CDCA8 Antibody
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中文名稱：CDCA8兔多克隆抗體
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貨號：CSB-PA005031GA01HU
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規格：￥3,900
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其他：
產品詳情
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Uniprot No.：
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基因名：CDCA8
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別名：BOR antibody; BOREA_HUMAN antibody; Borealin antibody; CDCA8 antibody; Cell division cycle associated 8 antibody; cell division cycle associated protein 8 antibody; Cell division cycle-associated protein 8 antibody; Dasra B antibody; Dasra-B antibody; DasraB antibody; FLJ10468 antibody; FLJ12042 antibody; hDasra B antibody; hDasra-B antibody; MESRGP antibody; OTTHUMP00000004514 antibody; pluripotent embryonic stem cell related gene 3 protein antibody; Pluripotent embryonic stem cell-related gene 3 protein antibody
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宿主：Rabbit
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反應種屬：Human,Mouse,Rat
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免疫原：Human CDCA8
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免疫原種屬：Homo sapiens (Human)
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抗體亞型：IgG
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純化方式：Antigen Affinity Purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
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產品提供形式：Liquid
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應用范圍：ELISA,WB,IHC
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
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靶點詳情
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功能：Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Major effector of the TTK kinase in the control of attachment-error-correction and chromosome alignment.
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基因功能參考文獻：
- Results show that CDCA8 is overexpressed in bladder cancer (BC) and its high levels are correlated with poor clinicopathological features of BC patients. Therefore, CDCA8 may act as a novel prognostic marker in the diagnosis of patients with BC. PMID: 30142792
- These results were well correlated with the same gene expression pattern analysed in the thyroid tissue of the patient with BOREALIN-p.R114W. These studies open new avenues in the genetics of TD in humans. PMID: 28025328
- Borealin dimerization mediates chromosomal passenger complex checkpoint function by enhancing localization to centromeres and kinetochores. PMID: 25854549
- enhanced CDCA8 promoter activities by NF-Y overexpression and reduced CDCA8 transcription by NF-Y knockdown further verified that NF-Y is a positive regulator of CDCA8 transcription. PMID: 26170459
- In colorectal cancer patients, Borealin expression was positively correlated with age, lymph node metastasis and neoplasm staging. PMID: 25260804
- These findings reveal a previously unrecognized but direct link between HP1 and CPC localization in the centromere and illustrate the critical role of borealin-HP1 interaction in orchestrating an accurate cell division. PMID: 24917673
- Borealin interacts directly with the Snf7 components of ESCRT-III in human cells.the Borealin central region encompassing residues 110-207 was both necessary & sufficient to bind to CHMP4C. PMID: 22724069
- MLL5 functionally interacts with Borealin, facilitates the expression of chromosomal passenger complex, and hence contributes to mitotic fidelity and genomic integrity. PMID: 22797924
- important role for phosphorylation of Borealin at S219 in the proper progression through mitosis PMID: 20803554
- Data show that INCENP has an important role in stabilizing the chromosomal passenger complex, and that Borealin acts to promote binding of Survivin to INCENP. PMID: 16239925
- Cell cycle-regulated chromosomal passenger protein whose aberrant expression and nuclear accumulation are linked to poor prognosis for gastric cancer. PMID: 16427043
- A functional module within the chromosomal passenger complex involving the inner centromere protein INCENP, Survivin, and Borealin. PMID: 16571674
- Borealin is phosphorylated during mitosis. Neither residue S165, T106 nor phosphorylation of borealin by Aurora B Kinase is required to generate the mitotic, shifted form of Borealin. PMID: 17241471
- Suppression of CDCA8 expression with small interfering RNA against CDCA8 significantly suppressed the growth of lung cancer cells. PMID: 17483322
- It is recorded that borealin is a cell cycle regulator, down-regulated in response to p53/Rb-signaling, and up-regulated in many types of cancerous tissues. PMID: 17716930
- mitotic regulator Survivin binds as a monomer to its functional interactor Borealin PMID: 17881355
- Borealin and INCENP associate with the helical domain of Survivin to form a tight three-helical bundle. PMID: 17956729
- Borealin plays a crucial role in the early mouse embryonic development PMID: 18311593
- Data describe a mitotic SUMO2/3 conjugation-deconjugation cycle of Borealin and further assign a regulatory function of RanBP2 and SENP3 in the mitotic SUMO pathway. PMID: 18946085
- found that substitutions at Borealin T230, recently identified as an Mps1 phosphorylation site, can modulate the dimerization state of Borealin PMID: 19530738
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亞細胞定位：Nucleus, nucleolus. Cytoplasm. Cytoplasm, cytoskeleton, spindle. Chromosome, centromere.
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蛋白家族：Borealin family
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數據庫鏈接：
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