CABP1 Antibody

中文名稱：

CABP1兔多克隆抗體
貨號(hào)：

CSB-PA080285
規(guī)格：

￥1090
其他：

產(chǎn)品詳情
產(chǎn)品評(píng)價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情

產(chǎn)品詳情

Uniprot No.：

Q9NZU7
基因名：

CABP1
別名：

CABP 1 antibody; CaBP1 antibody; CABP1_HUMAN antibody; Calbrain antibody; Calcium binding protein 1 antibody; Calcium binding protein 5 antibody; Calcium-binding protein 1 antibody; Caldendrin antibody; HCALB BR antibody; HCALB_BR antibody
宿主：

Rabbit
反應(yīng)種屬：

Rat,Mouse
免疫原：

Synthetic Peptide
免疫原種屬：

Homo sapiens (Human)
標(biāo)記方式：

Non-conjugated
抗體亞型：

IgG
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

WB

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:2000

Protocols：

Western Blotting (WB) Protocol
儲(chǔ)存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

功能：

Modulates calcium-dependent activity of inositol 1,4,5-triphosphate receptors (ITPRs)(PubMed:14570872). Inhibits agonist-induced intracellular calcium signaling. Enhances inactivation and does not support calcium-dependent facilitation of voltage-dependent P/Q-type calcium channels. Causes calcium-dependent facilitation and inhibits inactivation of L-type calcium channels by binding to the same sites as calmodulin in the C-terminal domain of CACNA1C, but has an opposite effect on channel function. Suppresses the calcium-dependent inactivation of CACNA1D. Inhibits TRPC5 channels. Prevents NMDA receptor-induced cellular degeneration. Required for the normal transfer of light signals through the retina.
基因功能參考文獻(xiàn)：
1. the faster migrating Tg adduct C primarily engages the CaBP1/P5 oxidoreductase, whereas the slower migrating Tg adduct A primarily engages ERp72. PMID: 24599957
2. Present the NMR structure of full-length CaBP1 with Ca(2+) bound at the first, third, and fourth EF-hands. PMID: 21608059
3. Different kinetics of Ca-dependent binding step between caldendrin and calmodulin with AKAP79 suggest their different roles in synaptic function. PMID: 22996592
4. We demonstrate that calmodulin and caldendrin compete for a partially overlapping binding site on AKAP79 and that their binding is differentially dependent on calcium PMID: 22693956
5. CaBP1 regulates voltage-dependent inactivation and activation of Ca(V)1.2 (L-type) calcium channels PMID: 21383011
6. Structural basis for the differential effects of CaBP1 and calmodulin on Ca(V)1.2 calcium-dependent inactivation. PMID: 21134641
7. enhances inactivation, causes a depolarizing shift in the voltage dependence of activation, and does not support Ca2+-dependent facilitation of Ca(v)2.1 channels PMID: 11865310
8. CaBP1 is able to specifically regulate InsP3 receptor-mediated alterations in [Ca2+]i during agonist stimulation. PMID: 14570872
9. We describe a new role for CaBP1 in regulation of Ca2+ influx through Ca(v)1.2 (L-type) Ca2+ channels. CaBP1 interacts directly with the alpha1 subunit of Ca(v)1.2 at sites that also bind Calmodulin PMID: 15140941
10. the NT and IQ-domains of alpha(1)1.2 mediate functionally distinct interactions with CaBP1 and CaM that promote conformational alterations that either stabilize or inhibit inactivation of Ca(v)1.2. PMID: 15980432
11. NMR, microcalorimetry, and other biophysical studies that characterize Ca(2+) binding, Mg(2+) binding, and structural properties of recombinant CaBP1 are reported. PMID: 16147998
12. the importance of CaBP1s in modulating the stimulus-secretion coupling in excitable cells. PMID: 17960496
13. CaBP1 may regulate Ca2+-dependent activity of inositol 1,4,5-trisphosphate receptors by promoting structural contacts between the suppressor and core domains PMID: 19008222
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亞細(xì)胞定位：

Cytoplasm, cytoskeleton. Cytoplasm, perinuclear region. Cell membrane; Lipid-anchor; Cytoplasmic side. Golgi apparatus. Cell junction, synapse, postsynaptic density.; [Isoform L-CaBP1]: Cytoplasm, cytoskeleton.; [Isoform S-CaBP1]: Cytoplasm, cell cortex. Cell membrane; Lipid-anchor. Note=S-CaBP1 is localized at or near the plasma membrane.
組織特異性：

Retina and brain. Somatodendritic compartment of neurons. Calbrain was found exclusively in brain where it is abundant in the hippocampus, habenular area in the epithalamus and in the cerebellum.
數(shù)據(jù)庫(kù)鏈接：

HGNC: 1384

OMIM: 605563

KEGG: hsa:9478

STRING: 9606.ENSP00000317310

UniGene: Hs.458482

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