Actb Antibody, Biotin conjugated
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中文名稱：Actb兔多克隆抗體, Biotin偶聯
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貨號：CSB-PA07675D0Rb
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規格：￥880
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其他：
產品詳情
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產品名稱：Rabbit anti-Mus musculus (Mouse) Actb Polyclonal antibody
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Uniprot No.：
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基因名：
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別名：ActbActin antibody; cytoplasmic 1 antibody; Beta-actin) [Cleaved into: Actin antibody; cytoplasmic 1 antibody; N-terminally processed] antibody
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宿主：Rabbit
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反應種屬：Mouse
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免疫原：Recombinant Mouse Actin, cytoplasmic 1 protein (11-375AA)
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免疫原種屬：Mus musculus (Mouse)
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標記方式：Biotin
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：>95%, Protein G purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 -
產品提供形式：Liquid
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應用范圍：ELISA
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.
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基因功能參考文獻：
- Data, including data from studies using knockout mice, suggest that Actb and Actg1 are enriched in isolated membrane preparations from skeletal muscle which represent interface between mitochondria and sarco-endoplasmic reticulum; these structures appear to be important in signaling, mitochondrial dynamics, and muscle relaxation. (Actb = beta actin cytoplasmic 1; Actg1 = actin gamma cytoplasmic 1) PMID: 29265728
- Essential nucleotide- and protein-dependent functions of Actb/beta-actin. PMID: 30012594
- These results suggest a a novel genome-wide mechanism where the polymerase-associated beta-actin synergizes with NM1 to coordinate permissive chromatin with Pol I transcription, cell growth, and proliferation. PMID: 27127100
- Two actin isoforms, beta- and gamma-actin, are crucial for slow, rapid, bulk, and overshoot endocytosis at large calyx-type synapses, and for slow endocytosis and bulk endocytosis at small hippocampal synapses. PMID: 27840001
- Melatonin treatment for 1 h increased monomeric actin and decreased polymeric actin. PMID: 28209510
- Disruption of the in vivo interaction of KIF11 with ZBP1 delocalizes beta-actin mRNA and affects cell migration. PMID: 25588836
- TIA proteins can function as long-term regulators of the ACTB mRNA metabolism in mouse and human cells. PMID: 24766723
- Actin binding proteins associated with stress fiber or focal adhesion formation are overexpressed in the beta-actin knock-out cells and many of these contain CH-, LIM- or EFh- domains. PMID: 24123846
- Absence of beta-actin severely hampers formation of the peripheral nervous system, due to defective neural crest migration. PMID: 24409333
- Data indicate that ectopic phosphatidylinositol 3,4,5-triphosphate (PIP3) elevation alone activated membranes to form actin-based structures whose behavior was similar to that of growth-cone-like "waves". PMID: 23951027
- this work demonstrated that dendritic beta-actin messenger RNA and ribosomes are in a masked, neuron-specific form. PMID: 24458642
- chorein interacts with beta-adducin and beta-actin. PMID: 24129186
- RNA polymerase II, glyceraldehyde-3-phosphate dehydrogenase (Gapdh), and hypoxanthine phophoribosyltransferase (Hprt) show a more stable gene expression as candidate genes than do ribosomal 18s and Actb. PMID: 22735032
- The findings suggested that local translation of beta-actin in growth cones of motoneurons is regulated by laminin signalling and that this signalling is disturbed in survival of motoneuron protein-deficient motoneurons. PMID: 22810847
- Data suggest that in beta-actin knockout cells other actins compensate for beta-actin in cell migration process. PMID: 22448045
- Data indicate that Ubc and Ywhaz were best correlated for B cells and lymphocytes, whereas Ubc and Gapdh were the best combination for non-B cells, and Actb and Hprt1 were the least stably expressed genes for B cells and non-B cell. PMID: 22884776
- the zipcode-binding protein 1 transports beta-actin mRNA to the focal adhesion compartment, it dwells for minutes, associating its localization with motility through the formation of stable connections between adhesions and newly synthesized actin filaments PMID: 22948660
- These data show that thymosinbeta4 and beta-actin are over-expressed during nurse cell formation upon T. spiralis infection and may be involved in nurse cell formation along with other actin-binding proteins. PMID: 22305657
- novel roles for beta-actin in promoting complex CNS tissue architecture PMID: 22403730
- Beta- and gamma-cytoplasmic actins are required for meiosis in mouse oocytes. PMID: 21778137
- These data support an essential role for beta-actin in regulating cell migration and gene expression through control of the cellular G-actin pool PMID: 21900491
- Perturbing the dystrophin and beta actin interaction results in quadriceps myopathy. PMID: 21325027
- Nuclear beta-actin controls growth arrest of epithelial cells. PMID: 21172822
- Results demonstrate overlapping developmental roles but unique post-developmental functions for beta-actin and gamma-actin in maintaining hair cell stereocilia. PMID: 20976199
- Data show that exposure to hyperoxia resulted in significant increases in eNOS-beta-actin association, eNOS activity, and protein tyrosine nitration in the lungs. PMID: 20826796
- arginylated gamma-actin, unlike beta-, was highly unstable and selectively ubiquitinated and degraded in vivo; instability was regulated by differences in nucleotide coding sequence between the actin isoforms, which conferred different translation rates PMID: 20847274
- HnRNP-R-mediated axonal beta-actin mRNA translocation plays an essential physiological role for axon growth and presynaptic differentiation. PMID: 20167579
- Dystrophin and utrophin bind actin through distinct modes of contact PMID: 16478721
- beta-actin was arginylated in vivo to regulate actin filament properties, beta-actin localization, and lamella formation in motile cells PMID: 16794040
- Data show that beta-actin characteristic markers of brush borders, become abnormally distributed along these atypical basolateral membranes in gal3(-/-) mice. PMID: 18211959
- The cytoplasmic beta-actin (Actb) gene generates two alternative transcripts terminated at tandem polyA sites. PMID: 18835850
- Ischemia-mediated aggregation of the actin cytoskeleton is one of the major initial events resulting in ischemia-reperfusion injury. PMID: 19095765
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亞細胞定位：Cytoplasm, cytoskeleton. Nucleus.
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蛋白家族：Actin family
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組織特異性：Expressed in the epididymis (at protein level). Expressed in the kidney (at protein level).
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數據庫鏈接：
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