BST1 Antibody
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中文名稱：BST1兔多克隆抗體
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貨號：CSB-PA052030
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規格：￥2024
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圖片：
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Western blot analysis of extracts from Jurkat cells and COS cells, using BST1 antibody.
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) BST1 Polyclonal antibody
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Uniprot No.：
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基因名：
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宿主：Rabbit
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反應種屬：Human,Mouse,Rat
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免疫原：Synthesized peptide derived from internal of Human BST1.
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免疫原種屬：Homo sapiens (Human)
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克隆類型：Polyclonal
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純化方式：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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濃度：It differs from different batches. Please contact us to confirm it.
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產品提供形式：Liquid
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應用范圍：ELISA,WB
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推薦稀釋比：
Application Recommended Dilution WB 1:500-1:3000 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
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靶點詳情
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功能：Synthesizes the second messengers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate, the former a second messenger that elicits calcium release from intracellular stores. May be involved in pre-B-cell growth.
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基因功能參考文獻：
- SNPs rs28532698 and rs4301112 in CD157 are not significantly associated with childhood autism spectrum disorder or the severity of the disease in a Chinese Han population. PMID: 29216786
- the rs4698412 variant of BST-1 may increase the Parkinson disease susceptibility. [META-ANALYSIS] PMID: 25986899
- Novel SCRG1/BST1 axis regulates self-renewal, migration, and osteogenic differentiation potential in mesenchymal stem cells. PMID: 24413464
- A pre-steady state and steady state kinetic analysis of the N-ribosyl hydrolase activity of hCD157. PMID: 25250980
- Studies indicate that vertebrate ADP-ribosyl cyclases (ARCs) Bst1 and CD38 with common gene structure of invertebrate ARC, suggesting the origin to the ancestor of bilaterian animals. PMID: 24896331
- Autism and with features of regression-previously acquired speech lost in the second year of life. The younger sister, who also had asthma, inherited a maternal deletion of 4p15.32 that results in a BST1-CD38 fusion transcript. PMID: 24634087
- BST1 rs11724635 polymorphism can interact with well water drinking to increase the risk of Parkinson's disease in a Taiwanese population. PMID: 24342025
- These findings indicate a central role of CD157 in cell-extracellular matrix interactions and make CD157 an attractive therapeutic target in inflammation and cancer. PMID: 24753259
- These results demonstrate for the first time that CD157 plays a role as a neuro-regulator and suggest a potential role in pre-motor symptoms in Parkinson's disease. PMID: 24795584
- A ligand-receptor complex SCRG1/BST1 axis facilitate mesenchymal stem cells migration, preserve OCT4 and CD271 expression, self-renewal and osteogenic differentiation. PMID: 24413464
- The results of this study indicated that the SNCA and BST1 SNPs generally increase the risk of developing PD and that SNCA rs11931074 in particular is associated with a higher risk of parkinson disease with family history. PMID: 23853107
- The results of this study showed that no causative mutation in the BST1 gene in patients with Parkinson's disease. PMID: 23827523
- This study confirmed the associations of BST1 with parkinson disease susceptibility and fail to show significant associations of alzheimer disease genome-wide association study (GWAS) top hits with PD susceptibility in a Korean population. PMID: 23820587
- BST1 SNPs rs11931532, rs12645693, & rs11724635 did not correlate with sporadic PD. The relationship of rs11724635 & sporadic PD had borderline significance. Smoking or caffeine intake did not correlate with SNP rs11724635 affecting sporadic PD. PMID: 23026536
- Findings implicate CD157 in the progression of EOC to metastatic disease and suggest that CD157 may represent a valuable therapeutic target. PMID: 22916288
- The SNPs investigated in the BST1, PARK15 and PARK9 genes associated with PD susceptibility are not associated with PD in the northern Han Chinese population. PMID: 22490479
- Direct replication of single nucleotide polymorphisms (SNPs) within SNCA and BST1 confirmed these two genes to be associated with the Parkinson's Disease in the Netherlands. PMID: 21248740
- The CD157-integrin partnership provides optimal adhesion and transmigration of human monocytes. PMID: 21478153
- found converging evidence of association with Parkinson's disease on 12q24 (rs4964469, combined P = 2.4 x 10(-7)) and confirmed the association on 4p15/BST1 (rs4698412, combined P = 1.8 x 10(-6)), previously reported in Japanese data PMID: 21084426
- PARK16, PARK8, and PARK1 loci but not BST1 are found to be associated with Parkinson's disease. PMID: 20697102
- CD157 plays a pivotal role in the control of ovarian cancer cell migration and peritoneal invasion, and it may be clinically useful as a prognostic tool and therapeutic target. PMID: 20639476
- crystal structures of the extracellular region of human BST-1 at atomic resolution in the free form and in complexes with five substrate analogues: nicotinamide, NMN, ATPgammaS, ethenoNADP, and ethenoNAD PMID: 11866528
- CD157 molecule displays two distinct domains in its extracellular component. The first is implicated in the enzymic activities of the molecule and the second features adhesion/signalling properties [review] PMID: 12415565
- Deficient in paroxysmal nocturnal hemoglobinemia; crucial to regulation of innate immunity during inflammation. PMID: 15328157
- The results confirm that CD157 physically interacts with CD11b/CD18 complex in human neutrophils PMID: 18211745
- Results show that CD38 and CD157 are expressed constitutively by corneal cells: CD38 appears as a 45-kDa monomer, while CD157 is a 42- to 45-kDa doublet. PMID: 19052657
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亞細胞定位：Cell membrane; Lipid-anchor, GPI-anchor.
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蛋白家族：ADP-ribosyl cyclase family
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組織特異性：Widely expressed.
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數據庫鏈接：
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