, thereby mediating the epithelial-mesenchymal transition. PMID: 27769780
- Results found that the N-glycan at N402 is comprised of beta 1,6 GlcNAc branching and that in glioma, deficient N402 N-glycosylation destabilises N-cadherin and leads to its proteasomal degradation. Destabilisation of N-cadherin inhibits cadherin-mediated cell-cell adhesion and promotes cell migration. Our findings imply that the control of N-cadherin stability by N-glycosylation is important in glioma migration. PMID: 27864899
- In adrenocortical carcinomas, the loss of N-cadherin is a frequent phenomenon while the existence of TERT promoter mutations is not, and nuclear telomerase expression is present in only a minority of cases. PMID: 27886397
- High CDH2 expression is associated with M2-type acute myeloid leukemia. PMID: 27064800
- Migration of bone marrow-mesenchymal stem cells in response to TGF-beta was mediated through N-cadherin and noncanonical TGF-beta signals. PMID: 28213973
- Studied the roles of MIRN145 in lung adenocarcinoma (LAC) and its targeting of N-cadherin. Knockdown of N-cadherin inhibited invasion and migration of LAC cell lines similar to overexpression of MIRN45. PMID: 28120164
- Genetic mutations in CDH2-encoded N-cadherin may represent a novel pathogenetic basis for arrhythmogenic cardiomyopathy. PMID: 28326674
- Extracellular and intracellular cleavage of N-cadherin might be involved in elevated MMP-9 expression enhancing tumor cell invasion. PMID: 27737648
- a mechanism where the membrane organization of CD82, through specific posttranslational modifications, regulates N-cadherin clustering and membrane density, which impacts the in vivo trafficking of AML cells. PMID: 26592446
- fluorescent imaging to demonstrate Ncad-mediated single cell responses to developmental cues within hydrogels towards chondrogenesis. PMID: 27106637
- Our data demonstrate that N-Cadherin was markedly overexpressed and miR-199b-5p was significantly downregulated in hepatocellular carcinoma (HCC). MiR-199b-5p exerts inhibitory effects on EMT, and directly targets N-cadherin in HCC, supporting the potential utility of miR-199b-5p as a promising strategy to treat HCC PMID: 28588321
- Study demonstrates a critical role of presynaptic cadherin/catenin/p140Cap cell adhesion complexes in stabilizing functional synapses and spines in the developing neocortex. PMID: 28641114
- investigated the in vitro tumor/metastasis suppressor effects of plakoglobin in ovarian cancer cell lines with mutant p53 expression and different cadherin profiles PMID: 27144941
- These results uncover a new role for p120 catenin bound to the N-cadherin precursor ensuring its trafficking through the biosynthetic pathway towards the cell surface. PMID: 27254316
- Finding that the cells expressing N-cadherin gave rise to tumors with no expression of N-cadherin is in agreement with the classical view of epithelial to mesenchymal transition. Epithelial to mesenchymal transition and N-cadherin are associated with dissemination and not with the ability to establish new tumor growth. PMID: 27224422
- These data implicate CDH2 mutations as novel genetic causes of Arrhythmogenic Right Ventricular Cardiomyopathy and contribute to a more complete identification of disease genes involved in cardiomyopathy. PMID: 28280076
- High expression of N-cadherin is associated with bladder cancer. PMID: 27683053
- Snail and N-cadherin are constitutively and inducibly expressed in papillary thyroid carcinoma PMID: 26219900
- SFMSCs increased through upregulation of the activated lymphocyte cell adhesion molecule (ALCAM) and N-cadherin by microRNA-192 and -218 downregulation, similar to BMMSCs and ADMSCs. PMID: 28039611
- the synergy between N-cadherin and FGFR signalling that ensure cellular reorganization during cell movements, mainly during cancer cell migration and metastasis but also during developmental processes. PMID: 27320194
- Underexpression of CDH2 is associated with adrenocortical tumors. PMID: 27468715
- Of the seven polymorphisms, two reached statistical significance for obsessive-compulsive disorder under additive and codominant models of inheritance PMID: 26093892
- Targeting N-cadherin may be a promising therapeutic approach, particularly in cisplatin-resistant, therapy refractory and metastatic Germ cell tumor. PMID: 26451610
- Metformin's anti-cancer therapeutic effect is mediated through different molecular mechanism in wild-type vs. deficient N-cadherin cancer cells. PMID: 26359363
- Expression data of NCAD shows no association with advanced gastric cancer brain metastasis. PMID: 26260219
- CDH2 was found to be a susceptibility gene for Gilles de la Tourette syndrome in a Danish cohort. PMID: 26032459
- Existing knowledge regarding the role of CDH2 and CDH11 during development and differentiation in vivo and in vitro is reviewed. [review] PMID: 25771201
- N-cadherin was widely expressed in CRC cell lines and silencing of N-cadherin suppressed the proliferation and migration of the CRC cell line HT-29 by upregulating E-cadherin, suggesting a potential role of N-cadherin in inducing EMT. PMID: 25936636
- N-cadherin and connexin 43 expression in in group of diffuse astrocytomas and anaplastic astrocytomas may be evidence for their role in tumor formation and progression PMID: 25386667
- Foxn3 is a direct transcriptional suppressor of N-cadherin in colorectal metastasis tissues. PMID: 26069251
- the expression of N-cadherin was associated with Vasculogenic mimicry formation in esophageal squamous cell carcinoma PMID: 25575439
- Results suggest that N-cadherin may promote motility and invasiveness through distinct mechanisms and that beta-catenin may be an integral mediator of N-cadherin-dependent invasive signaling in oral epithelia. PMID: 25175499
- Results demonstrate that miR-194 affected the growth and metastasis of osteosarcoma cells both in vitro and in vivo suggesting that miR-194 functions as tumor suppressor gene probably by downregulating CDH2 and IGF1R. PMID: 25096247
- association of beta-catenin with N-cadherin is regulated by actin polymerization during contractile activation PMID: 25713069
- Decreased N-cadherin expression is linked to increased ADAM-10 expression in atherosclerotic lesions. PMID: 24985126
- This indicates that similar biofunctionalization approaches based on N-cadherin and L1 can be translated to 3-D "transplantable" scaffolds with enhanced neurotrophic behaviors. PMID: 24914828
- miR-199a targeted the sequence within the 3'UTR of the N-cadherin mRNA and suppressed the TGF-beta1-induced increase in the protein level of N-cadherin in a manner independent of SNAI1. PMID: 25041364
- N-cadherin and CD133 expressions are strongly correlated and N-cadherin appears as a potential breast cancer metastases marker in a specific patient subpopulation. PMID: 24962344
- High N-cadherin expression is associated with malignant bone and soft tissue tumors. PMID: 23799912
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亞細胞定位：Cell membrane; Single-pass type I membrane protein. Cell membrane, sarcolemma. Cell junction. Cell surface.
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