CDC42BPB Antibody
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中文名稱：CDC42BPB兔多克隆抗體
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貨號：CSB-PA936608
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規格：￥2024
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圖片：
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Western blot analysis of extracts from COLO cells, using MRCKB antibody. -
Immunohistochemistry analysis of paraffin-embedded human brain tissue using MRCKB antibody.
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) CDC42BPB Polyclonal antibody
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Uniprot No.：
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基因名：CDC42BPB
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宿主：Rabbit
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反應種屬：Human,Mouse,Rat
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免疫原：Synthesized peptide derived from internal of Human MRCKB.
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免疫原種屬：Homo sapiens (Human)
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克隆類型：Polyclonal
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純化方式：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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濃度：It differs from different batches. Please contact us to confirm it.
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產品提供形式：Liquid
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應用范圍：ELISA,WB,IHC
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推薦稀釋比：
Application Recommended Dilution WB 1:500-1:3000 IHC 1:50-1:100 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration. Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2. In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration. Phosphorylates PPP1R12A. In concert with FAM89B/LRAP25 mediates the targeting of LIMK1 to the lamellipodium resulting in its activation and subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation.
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基因功能參考文獻：
- these results provide further validation for MRCK involvement in regulation of cancer cell invasion. PMID: 21949762
- Cdc42-dependent formation of the ZO-1/MRCKbeta complex at the leading edge controls cell migration. PMID: 21240187
- Q-PCR results demonstrated VH2 genes were overexpressed in ankylosing spondylitis patients. The sequence analysis revealed the majority of them contained CDC42 binding protein kinase Beta (CDC42 BPB) genes. PMID: 20177145
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亞細胞定位：Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell junction. Cell projection, lamellipodium.
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蛋白家族：Protein kinase superfamily, AGC Ser/Thr protein kinase family, DMPK subfamily
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組織特異性：Expressed in all tissues examined, with high levels in heart, brain, placenta and lung.
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數據庫鏈接：
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