BRSK1 Antibody
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中文名稱：BRSK1兔多克隆抗體
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貨號：CSB-PA990856
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規格：￥2024
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圖片：
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Western blot analysis of extracts from 293 cells, using BRSK1 antibody.
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) BRSK1 Polyclonal antibody
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Uniprot No.：
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基因名：BRSK1
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宿主：Rabbit
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反應種屬：Human,Mouse
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免疫原：Synthesized peptide derived from internal of Human BRSK1.
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免疫原種屬：Homo sapiens (Human)
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克隆類型：Polyclonal
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純化方式：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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濃度：It differs from different batches. Please contact us to confirm it.
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產品提供形式：Liquid
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應用范圍：ELISA,WB
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推薦稀釋比：
Application Recommended Dilution WB 1:500-1:3000 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Serine/threonine-protein kinase that plays a key role in polarization of neurons and centrosome duplication. Phosphorylates CDC25B, CDC25C, MAPT/TAU, RIMS1, TUBG1, TUBG2 and WEE1. Following phosphorylation and activation by STK11/LKB1, acts as a key regulator of polarization of cortical neurons, probably by mediating phosphorylation of microtubule-associated proteins such as MAPT/TAU at 'Thr-529' and 'Ser-579'. Also regulates neuron polarization by mediating phosphorylation of WEE1 at 'Ser-642' in postmitotic neurons, leading to down-regulate WEE1 activity in polarized neurons. In neurons, localizes to synaptic vesicles and plays a role in neurotransmitter release, possibly by phosphorylating RIMS1. Also acts as a positive regulator of centrosome duplication by mediating phosphorylation of gamma-tubulin (TUBG1 and TUBG2) at 'Ser-131', leading to translocation of gamma-tubulin and its associated proteins to the centrosome. Involved in the UV-induced DNA damage checkpoint response, probably by inhibiting CDK1 activity through phosphorylation and activation of WEE1, and inhibition of CDC25B and CDC25C.
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基因功能參考文獻：
- These results suggest that frameshift mutations of EGR1 and BRSK1 might play a role in tumorigenesis through tumor suppressor gene inactivation in colorectal cancer and gastric cancer. PMID: 27677186
- BRSK1 is a novel tumor suppressor in breast cancer which inversely correlated with Jab1 expression. PMID: 25036402
- Single nucleotide polymorphism in BRSK1 is associated with the length of reproductive lifespan. PMID: 22131368
- acts as checkpoint kinase upon DNA damage induced by UV PMID: 15150265
- protein phosphatase 2C is a likely candidate for catalyzing the dephosphorylation and inactivation of BRSK1/2. PMID: 18339622
- STRADalpha.MO25alpha complexes containing LKB1 variants were equally effective at phosphorylating and activating AMPK, BRSK1, and BRSK2 PMID: 18854318
- SADB kinase activity controls centrosome homeostasis by regulating phosphorylation of gamma-tubulin. PMID: 19648910
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亞細胞定位：Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cell junction, synapse. Cell junction, synapse, presynaptic active zone. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle.
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蛋白家族：Protein kinase superfamily, CAMK Ser/Thr protein kinase family, SNF1 subfamily
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組織特異性：Widely expressed, with highest levels in brain and testis. Protein levels remain constant throughout the cell cycle.
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數據庫鏈接：
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