CD84 Antibody

說明書

中文名稱：

CD84兔多克隆抗體
貨號：

CSB-PA004964ESR1HU
規格：

￥440
圖片：
Western blot
All lanes: SLAM family member 5 antibody at 6μg/ml + Mouse liver tissue
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 39, 37, 32, 31, 27, 25 kDa
Observed band size: 39 kDa

Immunohistochemistry of paraffin-embedded human thymus tissue using CSB-PA004964ESR1HU at dilution of 1: 100
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) CD84 Polyclonal antibody
Uniprot No.：

Q9UIB8
基因名：

CD84
別名：

CD_antigen=CD84 antibody; CD84 antibody; CD84 antigen antibody; CD84 molecule antibody; CDw84 antibody; Cell surface antigen MAX.3 antibody; hCD84 antibody; Hly9 beta antibody; Hly9-beta antibody; Leucocyte differentiation antigen CD84 antibody; Leukocyte Antigen antibody; Leukocyte antigen CD84 antibody; Leukocyte differentiation antigen antibody; Leukocyte differentiation antigen CD84 antibody; LY9B antibody; mCD84 antibody; Signaling lymphocytic activation molecule 5 antibody; SLAF5_HUMAN antibody; SLAM family member 5 antibody; SLAMF5 antibody
宿主：

Rabbit
反應種屬：

Human, Mouse
免疫原：

Recombinant Human SLAM family member 5 protein (22-225AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

Antigen Affinity Purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
產品提供形式：

Liquid
應用范圍：

ELISA, WB, IHC

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:2000
IHC	1:20-1:200

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. Can mediate natural killer (NK) cell cytotoxicity dependent on SH2D1A and SH2D1B. Increases proliferative responses of activated T-cells and SH2D1A/SAP does not seem be required for this process. Homophilic interactions enhance interferon gamma/IFNG secretion in lymphocytes and induce platelet stimulation via a SH2D1A-dependent pathway. May serve as a marker for hematopoietic progenitor cells Required for a prolonged T-cell:B-cell contact, optimal T follicular helper function, and germinal center formation. In germinal centers involved in maintaining B-cell tolerance and in preventing autoimmunity. In mast cells negatively regulates high affinity immunoglobulin epsilon receptor signaling; independent of SH2D1A and SH2D1B but implicating FES and PTPN6/SHP-1. In macrophages enhances LPS-induced MAPK phosphorylation and NF-kappaB activation and modulates LPS-induced cytokine secretion; involving ITSM 2. Positively regulates macroautophagy in primary dendritic cells via stabilization of IRF8; inhibits TRIM21-mediated proteasomal degradation of IRF8.
基因功能參考文獻：
1. Results show that CD84 expressed on CLL cells interact with CD84 expressed on cells in their microenvironment, inducing cell survival in both sides. PMID: 27452524
2. up-regulated in Kawasaki disease arteriopathy PMID: 24635044
3. data show that overexpression of CD84 in CLL is an important survival mechanism that appears to be an early event in the pathogenesis of the disease PMID: 23435417
4. These findings support a model in which CD84 genotypes and/or expression may serve as a useful biomarker for response to etanercept treatment in RA patients of European ancestry PMID: 23555300
5. CD84 is highly expressed in mast cells and that it contributes to the regulation of FcepsilonRI signaling PMID: 22068234
6. CD84 enhances proliferation of human activated T cells by a Src homology 2 domain-containing cytoplasmic adaptor protein SLAM-associated protein (SAP)-independent mechanism. PMID: 12928397
7. The structure of CD84 provides insight into SLAM family function. Point mutations were studied. PMID: 17563375
8. These data suggest that CD84 may play a role in modulating Fc epsilon RI-mediated signaling in mast cells. PMID: 18243321
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亞細胞定位：

Cell membrane; Single-pass type I membrane protein.
組織特異性：

Predominantly expressed in hematopoietic tissues, such as lymph node, spleen and peripheral leukocytes. Expressed in macrophages, B-cells, monocytes, platelets, thymocytes, T-cells and dendritic cells. Highly expressed in memory T-cells. Expressed in mast
數據庫鏈接：

HGNC: 1704

OMIM: 604513

KEGG: hsa:8832

STRING: 9606.ENSP00000312367

UniGene: Hs.398093

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