CACNA1E Antibody

說明書

中文名稱：

CACNA1E兔多克隆抗體
貨號：

CSB-PA942999
規格：

￥1100
圖片：
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA942999(CACNA1E Antibody) at dilution 1/15, on the right is treated with synthetic peptide. (Original magnification: ×200)

The image on the left is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using CSB-PA942999(CACNA1E Antibody) at dilution 1/15, on the right is treated with synthetic peptide. (Original magnification: ×200)
其他：

產品詳情
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靶點詳情

產品詳情

Uniprot No.：

Q15878
基因名：

CACNA1E
別名：

alpha-1 polypeptide antibody; BII antibody; Brain calcium channel II antibody; CAC 1E antibody; CAC1E antibody; CAC1E_HUMAN antibody; CACH 6 antibody; CACH6 antibody; CACNA1E antibody; Cacnl1 a6 antibody; CACNL1A6 antibody; Calcium channel antibody; Calcium channel; L type; alpha 1 polypeptide; isoform 6 antibody; calcium channel; R type antibody; Cav 2.3 antibody; Cchra 1 antibody; Cchra1 antibody; isoform 6 antibody; L type antibody; Voltage dependent R type calcium channel subunit alpha 1E antibody; Voltage gated calcium channel subunit alpha Cav2.3 antibody; Voltage-dependent R-type calcium channel subunit alpha-1E antibody; Voltage-gated calcium channel subunit alpha Cav2.3 antibody
宿主：

Rabbit
反應種屬：

Human,Mouse,Rat
免疫原：

Synthetic peptide of Human CACNA1E
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

Antigen affinity purification
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
產品提供形式：

Liquid
應用范圍：

ELISA,IHC

推薦稀釋比：

Application	Recommended Dilution
ELISA	1:1000-1:2000
IHC	1:25-1:100

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells. They are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1E gives rise to R-type calcium currents. R-type calcium channels belong to the 'high-voltage activated' (HVA) group and are blocked by nickel. They are however insensitive to dihydropyridines (DHP). Calcium channels containing alpha-1E subunit could be involved in the modulation of firing patterns of neurons which is important for information processing.
基因功能參考文獻：
1. This study identified a polymorphism in exon 20 of the CACNA1E gene (Asp859Glu - rs35737760) that is more prevalent in hemiplegic and brain stem aura migraine. PMID: 28573794
2. Carriers of the minor G allele of the rs3845446 SNP exhibited enhanced pain-related phenotypes after gastrointestinal surgery. The pain-related phenotypes of carriers of the minor allele of this SNP after gastrointestinal surgery were opposite to such phenotypes after orthognathic surgery. PMID: 27480382
3. Data suggest that, in vascular smooth muscle cells, increase in cytosolic endothelin-1 (EDN1) induces sustained increase in nuclear Ca2+ via stimulation of R-type calcium channel (CACNA1E) present at the nuclear membrane. PMID: 25741585
4. CACNA1E gene single nucleotide polymorphisms may be involved in fentanyl sensitivity. PMID: 23940630
5. The C-terminus of human Ca(v)2.3 voltage-gated calcium channel interacts with alternatively spliced calmodulin-2 expressed in two human cell lines PMID: 22633975
6. quartet of leucine residues in the guanylate kinase domain of CaVbeta determines the plasma membrane density of the CaV2.3 channel. PMID: 22846999
7. CACNA1E variants affect beta cell function in patients with newly diagnosed type 2 diabetes. PMID: 22427875
8. the II-III loop of the Ca(v)2.3 calcium channel binds APLP1 and that this binding promotes internalization of the channel PMID: 22178872
9. Ca(v)2.3 Ca2+ channel interacts with the G1-subunit of V-ATPase. PMID: 21691059
10. Lack of high-voltage activated Cav2.3 channels results in a marked decrease in the sensitivity of transgenic animals to gamma-butyrolactone-induced absence epilepsy. PMID: 21482359
11. Swapping the I-II intracellular linker between L-type CaV1.2 and R-type CaV2.3 high-voltage gated calcium channels exchanges activation attributes. PMID: 20026913
12. Review discusses the roles of Cav2.3-containing E-type Ca2+ channels which exhibit several subunit-specific features, trigger exocytosis and are also involved in long-term potentiation. PMID: 15845089
13. Full-length RGS3, RGS3T, and the core domain of RGS3 were equally effective in antagonizing inhibition of Ca(V)2.3 through M(2)R. PMID: 16855219
14. Neurokinin 1 receptorsmodulate CaV2.3 using three different signaling mechanisms: a fast inhibition mediated by Gbeta gamma, a slow inhibition mediated by Galpha(q/11), and a slow stimulation mediated by protein kinases C. PMID: 17050807
15. Amplification and overexpression of CACNA1E correlates with relapse in favorable histology Wilms' tumors. PMID: 17189400
16. analysis of a three-dimensional homology model of Ca(V)2.3 based upon Kv1.2 where hydrophobic residues at positions facing Val(1720) in IS6, IIS6, and IIIS6 play a critical role in stabilizing the closed state in Ca(V)2.3 PMID: 17660294
17. A functional variant in CACNA1E contributes to type 2 diabetes susceptibility in Pima indians by affecting insulin action. PMID: 17720895
18. Genetic variation in the CACNA1E gene contributes to an increased risk of the development of type 2 diabetes by reducing insulin secretion. PMID: 17934712
19. These findings strongly suggest that both H179 and H183 in the IS3-IS4 loop are essential structural determinants required for nickel sensitive inhibition of the Cav2.3. PMID: 18037383
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亞細胞定位：

Membrane; Multi-pass membrane protein.
蛋白家族：

Calcium channel alpha-1 subunit (TC 1.A.1.11) family, CACNA1E subfamily
組織特異性：

Expressed in neuronal tissues and in kidney.
數據庫鏈接：

HGNC: 1392

OMIM: 601013

KEGG: hsa:777

STRING: 9606.ENSP00000356545

UniGene: Hs.437444

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