CALCOCO2 Antibody
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中文名稱：CALCOCO2兔多克隆抗體
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貨號：CSB-PA004437GA01HU
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規格：￥3,900
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其他：
產品詳情
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Uniprot No.：
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基因名：
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別名：Antigen nuclear dot 52 kDa protein antibody; CACO2_HUMAN antibody; Calcium binding and coiled coil domain 2 antibody; Calcium binding and coiled coil domain containing protein 2 antibody; Calcium-binding and coiled-coil domain-containing protein 2 antibody; CALCOCO 2 antibody; CALCOCO2 antibody; MGC17318 antibody; NDP52 antibody; Nuclear domain 10 protein 52 antibody; Nuclear domain 10 protein antibody; Nuclear domain 10 protein NDP52 antibody; Nuclear domain protein 52 antibody; Nuclear dot protein 52 antibody; OTTHUMP00000218344 antibody; OTTHUMP00000218345 antibody; OTTHUMP00000218346 antibody; OTTHUMP00000218347 antibody; OTTHUMP00000218349 antibody; OTTHUMP00000218351 antibody
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宿主：Rabbit
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反應種屬：Human,Mouse
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免疫原：Human CALCOCO2
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免疫原種屬：Homo sapiens (Human)
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抗體亞型：IgG
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純化方式：Antigen Affinity Purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
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產品提供形式：Liquid
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應用范圍：ELISA,WB,IHC
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
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靶點詳情
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功能：Xenophagy-specific receptor required for autophagy-mediated intracellular bacteria degradation. Acts as an effector protein of galectin-sensed membrane damage that restricts the proliferation of infecting pathogens such as Salmonella typhimurium upon entry into the cytosol by targeting LGALS8-associated bacteria for autophagy. Initially orchestrates bacteria targeting to autophagosomes and subsequently ensures pathogen degradation by regulating pathogen-containing autophagosome maturation. Bacteria targeting to autophagosomes relies on its interaction with MAP1LC3A, MAP1LC3B and/or GABARAPL2, whereas regulation of pathogen-containing autophagosome maturation requires the interaction with MAP3LC3C. May play a role in ruffle formation and actin cytoskeleton organization and seems to negatively regulate constitutive secretion.
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基因功能參考文獻：
- Backfolding of MVI regulates its ability to bind DNA and that a putative transcription co-activator NDP52 relieves the auto-inhibition of MVI to enable DNA binding. Additionally, we show that the MVI-NDP52 complex binds RNAPII, which is critical for transcription, and that depletion of NDP52 or MVI reduces steady-state mRNA levels. PMID: 29187741
- findings reveal a negative feedback loop of RLR signaling generated by Tetherin-MARCH8-MAVS-NDP52 axis and provide insights into a better understanding of the crosstalk between selective autophagy and optimal deactivation of type I IFN signaling. PMID: 28965816
- The authors propose that Rab35-GTP is a critical regulator of autophagy through recruiting autophagy receptor NDP52. PMID: 28848034
- The authors identify calcium-binding and coiled-coil domain 2 (CALCOCO2, also known as NDP52) as a binding partner of influenza A virus PB1-F2. PMID: 28613140
- Presence of the NDP52 rs2303015 minor variant increases the risk for spontaneous bacterial peritonitis in patients with alcoholic cirrhosis. PMID: 26493630
- insight into how CALCOCO2 targets ubiquitin-decorated pathogens for autophagic degradations PMID: 26506893
- control retrotransposon insertion in the genome PMID: 25366815
- These data show that NDP52 promotes the maturation of autophagosomes via its interaction with LC3A, LC3B, and/or GABARAPL2 through a distinct LC3-interacting region, and with MYOSIN VI. PMID: 25771791
- data support a model in which non-ND10 resident Sp100 acts as a negative regulator of polycomb repressive complex-2 (PRC2) recruitment, and suggest that KSHV may actively escape ND10 silencing mechanisms to promote establishment of latent chromatin. PMID: 25033267
- the role of ORF75 in the antagonization of ND10-mediated intrinsic immunity PMID: 24453968
- Dimeric NDP52 forms a ternary complex with two monomeric galectin-8 molecules as well as two LC3C molecules PMID: 23511477
- The missense SNP rs2303015 (Val248Ala) in the NDP52 was associated with Crohn's disease. PMID: 23624108
- Data indicate that the binding site in galectin-8 is essential for the recruitment of the autophagy receptor NDP52 to cytosol-exposed Salmonella Typhimurium. PMID: 23386746
- Autophagy of Tax1bp1/Ndp52 promotes non-canonical NF-kappaB signalling. PMID: 23209807
- Data show that the selectivity of the autophagy receptor NDP52 for LC3C is crucial for innate immunity since cells lacking either protein cannot protect their PMID: 23022382
- Data show that the miRNA-processing enzyme, DICER and the main miRNA effector, AGO2, are targeted for degradation as miRNA-free entities PMID: 23143396
- a selective autophagic mechanism mediated by NDP52 that works downstream of TRIF-TRAF6. PMID: 21964925
- p62 and NDP52 act cooperatively to drive efficient antibacterial autophagy by targeting the protein complexes they coordinate to distinct microdomains associated with bacteria PMID: 21079414
- p62 and NDP52 proteins target intracytosolic Shigella and Listeria to different autophagy pathways. PMID: 21646350
- ND10 and ND10 components might be important defensive factors against the CMV cross-species infection PMID: 21552525
- interacts with ICP4 regulatory protein of HSV-1 during early stage of infection PMID: 14747555
- NDP52 was identified as a myosin VI binding protein; results suggest that myosin VI-T6BP-NDP52 complexes may play a role in coordinating cytokine signalling and membrane transport pathways with actin filament organisation and cell adhesion PMID: 17635994
- NDP52 recognizes ubiquitin-coated Salmonella enterica and recruits TBK1. PMID: 19820708
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亞細胞定位：Cytoplasm, perinuclear region. Cytoplasm, cytoskeleton. Cytoplasmic vesicle, autophagosome membrane; Peripheral membrane protein.
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蛋白家族：CALCOCO family
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組織特異性：Expressed in all tissues tested with highest expression in skeletal muscle and lowest in brain.
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數據庫鏈接：
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