CARD10 Antibody
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中文名稱：CARD10兔多克隆抗體
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貨號：CSB-PA001213
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規格：￥1090
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圖片：
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Western Blot analysis of 293 cells using CARD 10 Polyclonal Antibody
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其他：
產品詳情
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Uniprot No.：
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基因名：
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別名：Bcl10 binding protein and activator of NFKB antibody; BIMP1 antibody; CAR10_HUMAN antibody; CARD 10 antibody; CARD containing MAGUK 3 protein antibody; CARD-containing MAGUK 3 antibody; CARD-containing MAGUK protein 3 antibody; CARD10 antibody; Carma 3 antibody; CARMA3 antibody; Caspase Recruitment Domain family member 10 antibody; Caspase recruitment domain-containing protein 10 antibody
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宿主：Rabbit
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反應種屬：Human,Mouse
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免疫原：Synthesized peptide derived from the Internal region of Human CARD 10.
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
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抗體亞型：IgG
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純化方式：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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產品提供形式：Liquid
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應用范圍：WB, IHC, IF, ELISA
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推薦稀釋比：
Application Recommended Dilution WB 1:500-1:2000 IHC 1:100-1:300 IF 1:200-1:1000 ELISA 1:10000 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Activates NF-kappa-B via BCL10 and IKK.
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基因功能參考文獻：
- The results suggest that the involvement of CARMA3 in DNA damage-induced NF-kappaB is through the recruitment of TRAF6. PMID: 28717989
- Card10 polymorphisms may not be linked with psoriasis vulgaris in the southern Han Chinese population. PMID: 28301668
- Data indicate no association between caspase recruitment domain family, member 10 protein (CARD10) polymorphism rs6000782 and type 1 autoimmune hepatitis (AIH) in a Japanese population. PMID: 26652023
- Findings indicate that CARMA3 may suppress the activation of the P38 MAPK signaling pathway to regulate invasion, migration and apoptosis of lung cancer cells by activating NF-small ka, CyrillicB (P65) in the nucleus. PMID: 26526492
- miR-24 inhibited cell proliferation, invasion and epithelial to mesenchymal transition in bladder cancer cells by downregulation of CARMA3 PMID: 26252200
- The study identified the DEP domain-containing protein DEPDC7 as cellular binding partner of CARMA2 and CARMA3 proteins. PMID: 25541973
- A novel mechanism of CARMA3 in lung cancer stemness and metastasis through the negative regulation of NME2 was identified. PMID: 25906011
- CARMA3 regulates the ovarian cancer cell proliferation, cell cycle progression, and chemoresistance. PMID: 24833094
- CARMA3 is overexpressed in pancreatic cancer and regulates malignant cell growth, invasion, and NF-kappaB signaling, which was dependent on its association with Bcl10. PMID: 24633921
- CARMA3 is overexpressed in bladder cancer and regulates malignant cell growth and NF-kappaB signaling. PMID: 24443255
- Genetic variation within PARP1 and CARD10 was associated with rate of hippocampal neurodegeneration in APOE e3/e3 patients. PMID: 23608917
- CARD10 may be involved in hepatic carcinogenesis associated with hepatitis C in Egyptian patients. PMID: 24018495
- overexpression of CARMA3 in human glioma and its correlation with tumor grade. PMID: 23893382
- Data show that CARMA3 may serve as a novel and prognostic marker for renal cell carcinoma (RCC) and play a role during the development and progression of the disease. PMID: 23771851
- CARMA3 facilitates proliferation and inhibits apoptosis through nuclear factor-kappaB signaling. PMID: 23708960
- this study found that CARMA3 is overexpressed in colon cancers and contributes to malignant cell growth by facilitating cell cycle progression through NF-kappaB mediated upregulation of cyclin D1. PMID: 22884800
- The overexpression of CARMA3 was significantly correlated with TNM stage (P = 0.022) and tumor status (P = 0.013). PMID: 22615840
- Polymorphisms of ATOH7, TGFBR3 and CARD10 influence the size of optic disc area. PMID: 21307088
- Data show that CARMA3 and Bcl10 contributed to several characteristics of EGFR-associated malignancy, including proliferation, survival, migration, and invasion. PMID: 21406399
- CARMA1 and CARMA3 bind to Ikappa kinase gamma-NFkappaB in B and T lymphocytes PMID: 15184390
- Protein kinase C-CARMA3 signaling axis plays an essential role in lysophosphatidic acid-induced ovarian cancer cell in vitro invasion. PMID: 17724468
- results further define the molecular mechanisms that control activation of NF-kappaB and reveal a function for A20 in the regulation of CARMA and BCL10 activity in lymphoid and non-lymphoid cells PMID: 18349075
- Data demonstrate that lysophosphatidic acid stimulates thymic stromal lymphopoietin and CCL20 expression in bronchial epithelial cells via CARMA3-mediated NF-kappaB activation. PMID: 18757306
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亞細胞定位：Cytoplasm.
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組織特異性：Detected in adult heart, kidney and liver; lower levels in intestine, placenta, muscle and lung. Also found in fetal lung, liver and kidney.
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