CASP12 Antibody

文獻引用 (3) 說明書

中文名稱：

CASP12兔多克隆抗體
貨號：

CSB-PA747641LA01HU
規格：

￥440
圖片：
Western Blot
Positive WB detected in: Mouse brain tissue
All lanes: CASP12 antibody at 2.7μg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 39, 20, 30 kDa
Observed band size: 39 kDa

Immunohistochemistry of paraffin-embedded human liver tissue using CSB-PA747641LA01HU at dilution of 1:100

Immunofluorescent analysis of Hela cells using CSB-PA747641LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
其他：

產品詳情
產品評價
引用文獻
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) CASP12 Polyclonal antibody
Uniprot No.：

Q6UXS9
基因名：

CASP12
別名：

CASP 12 antibody; CASP-12 antibody; Casp12 antibody; CASP12P1 antibody; caspase 12 (gene/pseudogene) antibody; caspase 12 pseudogene 1 antibody; CASPC_HUMAN antibody; Inactive caspase-12 antibody; OTTHUMP00000207032 antibody
宿主：

Rabbit
反應種屬：

Human, Mouse
免疫原：

Recombinant Human Inactive caspase-12 protein (61-282AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，CASP12 Antibody (CSB-PA747641LA01HU)，的標記方式是Non-conjugated。對于CASP12 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA747641LB01HU	CASP12 Antibody, HRP conjugated	ELISA
FITC	CSB-PA747641LC01HU	CASP12 Antibody, FITC conjugated
Biotin	CSB-PA747641LD01HU	CASP12 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, WB, IHC, IF

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:5000
IHC	1:20-1:200
IF	1:50-1:200

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

引用文獻

A study on ER stress-induced apoptosis pathway in cervical cancer HeLa cells treated with biosynthesized gold nanoparticles MR Kamala Priya,Bulletin of the National Research Centre,2021
Glutathione Peroxidase 8 Suppression by Histone Deacetylase Inhibitors Enhances Endoplasmic Reticulum Stress and Cell Death by Oxidative Stress in Hepatocellular Carcinoma Cells HA Lee,Antioxidants,2021
Apoptotic Activity in Cervical Cancer HeLa Cell Lines Treated with Chitosan Nanoconjugated Drug Doxorubicin - as Nanocarrier for Drug Delivery Priya M R K, et al,/,2019

產品評價

靶點詳情

功能：

Has no protease activity. May reduce cytokine release in response to bacterial lipopolysaccharide during infections. Reduces activation of NF-kappa-B in response to TNF.
基因功能參考文獻：
1. Piezo1 plays an important role in the apoptosis of human osteoarthritis-derived chondrocytes through a caspase-12-dependent pathway. PMID: 28731145
2. study indicated the potential effect of Casp12 was on the activation of NF-kappaB by the degradation of IkappaBalpha in NPC cells. PMID: 28380444
3. CASP12 genotype thus does not influence the phenotype of systemic lupus erythematosus in African-Americans PMID: 26973091
4. Endoplasmic reticulum stress may be associated with apoptosis of LECs, resulting in cataract formation in diabetic patients. PMID: 27130368
5. Endoplasmic reticulum stress related factor ATF6 and caspase-12 trigger apoptosis in neonatal hypoxic-ischemic encephalopathy. PMID: 26261584
6. Expression of caspase-12 was linked to decreased systemic and adipose tissue inflammation in a cohort of African American obese children. PMID: 26582949
7. We found that RNA interference-induced Caspase-12 silencing increased NOD1, hBD1 and hBD2 expression PMID: 25503380
8. conclude that the functional CASP12L allele is not a marker for susceptibility and/or severity of CAP PMID: 24586588
9. EtOH-induced activation of caspase-12 could be one of the underlying mechanisms of hepatocyte apoptosis. PMID: 24224909
10. Distribution of CASP12 alleles (#rs497116) in African-Americans (AA) with rheumatoid arthritis (RA). There was no difference in the overall distribution of genotypes within AA with RA, but homozygous patients had lower baseline joint-narrowing scores. PMID: 24515649
11. CASPASE-12 does not influence the susceptibility to Candida sepsis, nor has any effect on the serum cytokine concentrations in Candida sepsis patients during the course of infection. PMID: 21706251
12. examines the role that CASP12 plays in down-regulating inflammation, we hypothesize that pathogens which exploit the inflammatory response are restrained by an active CASP12 gene product PMID: 21872999
13. caspase 12 has acquired deleterious mutations PMID: 12054529
14. Pathways involving this enzyme are involved in a neurodegenerative disease in vivo, and thus offer novel potential targets for the treatment of prion disorders. PMID: 14532116
15. Na/Ca exchanger overexpression activates caspase-12 PMID: 15033764
16. Csp12-L attenuates the inflammatory and innate immune response to endotoxins and in doing so may constitute a risk factor for developing sepsis PMID: 15129283
17. Observational study of genotype prevalence. (HuGE Navigator) PMID: 16917906
18. The activation of caspase-9 and depolarization of mitochondrial membrane potential were induced by BIK, which were decreased concomitant with caspase-12 silenced. PMID: 17574210
19. proteolytic activity of caspase-12 is confined to its own proenzyme PMID: 18332441
20. hRPE cells express a high level of caspase-12S. The regulated expression of caspase-12S suggests that this caspase recruitment domain (CARD)-only protein may be an endogenous dominant negative regulator that modulates inflammatory responses in hRPE cells. PMID: 18791174
21. estrogen-mediated inhibition of Csp-12L expression is a built-in mechanism that has evolved to protect females from Listeria monocytogenes infection. PMID: 19447924
22. the NOD2/RIP2 pathway has a role in recognition of Yersinia, but caspase-12 does not modulate innate host defense against Y. pestis PMID: 19721713
23. The calcium-calpain-caspase-12-caspase-3 cascade is altered in F508del-CFTR expressing cells. PMID: 20041182
24. Reactive oxygen species promote caspase-12 expression and tubular apoptosis in diabetic nephropathy. PMID: 20299359
25. Observational study of gene-disease association. (HuGE Navigator) PMID: 20299368
26. Observational study of gene-disease association. (HuGE Navigator) PMID: 20423816
27. Observational study of gene-disease association. (HuGE Navigator) PMID: 20577092
28. Constitutively active forms of caspase-12 (rev-Deltapro1 and rev-Deltapro2) could induce cell death in cells transfected with the corresponding expression vectors. PMID: 20646990
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蛋白家族：

Peptidase C14A family
組織特異性：

Detected in heart, kidney, liver, lung, pancreas, small intestine, spleen, stomach, thymus and testis.
數據庫鏈接：

HGNC: 19004

OMIM: 608633

KEGG: hsa:100506742

STRING: 9606.ENSP00000424038

UniGene: Hs.476989

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