CAPZA1 Antibody

文獻引用 (2) 說明書

中文名稱：

CAPZA1兔多克隆抗體
貨號：

CSB-PA004510LA01HU
規格：

￥440
圖片：
Western Blot
Positive WB detected in: THP-1 whole cell lysate
All lanes: CAPZA1 antibody at 3µg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 33 kDa
Observed band size: 33 kDa

Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA004510LA01HU at dilution of 1:100

Immunofluorescent analysis of HepG2 cells using CSB-PA004510LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
其他：

產品詳情
產品評價
引用文獻
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) CAPZA1 Polyclonal antibody
Uniprot No.：

P52907
基因名：

CAPZA1
別名：

Cap Z antibody; Cappa 1 antibody; Cappa1 antibody; Capping protein (actin filament) muscle Z line alpha 1 antibody; Capping protein alpha 1 antibody; Capping protein muscle Z line alpha 1 antibody; CapZ alpha 1 antibody; CapZ alpha-1 antibody; CAPZ antibody; CAPZA 1 antibody; Capza1 antibody; CAZ 1 antibody; CAZ1 antibody; CAZA1_HUMAN antibody; F actin capping protein alpha 1 subunit antibody; F-actin-capping protein subunit alpha-1 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human F-actin-capping protein subunit alpha-1 protein (211-252AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，CAPZA1 Antibody (CSB-PA004510LA01HU)，的標記方式是Non-conjugated。對于CAPZA1 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA004510LB01HU	CAPZA1 Antibody, HRP conjugated	ELISA
FITC	CSB-PA004510LC01HU	CAPZA1 Antibody, FITC conjugated
Biotin	CSB-PA004510LD01HU	CAPZA1 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, WB, IHC, IF

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:5000
IHC	1:20-1:200
IF	1:50-1:200

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

引用文獻

Research Article Long-Read Nanopore Sequencing Identifies Mismatch Repair-Deficient Related Genes with Alternative Splicing in Colorectal Cancer H Qu,Disease markers,2022
Long-Read Nanopore Sequencing Identifies Mismatch Repair-Deficient Related Genes with Alternative Splicing in Colorectal Cancer H Qu,Disease Markers,2022

產品評價

靶點詳情

功能：

F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. May play a role in the formation of epithelial cell junctions.
基因功能參考文獻：
1. Data show that CAPZA1 inhibits EMT in hepatocellular carcinoma (HCC cells by regulating actin cytoskeleton remodeling, thereby reducing the metastatic ability of the cells. PMID: 28093067
2. Disease causing mutations in inverted formin 2 regulate its binding to G-actin, F-actin capping protein (CapZ alpha-1) and profilin 2. PMID: 26764407
3. mDia1 displaced from the barbed end by CapZ Actin Capping Protein can randomly slide along the actin filament and later return. PMID: 26566078
4. The present study suggests that CAPZA1 could be a marker of good prognosis in gastric cancer and shows that CAPZA1 is associated with decreased cancer cell migration and invasion. PMID: 23545944
5. CAPAZA1 is over expressed in malignant melanoma. PMID: 21566537
6. V-1, a protein expressed transiently during murine cerebellar development, regulates actin polymerization via interaction with capping protein PMID: 12488317
7. Cd2 antigen is linked to this protein via CMS and CIN85. PMID: 12690097
8. CKIP-1 has a role in cell morphology that depends on its interaction with actin-capping protein PMID: 16987810
9. Damaging exercise induced the expression of capZalpha, MCIP1, CARP1, DNAJB2, c-myc, and junD, each of which are likely involved in skeletal muscle growth, remodeling, and stress management. PMID: 18321953
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亞細胞定位：

Cytoplasm, cytoskeleton.
蛋白家族：

F-actin-capping protein alpha subunit family
數據庫鏈接：

HGNC: 1488

OMIM: 601580

KEGG: hsa:829

STRING: 9606.ENSP00000263168

UniGene: Hs.744974

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