BMPER Antibody

中文名稱：

BMPER兔多克隆抗體
貨號：

CSB-PA839829LA01HU
規格：

￥440
圖片：
IHC image of CSB-PA839829LA01HU diluted at 1:200 and staining in paraffin-embedded human pancreatic cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
其他：

產品詳情
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靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) BMPER Polyclonal antibody
Uniprot No.：

Q8N8U9
基因名：

BMPER
別名：

BMP binding endothelial regulator antibody; BMP binding endothelial regulator precursor protein antibody; BMP-binding endothelial regulator protein antibody; BMPER antibody; BMPER_HUMAN antibody; Bone morphogenetic protein binding endothelial cell precursor derived regulator antibody; Bone morphogenetic protein-binding endothelial cell precursor-derived regulator antibody; CRIM3 antibody; Crossveinless 2 antibody; CV 2 antibody; CV2 antibody; hCV2 antibody; Protein crossveinless 2 antibody; Protein crossveinless-2 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human BMP-binding endothelial regulator protein (271-418AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，BMPER Antibody (CSB-PA839829LA01HU)，的標記方式是Non-conjugated。對于BMPER Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA839829LB01HU	BMPER Antibody, HRP conjugated	ELISA
FITC	CSB-PA839829LC01HU	BMPER Antibody, FITC conjugated
Biotin	CSB-PA839829LD01HU	BMPER Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, IHC

推薦稀釋比：

Application	Recommended Dilution
IHC	1:200-1:500

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Inhibitor of bone morphogenetic protein (BMP) function, it may regulate BMP responsiveness of osteoblasts and chondrocytes.
基因功能參考文獻：
1. Overexpression of BMPER remarkably enhanced BMP-2-induced osteogenic differentiation, while suppression of BMPER effectively inhibited this process both in vitro and in vivo. PMID: 29518774
2. that BMPER-modulated BMP pathway activity regulates VE-cadherin expression and vascular barrier function PMID: 27995357
3. BMPER variants associated with a novel, attenuated subtype of diaphanospondylodysostosis. PMID: 26467725
4. BMPER-dependent pathway involved in high glucose induced alkaline phosphatase expression in vascular smooth muscle cells. PMID: 26264461
5. The proangiogenic BMPER effect in endothelial cells is mediated by inhibition of antiangiogenic thrombospondin-1 and enhanced expression and activation of the FGF signaling pathway that is crucial in the promotion of angiogenesis. PMID: 25503991
6. BMPER is a novel regulator of the osteoblast-like differentiation of HCASMCs. PMID: 22778264
7. Bmper is a critical regulator of Bmp-mediated vascular inflammation and that the fine-tuning of Bmp and Bmper levels is essential in the maintenance of normal vascular homeostasis. PMID: 22772758
8. The data unequivocally demonstrated that BMPER is highly expressed in malignant tumors and that the growth of lung, colon, and uterine carcinomas is dependent on the presence of BMPER. PMID: 22020334
9. Mutual regulation by BMP-9 and CV2 is essential in regulating the development of the vascular endothelium. PMID: 22474252
10. Diaphonospondylodysostosis is caused by loss of BMPER function. PMID: 21990102
11. BMPER-mediated signaling plays an essential role in vertebral segmentation early in human development, while defects in BMPER produce Diaphanospondylodysostosis. PMID: 20869035
12. BMPER is a novel BMP-binding protein that is expressed by endothelial cell precursors, has BMP-antagonizing activity, and may play a role in endothelial cell differentiation by modulating local BMP activity PMID: 12897139
13. Crossveinless-2 is an inhibitor of BMP function PMID: 14766204
14. BMPER is an endothelial cell regulator and controls bone morphogenetic protein-4-dependent angiogenesis. PMID: 18787191
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相關疾病：

Diaphanospondylodysostosis (DSD)
亞細胞定位：

Secreted.
組織特異性：

Highly expressed in lung, and brain and also in primary chondrocytes.
數據庫鏈接：

HGNC: 24154

OMIM: 608022

KEGG: hsa:168667

STRING: 9606.ENSP00000297161

UniGene: Hs.660998

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