ARPC4 Antibody

中文名稱：

ARPC4兔多克隆抗體
貨號(hào)：

CSB-PA002130LA01HU
規(guī)格：

￥440
圖片：
IHC image of CSB-PA002130LA01HU diluted at 1:300 and staining in paraffin-embedded human lung tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

Immunofluorescence staining of Hela cells with CSB-PA002130LA01HU at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
其他：

產(chǎn)品詳情
產(chǎn)品評(píng)價(jià)
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靶點(diǎn)詳情

產(chǎn)品詳情

產(chǎn)品名稱：

Rabbit anti-Homo sapiens (Human) ARPC4 Polyclonal antibody
Uniprot No.：

P59998
基因名：

ARPC4
別名：

Actin related protein 2/3 complex subunit 4 antibody; Actin related protein 2/3 complex subunit 4 20 kD antibody; Actin related protein 2/3 complex subunit 4 20kDa antibody; Actin related protein 2/3 complex; 20-KD subunit antibody; Actin-related protein 2/3 complex subunit 4 antibody; ARC20 antibody; Arp2/3 complex 20 kDa subunit antibody; Arp2/3 protein complex subunit p20 antibody; ARPC 4 antibody; ARPC4 antibody; ARPC4_HUMAN antibody; MGC13544 antibody; OTTHUMP00000165252 antibody; OTTHUMP00000207520 antibody; p20 Arc antibody; p20-ARC antibody; p20ARC antibody
宿主：

Rabbit
反應(yīng)種屬：

Human
免疫原：

Recombinant Human Actin-related protein 2/3 complex subunit 4 protein (2-168AA)
免疫原種屬：

Homo sapiens (Human)

標(biāo)記方式：

Non-conjugated

本頁面中的產(chǎn)品，ARPC4 Antibody (CSB-PA002130LA01HU)，的標(biāo)記方式是Non-conjugated。對(duì)于ARPC4 Antibody，我們還提供其他標(biāo)記。見下表：

標(biāo)記方式	貨號(hào)	產(chǎn)品名稱	應(yīng)用
HRP	CSB-PA002130LB01HU	ARPC4 Antibody, HRP conjugated	ELISA
FITC	CSB-PA002130LC01HU	ARPC4 Antibody, FITC conjugated
Biotin	CSB-PA002130LD01HU	ARPC4 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

ELISA, IHC, IF

推薦稀釋比：

Application	Recommended Dilution
IHC	1:200-1:500
IF	1:50-1:200

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
儲(chǔ)存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

功能：

Actin-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA. The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs).
基因功能參考文獻(xiàn)：
1. Expression of the ARPC4 severely affects mycobacterium tuberculosis growth and suppresses immunogenic response in murine macrophages PMID: 23894563
2. we show cell line-specific differences in ARP2/3 complex subunit dependency on cell migratory potential, and suggest ARPC4 to be one of the key members of the ARP2/3 complex in pancreatic cancer. PMID: 23267127
3. We show that coronin 3 similar to other coronins interacts with the Arp2/3-complex and cofilin indicating that this family in general is involved in regulating Arp2/3-mediated events. PMID: 17274980
亞細(xì)胞定位：

Cytoplasm, cytoskeleton. Cell projection. Nucleus.
蛋白家族：

ARPC4 family
數(shù)據(jù)庫鏈接：

HGNC: 707

OMIM: 604226

KEGG: hsa:10093

STRING: 9606.ENSP00000388169

UniGene: Hs.323342

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