BHMT Antibody
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中文名稱：BHMT兔多克隆抗體
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貨號：CSB-PA002693GA01HU
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規格：￥3,900
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其他：
產品詳情
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Uniprot No.：
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基因名：BHMT
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別名：Betaine homocysteine methyltransferase antibody; Betaine homocysteine S methyltransferase 1 antibody; Betaine homocysteine S methyltransferase antibody; Betaine--homocysteine S-methyltransferase 1 antibody; BHMT antibody; BHMT1 antibody; BHMT1_HUMAN antibody; EC 2.1.1.5 antibody; Epididymis secretory sperm binding protein Li 61p antibody; HEL S 61p antibody
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宿主：Rabbit
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反應種屬：Human,Mouse,Rat
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免疫原：Human BHMT
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免疫原種屬：Homo sapiens (Human)
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抗體亞型：IgG
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純化方式：Antigen Affinity purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
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產品提供形式：Liquid
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應用范圍：ELISA,WB,IHC
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Involved in the regulation of homocysteine metabolism. Converts betaine and homocysteine to dimethylglycine and methionine, respectively. This reaction is also required for the irreversible oxidation of choline.
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基因功能參考文獻：
- Our study suggested markers in BHMT/BHMT2 and DMGDH might affect the risk of NSCL/P through pairwise interaction. PMID: 29356306
- BHMT (rs3733890) polymorphism showed no association with ALL. Hence this investigation needs further evaluation in larger sample size and effect of other SNPs, CNVs and miRNA's is required to elucidate the role of BHMT gene in ALL development. PMID: 28582843
- In genotypic combination analysis considering PEMT -744GG/CHDH +432GG/BHMT +742GG as the reference combination, PEMT -744GC/CHDH +432GG/BHMT +742GG genotypic combination was significantly higher in mothers of a down syndrome child compared with that in control mothers with an odds ratio of 2.061 (95% CI: 1.10-3.86, P=0.0342). PMID: 27677362
- It was concluded that during pregnancy, the BHMT pathway is affected by folate status and by the variant BHMT c.716A allele. PMID: 27735840
- low BHMT expression is correlated with aggressive malignant phenotype of HCC. Our data indicate that BHMT may serve as a novel prognostic marker for HCC. PMID: 26592251
- The faster evolutionary rate of BHMT2 overall suggests that selective constraints were reduced relative to BHMT. PMID: 26213999
- Multiple SNPs in BHMT and BHMT2 were identified to be associated with the occurrence of infant obstructive heart defects and interaction effects with maternal use of folic acid supplements. PMID: 25846410
- Data suggest BHMT is activated by binding of potassium ions; role of potassium ions in BHMT appears to be structural; potassium ions facilitate specific binding of substrate homocysteine (rather than substrate betaine) to active site of the enzyme. PMID: 24895213
- Study suggests BHMT holds considerable potential as a blood biomarker for acute liver injury. PMID: 25144858
- Women harboring the single nucleotide polymorphism BHMT 742G>A have a decreased risk of a Down Syndrome pregnancy. PMID: 23645037
- Known common single-nucleotide polymorphisms in MTRR and BHMT genes may not be significant risk factors for cororonary artery disease. PMID: 22339686
- Our study suggests that the polymorphism BHMT G742A may modulate the Down syndrome risk in Brazilian mothers. PMID: 22339736
- The BHMT 742GA or AA genotypes associated with tobacco consumption (P = 0.016) increase the risk for head and neck squamous cell carcinoma. PMID: 21630102
- A transcription variant of exon 4 of betaine-homocysteine methyltransferase (BHMT) produces a loss of function of BHMT in human hepatocarcinoma PMID: 22138536
- Three SNPs (rs41272270, rs16876512, and rs6875201), located 28kb upstream, in the 5'-UTR and in intron 1 of BHMT, respectively, were significantly correlated with both BHMT activity and protein levels. PMID: 21093336
- No significant level of association was found with cleft lip with or without cleft palate and BHMT variants. PMID: 21564312
- Results might suggest the protective role of the BHMT 239Gln variant in cervical cancer incidence. PMID: 21349258
- This suggests that polymorphism rs3797546 in the BHMT gene may confer genetic risk of NSCL/P in a recessive manner. PMID: 21565678
- gene-gene interaction analysis revealed significant epistatic interaction of BHMT2 (rs673752), PEMT (rs12325817), and PCYT1A (rs712012) with maternal NCL/P susceptibility. PMID: 20662904
- Observational study of gene-disease association, gene-gene interaction, gene-environment interaction, and genetic testing. (HuGE Navigator) PMID: 19948975
- mutagenesis of the zinc-binding motif reveals that Gly 214 is essential PMID: 11883905
- BHMT is a tetramer and its ability to methylate homocysteine is not affected by S-Adenosylmethionine (SAMe) PMID: 12071701
- X-ray structures of human BHMT in its oxidized (Zn-free) and reduced (Zn-replete) forms, the latter in complex with the bisubstrate analog, S(delta-carboxybutyl)-L-homocysteine, were determined at resolutions of 2.15 A and 2.05 A PMID: 12220488
- Study using intrinsic tryptophan fluorescence properties of BHMT demonstrates clearly that BHMT catalysis follows an ordered bi-bi mechanism and that betaine binding affinity is dependent on formation of the BHMT-homocysteine complex. PMID: 15122900
- S-adenosylmethionine and methylthioadenosine downregulaate BHMT expression in HepG2 cells. PMID: 16953798
- association between the homozygous mutant form of BHMT (742G-->A) polymorphism and increased risk for placental abruption. PMID: 17376725
- The BHMT/betaine system directly protects hepatocytes from homocysteine-induced injury but not tunicamycin-induced injury, including an endoplasmic reticulum stress response, lipid accumulation, and cell death. PMID: 17705221
- Experiments using the glutamate-cysteine ligase modifier subunit knockout mice Gclm(-/-), which are severely impaired in glutathione synthesis, show that BHMT activity is reduced about 75% in Gclm(-/-) compared to Gclm(+/+) mice. PMID: 18262489
- Common genetic variation in BHMT and BHMT2 and functionally characterized BHMT SNPs. PMID: 18457970
- betaine-homocysteine methyltransferase (BHMT) transgenic mice are resistant to alcohol or high methionine low folate diet -induced hyperhomocysteinemia and liver steatosis PMID: 18498552
- The BHMT 742 A allele was associated with resuced all-cause mortality. PMID: 18708404
- betaine-homocysteine methyltransferase gene (BHMT) rs3733890 polymorphism was associated with reduced breast cancer-specific mortality (hazard ratio, 0.64; 95% confidence interval, 0.42-0.97) PMID: 19635752
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亞細胞定位：Cytoplasm.
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組織特異性：Found exclusively in liver and kidney.
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數據庫鏈接：
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