CCL15 Antibody
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中文名稱：CCL15兔多克隆抗體
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貨號：CSB-PA784761
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規格：￥1090
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圖片：
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Immunohistochemical analysis of paraffin-embedded human-liver, antibody was diluted at 1:200
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其他：
產品詳情
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Uniprot No.：
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基因名：
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別名：C-C motif chemokine 15 antibody; C-C motif chemokine ligand 15 antibody; CC chemokine 3 antibody; CCL15 antibody; CCL15(29-92) antibody; CCL15_HUMAN antibody; Chemokine (C C motif) ligand 15 antibody; Chemokine CC-2 antibody; Chemokine CC2 antibody; HCC-2 antibody; HCC2 antibody; HMRP 2B antibody; HMRP2B antibody; Leukotactin 1 antibody; Leukotactin-1 antibody; LKN-1 antibody; LKN1 antibody; Macrophage inflammatory protein 5 antibody; MIP 1D antibody; MIP-1 delta antibody; MIP-1D antibody; MIP-5 antibody; MIP1 delta antibody; MIP1d antibody; MIP5 antibody; MRP 2B antibody; Mrp-2b antibody; Mrp2b antibody; NCC 3 antibody; NCC-3 antibody; NCC3 antibody; New CC chemokine 3 antibody; OTTHUMP00000163955 antibody; SCYA15 antibody; SCYL3 antibody; Small inducible cytokine A15 antibody; Small inducible cytokine subfamily A (Cys Cys); member 15 antibody; Small-inducible cytokine A15 antibody; SY15 antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Synthetic peptide from Human protein at AA range: 51-100
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
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純化方式：The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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產品提供形式：Liquid
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應用范圍：IHC,ELISA
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推薦稀釋比：
Application Recommended Dilution IHC IHC-p:1:50-300 ELISA 1:10000-20000 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
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靶點詳情
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功能：Chemotactic factor that attracts T-cells and monocytes, but not neutrophils, eosinophils, or B-cells. Acts mainly via CC chemokine receptor CCR1. Also binds to CCR3. CCL15(22-92), CCL15(25-92) and CCL15(29-92) are more potent chemoattractants than the small-inducible cytokine A15.
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基因功能參考文獻：
- CCL15 secreted from SMAD4-deficient xenografted human colorectal cancer cells recruited CCR1(+) cells, promoting their metastatic activities to the lung. Lung metastases from colorectal cancer patients revealed that CCL15 expression correlated with loss of SMAD4. CCL15-positive metastases recruited approximately 1.9 times more numbers of CCR1(+) cells than CCL15-negative metastases. PMID: 27492974
- CCL15 activation of CCR1 plays critical roles in hepatocellular carcinoma metastasis. PMID: 26501423
- Orthotopic animal models of HCC were established to investigate the role of CCL15 in hMSCs migration toward HCC in vivo. Both histological and flow cytometric analysis showed that significantly fewer hMSCs localized within 97H-CCL15-shRNA xenografts compared with 97H-green fluorescent protein xenografts after intravenous delivery PMID: 26763650
- Loss of SMAD4 was significantly associated with CCL15 expression. PMID: 26341919
- follicular thyroid carcinoma (FTC) might induce tumor associated macrophages (TAMs) infiltration by producing CCL15. Measurement of TAMs and CCL15 in follicular thyroid lesions may be applied clinically to differentiate FTC from follicular adenoma PMID: 26875556
- two inflammatory cytokines, MIP-1delta and MIP-3alpha, are able to increase mesenchymal stromal cells migration in vitro PMID: 25579056
- we investigated a role of CCL15 in upregulating ICAM-1 in endothelial cells PMID: 23690481
- CCL15 is elevated in human asthma and correlates with disease severity . PMID: 22092970
- Data show that Only three of these proteins EGF, PDGF-BB and MIP-1delta (CCL15) differed significantly in plasma between controls and Alzheimer's disease (AD). PMID: 22279551
- increased secretion by macrophages during Mycobacterium tuberculosis infection PMID: 20016943
- truncation of NH2-terminal amino acid residues increases agonistic potency on CC chemokine receptors 1 and 3 PMID: 11832479
- Lkn-1 activates the ERK pathway by transducing the signal through G(i)/G(o) protein, PLC, PKC delta and Ras, and it may play a role for cell proliferation, differentiation, and regulation of gene expression for other cellular processes PMID: 12759139
- These observations demonstrate that the two NF-kappaB binding sites are essential for phorbol myristate acetate-induced leukotactin-1 (Lkn-1)/CCL15 expression in human monocytes. PMID: 15179048
- CCL15(25-92) has in vitro and in vivo angiogenic activity PMID: 15251437
- alanine-aspartic acid residues preceding the first cysteine at the NH(2)-terminus are essential for the binding and biological activity of leukotactin-1 PMID: 15894113
- Compared with full-length CCL15, proteolytically processed CCL15 isoforms with N-terminal deletions display increased potency to induce calcium fluxes and chemotactic activity on monocytes and to induce adhesiveness of mononuclear cells to fibronectin. PMID: 16034099
- Transcription of the CCL15 gene is regulated by AP-1 and NF-kappaB through MEK and JNK MAPK pathways in monocytoid cells. PMID: 16364464
- Results point to an involvement of the CCL15-CCR1 axis in the pathophysiology of chronic renal failure. PMID: 16737685
- factor NF-kappaB plays an important role in regulation of LZIP expression, and LZIP expression regulates the monocyte cell migration induced by Lkn-1 PMID: 17296613
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亞細胞定位：Secreted.
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蛋白家族：Intercrine beta (chemokine CC) family
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組織特異性：Most abundant in heart, skeletal muscle and adrenal gland. Lower levels in placenta, liver, pancreas and bone marrow. CCL15(22-92), CCL15(25-92) and CCL15(29-92) are found in high levels in synovial fluids from rheumatoid patients.
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