CD5 Antibody
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中文名稱：CD5兔多克隆抗體
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貨號：CSB-PA001470
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規格：￥1090
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圖片：
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Western Blot analysis of 293 cells using CD5 Polyclonal Antibody
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其他：
產品詳情
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Uniprot No.：
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基因名：
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別名：CD5; LEU1; T-cell surface glycoprotein CD5; Lymphocyte antigen T1/Leu-1; CD antigen CD5
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宿主：Rabbit
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反應種屬：Human,Mouse,Rat
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免疫原：Synthesized peptide derived from Human CD5 around the non-phosphorylation site of Y453.
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
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抗體亞型：IgG
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純化方式：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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產品提供形式：Liquid
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應用范圍：WB, ELISA
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推薦稀釋比：
Application Recommended Dilution WB 1:500-1:2000 ELISA 1:20000 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：May act as a receptor in regulating T-cell proliferation.
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基因功能參考文獻：
- the present results support the notion that CD5 is not only a phenotypic marker but a relevant player in CLL cell biology, as demonstrated by the influence of germline-defined functional CD5 variants on CLL outcome. PMID: 26991857
- ZAP70 is the only gene that is differentially expressed in CD5-high and CD5-low normal B-lymphocytes, confirming the key role of Zap-70 tyrosine kinase in BCR signaling alterations in B-CLL. PMID: 29125235
- The high CD5 plasma levels in patients with severe ASD, probably indicated that CD5 might be implicated in the physiology of autism. However, this finding should be treated with caution until further investigations are performed with larger populations to determine whether the increase in plasma CD5 levels is a mere consequence of autism or it plays a pathogenic role in the disease. PMID: 28406773
- A CD34-negative MYC-rearranged B-lymphoblastic lymphoma aberrantly expresses CD3 and CD5. PMID: 28280048
- study provides understanding of the regulation of CD5 expression on leukaemic T cells, and may help in understanding the molecular mechanism of CD5 down-regulation. PMID: 28752543
- CD5 transcription is increased, leading to the production of three mRNA isoforms by APA, all contributing for protein production, at different levels. PTBP1 binds in the vicinity of pA1, leading to an increase in mRNA levels and miR-204 targets the longer CD5 mRNA. PMID: 27005442
- High CD5 expression is associated with lymphoma in Waldeyer ring. PMID: 27616053
- Thus, trans-signaling of IL-6 can only occur via sIL-6R, but not sCD5. PMID: 28159554
- The major proportion of CD5(low) B cells in patients are leukemic, thus identifying CD5(low) B cells as an important component of CLL, with implications for CLL pathogenesis, clinical monitoring, and the development of anti-CD5-directed therapies. PMID: 27693386
- the CD5 Pro224-Ala471 haplotype in homozygosis improved melanoma survival in the entire set of patients (HR = 0.27, 95% CI 0.11-0.67, Adj. p = 0.005). These findings highlight the relevance of genetic variability in immune-related genes for clinical outcome in melanoma. PMID: 27169428
- R-EPOCH therapy does not seem to impact the known poorer prognosis of patients with de novo CD5+ diffuse large B-cell lymphoma , and CD5 expression was still an independent prognostic factor in R-EPOCH-treated patients with diffuse large B-cell lymphoma. PMID: 28039906
- CD5+B lymphocytes were increased and activated in autoimmune hemolytic anemia patients. PMID: 26968550
- This study confirms the poor prognosis of de novo CD5+ DLBCL in a large multi-center cohort despite initial rituximab-containing chemotherapy and suggests that stem cell transplantation fails to salvage the majority of these patients. PMID: 26800311
- 5.2 % were positive for CD5 and 5.7 % positive for epstein-Barr virus encoded RNA PMID: 26369546
- CD5 polymorphisms are associated with systemic lupus erythematosus. PMID: 25402503
- three tyrosine-based domains within CD5 cytoplasmic tail promote T-cell survival through non-overlapping mechanisms PMID: 26363459
- A case of mantle cell lymphoma with a unique pattern of CD5 negative to positive expression switching in relapse. PMID: 24166616
- useful in distinguishing thymic carcinoma from poorly differentiated lung carcinoma PMID: 23958552
- Data show that the proportion of CD5+ B cells at 1 mo of age is inversely correlated to total IgG levels at 18 and 36 mo of age. PMID: 24928995
- down-regulation of CD5 on activated CD8(+) T cells may serve as a useful marker of dysregulated T cell activation and proliferation in FHL2. PMID: 24051121
- CD5 expression in nodal marginal zone lymphoma correlates with a higher frequency of dissemination, but patients have an indolent clinical course and excellent overall survival. PMID: 24124149
- Our results indicate that CD5(+) B cell subsets might be associated with pathogenesis of SPMS. PMID: 22732449
- Functional CD5-dependent casein kinase 2 signaling is necessary in a CD5 knock-in mouse for efficient differentiation of naive CD4+ T cells into T helper (Th)2 and Th17 cells, but not Th1-type cells. PMID: 22904299
- Case Report: CD5-positive marginal zone B-cell lymphoma of the mucosa-associated lymphoid tissue (MALT) of the lung. PMID: 22333190
- Our results show that CD5 expression is rare in MALT lymphoma, and is often associated with nongastric disease and an increased tendency to present with disseminated disease. PMID: 22406370
- Hepatitis C virus infection of human T lymphocytes is mediated by CD5. PMID: 22278227
- The primary carcinoma showing thymus-like elements of the thyroid frequently expresses KIT and CD5 proteins. PMID: 21835435
- Alternative costimulation via CD5, rather than classic costimulation via CD28, primes naive T cells for stable Th17 development through promoting the expression of IL-23R. PMID: 21926348
- Post-thymic regulation of CD5 levels in human memory T cells is inversely associated with the strength of responsiveness to interleukin-15. PMID: 21539877
- immunological significance of CD19 for the IL-10 production by CD5(+) B cells PMID: 21786452
- Case Report: describe the recurrence of CD5 positive MALT lymphoma in the oral cavity and compared the immunohistochemical expressions of CD5, lambda, and kappa between the primary and recurrent tumors. PMID: 21892966
- CD5 glycoprotein-mediated T cell inhibition dependent on inhibitory phosphorylation of Fyn kinase PMID: 21757751
- Conclude that high percentages of CD5+B cells independently associate with increased risk of early conversion to multiple sclerosis in clinically isolated syndrome patients. PMID: 21436320
- Data show that CD5 expression is associated with NFAT2 activity and mildly STAT3 activity, indicating that CD5 controls IL-10 secretion. PMID: 21398617
- full-length protein variant, encoded by E1A-cd5, translocates the phosphatase SHP-1 to the vicinity of the B-cell receptor, raises its threshold, and thereby limits the response of autoreactive B cells [review] PMID: 21395509
- CD5-positive splenic marginal zone lymphoma may be related to memory B-cell neoplasm or plasma cell differentiation PMID: 21123968
- Type B3 thymic epithelial tumor in an adolescent detected by immunohistochemical staining for CD5, CD99, and KIT (CD117): a case report. PMID: 19901887
- CD5-negative regulation of B cell receptor signaling originates from tyrosine residue Y429 outside an immunoreceptor tyrosine-based inhibitory motif PMID: 11751967
- Origins and functions of B-1 cells with notes on the role of CD5. Review. PMID: 11861604
- multiple somatic mutations in human cancers. the value of the CD5 microsatellite as a marker for instability in different tumor types, particularly in B-cell leukemia and lymphoma. PMID: 11869933
- CD5 supports the survival of B cells by stimulating IL-10 production and by concurrently exerting negative feedback on BCR-induced signaling events that can promote cell death. PMID: 12393419
- CD5-negative, CD10-negative small B-cell leukemia: variant of chronic lymphocytic leukemia or a distinct entity PMID: 12447961
- CD5 is rapidly recruited at the immunological synapse (IS) and lowers the T cell response elicited by antigen presentation by targeting downstream signaling events without affecting IS formation. PMID: 12707340
- The CD5+ diffuse large-B-cell lymphoma (DLBCL) constitutes a disease category distinct from that of CD5- DLBCL and other CD5+ malignancies. PMID: 14603444
- the 5'-flanking region of human CD5 is transcriptionally active in T cells, and Ets transcription factors in conjunction with other regulatory elements are responsible for constitutive and tissue-specific CD5 expression PMID: 15187131
- Overexpression in these cells indicates diseaase progression in B=cell leukemia patients. PMID: 15549146
- CD5 is associated with receptor revision in activated mature B cells and likely to promote expression of suitable immunoglobulin gene receptors capable of initiating the germinal center reaction. PMID: 15843554
- The polymorphic CD5 promoter is associated with increased susceptibility to B-cell chronic lymphocytic leukemia and mantle cell lymphoma. PMID: 15981803
- balance between the 2 alternative exons 1 might be central to the regulation of membrane CD5 in human B cells PMID: 15998834
- analysis of CD5-positive diffuse large B-cell lymphoma with the unusual phenotype of cytoplasmic CD20 (+), surface CD20 (-) [case report] PMID: 16923582
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亞細胞定位：Cell membrane; Single-pass type I membrane protein.
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