CAMLG Antibody

中文名稱：

CAMLG兔多克隆抗體
貨號：

CSB-PA004475LA01HU
規格：

￥440
圖片：
Western Blot
Positive WB detected in: Jurkat whole cell lysate, HEK293 whole cell lysate, U87 whole cell lysate, SH-SY5Y whole cell lysate
All lanes: CAMLG antibody at 3µg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 33 kDa
Observed band size: 33 kDa

Immunofluorescent analysis of HepG2 cells using CSB-PA004475LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

Immunoprecipitating CAMLG in HEK293 whole cell lysate
Lane 1: Rabbit control IgG (1µg) instead of CSB-PA004475LA01HU in HEK293 whole cell lysate. For western blotting, a HRP-conjugated Protein G antibody was used as the secondary antibody (1/2000)
Lane 2: CSB-PA004475LA01HU (8µg) + HEK293 whole cell lysate (500µg)
Lane 3: HEK293 whole cell lysate (10µg)
其他：

產品詳情
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靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) CAMLG Polyclonal antibody
Uniprot No.：

P49069
基因名：

CAMLG
別名：

CAMLG antibody; CAML antibody; Calcium signal-modulating cyclophilin ligand antibody; CAML antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Calcium signal-modulating cyclophilin ligand protein (1-189AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，CAMLG Antibody (CSB-PA004475LA01HU)，的標記方式是Non-conjugated。對于CAMLG Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA004475LB01HU	CAMLG Antibody, HRP conjugated	ELISA
FITC	CSB-PA004475LC01HU	CAMLG Antibody, FITC conjugated
Biotin	CSB-PA004475LD01HU	CAMLG Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, WB, IF, IP

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:5000
IF	1:50-1:500
IP	1:200-1:2000

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunofluorescence (IF) Protocol
Immunoprecipitation (IP) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Together with GET1/WRB, acts as a membrane receptor for soluble GET3/TRC40, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. Required for the stability of GET1. Stimulates calcium signaling in T cells through its involvement in elevation of intracellular calcium. Essential for the survival of peripheral follicular B cells.
基因功能參考文獻：
1. Found that the calcium-modulating cyclophilin ligand (CAMLG), which is involved in Ca(2+) signaling, was the major host cell PilA binding protein. PMID: 23266901
2. Results indicate calcium-modulating cyclophilin ligand (CAML) and WRB as components of the TRC40 receptor complex and a crucial mechanism for driving ER membrane insertion of TA proteins in mammalian cells. PMID: 23041287
3. CAML was found to play a crucial role in the PRL/PRLR-dependent growth of breast cancer cells. PMID: 21128111
4. this study demonstrated that DENV manipulated the levels of CAML to subvert the apoptotic process which in turn favoured efficient virus production. PMID: 22281498
5. CAMLG was more frequently significantly overexpressed in acute myeloid leukemia patients with CD56 immunophenoytpe PMID: 12031912
6. Kaposi's sarcoma-associated herpesvirus mitochondrial K7 protein targets cellular CAML to increase the cytosolic Ca(2+) response, which consequently protects cells from mitochondrial damage and apoptosis PMID: 12388711
7. CAML is an important signal transducer for the actions of Ang II in regulating the calcineurin-NFAT pathway and the interaction of CAML with ATRAP may mediate the Ang II actions in vascular physiology PMID: 15668245
8. The intracellular C-terminus of fibrocystin interacts with CAML, a protein with an intracellular distribution that is similar to that of PKD2. PMID: 16243292
9. Binding of the MUC1 CT to CAML in human epithelial cells was confirmed by reciprocal coimmunoprecipitations, confocal microscopy, protein crosslinking, and coupled transcription/translation analyses. PMID: 19135167
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亞細胞定位：

Endoplasmic reticulum membrane; Multi-pass membrane protein.
組織特異性：

Ubiquitous. Highest levels in brain, testis and ovary.
數據庫鏈接：

HGNC: 1471

OMIM: 601118

KEGG: hsa:819

STRING: 9606.ENSP00000297156

UniGene: Hs.529846

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