CACNB2 Antibody

中文名稱：

CACNB2兔多克隆抗體
貨號(hào)：

CSB-PA804482LA01HU
規(guī)格：

￥440
圖片：
IHC image of CSB-PA804482LA01HU diluted at 1:500 and staining in paraffin-embedded human liver cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

Immunofluorescence staining of A549 cells with CSB-PA804482LA01HU at 1:166, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
其他：

產(chǎn)品詳情
產(chǎn)品評(píng)價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情

產(chǎn)品詳情

產(chǎn)品名稱：

Rabbit anti-Homo sapiens (Human) CACNB2 Polyclonal antibody
Uniprot No.：

Q08289
基因名：

CACNB2
別名：

AW060387 antibody; Ca(V) beta 2 antibody; CAB2 antibody; CACB2_HUMAN antibody; CACNB2 antibody; CACNLB2 antibody; Calcium channel voltage dependent subunit beta 2 antibody; Calcium channel voltage-dependent subunit beta 2 antibody; Calcium channel; voltage dependent; beta 2 subunit antibody; CAVB2 antibody; Cavbeta2 antibody; Cchb2 antibody; FLJ23743 antibody; Lambert Eaton Myasthenic syndrome antigen antibody; Lambert Eaton myasthenic syndrome antigen B antibody; Lambert-Eaton myasthenic syndrome antigen B antibody; MGC129334 antibody; MGC129335 antibody; Myasthenic (Lambert Eaton) syndrome antigen B antibody; Myasthenic syndrome antigen B antibody; MYSB antibody; Voltage dependent L type calcium channel subunit beta 2 antibody; Voltage-dependent L-type calcium channel subunit beta-2 antibody
宿主：

Rabbit
反應(yīng)種屬：

Human
免疫原：

Recombinant Human Voltage-dependent L-type calcium channel subunit beta-2 protein (490-637AA)
免疫原種屬：

Homo sapiens (Human)

標(biāo)記方式：

Non-conjugated

本頁面中的產(chǎn)品，CACNB2 Antibody (CSB-PA804482LA01HU)，的標(biāo)記方式是Non-conjugated。對(duì)于CACNB2 Antibody，我們還提供其他標(biāo)記。見下表：

標(biāo)記方式	貨號(hào)	產(chǎn)品名稱	應(yīng)用
HRP	CSB-PA804482LB01HU	CACNB2 Antibody, HRP conjugated	ELISA
FITC	CSB-PA804482LC01HU	CACNB2 Antibody, FITC conjugated
Biotin	CSB-PA804482LD01HU	CACNB2 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

ELISA, IHC, IF

推薦稀釋比：

Application	Recommended Dilution
IHC	1:500-1:1000
IF	1:50-1:200

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
儲(chǔ)存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

功能：

The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting.
基因功能參考文獻(xiàn)：
1. Data show that an indispensable beta-subunit of the voltage-gated Ca(2+) channel Cav1.2 interaction with H-Ras is independently of Ca(2+) flux, suggesting the regulatory role of beta2 in transcriptional activation via the ERK/CREB pathway. PMID: 30150369
2. Our study shows that palmitoylation of CaVbeta2a is necessary for CaValpha1 trafficking to the plasma membrane. However, excessive number of palmitoylated CaVbeta2a leads to Ca(2+) overload and beta cell death. PMID: 28739256
3. Study showed that CACNB2 is a possible candidate hypertrophy-modifying gene contributing to disease variability of MYBPC3-associated familial hypertrophic cardiomyopathy PMID: 28614222
4. Five serious mental disorders and three major cardiovascular diseases have recently been linked to the CACNB2 gene coding for the Cavbeta2 subunits PMID: 25966706
5. ADM genotype AA was associated with the highest values of systolic and diastolic blood pressure (BP), while CACNB2 genotype CC carriers had the highest values of diastolic BP in childhood. PMID: 25313554
6. In the gene-based analysis, CACNB2 and CTCF showed the strongest evidence for association with schizophrenia in both the present samples and in those of the Psychiatric Genetics Consortium datasets. PMID: 24901509
7. Three rare missense mutations of CACNB2 (G167S, S197F, and F240L) found in Autism Spectrum Disorders (ASD)-affected families, are reported. PMID: 24752249
8. Association of the SNP rs2932538 in MOV10 and SNP rs4373814 in CACNB2 with an increased risk of hypertension in a Chinese Han population. PMID: 24338417
9. Genetic variations in CYP17A1, CACNB2 and PLEKHA7 were related to blood pressure traits and/or hypertension in Chinese She population. PMID: 21963141
10. Genetic testing reveals disease-causing mutations in depolarizing sodium (SCN5A) or calcium (CaCNB2b) channels in 5 infants with rapid ventricular tachycardia, conduction abnormalities, and Brugada-like syndrome. PMID: 22090166
11. This study provided that cacnb2 are associated with Bipolar I in the Han Chinese population. PMID: 20386566
12. that genetic variation within CACNB2 may influence treatment-related outcomes in high-risk patients with hypertension. PMID: 21156931
13. CACNB2 is a possible novel early repolarization syndrome susceptibility gene. PMID: 20817017
14. We also identified a novel polymorphism (D601E) in CACNB2b that slowed inactivation of L-type calcium current (I(Ca,L)), significantly increased total charge. Slowed conduction was present. PMID: 20025708
15. Functional properties of the CaV1.2 calcium channel activated by calmodulin in the absence of alpha2delta subunits. PMID: 19106618
16. CACNB2 SNPs show genotypic association with Alzheimer disease. PMID: 19241460
17. The first Brugada syndrome mutation in CaCNB2b resulting in accelerated inactivation of L-type calcium channel current, is reported. PMID: 19358333
顯示更多

收起更多
相關(guān)疾病：

Brugada syndrome 4 (BRGDA4)
亞細(xì)胞定位：

Cell membrane, sarcolemma; Peripheral membrane protein; Cytoplasmic side.
蛋白家族：

Calcium channel beta subunit family
組織特異性：

Expressed in all tissues.
數(shù)據(jù)庫鏈接：

HGNC: 1402

OMIM: 600003

KEGG: hsa:783

STRING: 9606.ENSP00000320025

UniGene: Hs.59093

Most popular with customers

YWHAG Recombinant Monoclonal Antibody

Applications: ELISA, WB, IHC

Species Reactivity: Human
YWHAB Recombinant Monoclonal Antibody

Applications: ELISA, WB, IHC, IF, FC

Species Reactivity: Human, Mouse, Rat
Phospho-YAP1 (S127) Recombinant Monoclonal Antibody

Applications: ELISA, WB, IHC

Species Reactivity: Human
XRCC5 Recombinant Monoclonal Antibody

Applications: ELISA, WB, IHC, IF

Species Reactivity: Human
XPNPEP1 Recombinant Monoclonal Antibody

Applications: ELISA, IHC, FC

Species Reactivity: Human
XDH Recombinant Monoclonal Antibody

Applications: ELISA, WB, IHC

Species Reactivity: Human
WT1 Recombinant Monoclonal Antibody

Applications: ELISA, WB, IHC

Species Reactivity: Human
WDR5 Recombinant Monoclonal Antibody

Applications: ELISA, IHC, FC

Species Reactivity: Human